PLoS ONE
Articles in this Issue
The effects of adolescent social isolation and group housing on adolescent binge drinking in mice
Adolescence is a developmental period characterized by behavioral changes such as sensation seeking, impulsivity, and diminished self-control to inhibit behaviors, which can lead to increased risky be...
Herpes simplex virus detection and genomes from under-sampled, remote populations
Herpes simplex virus (HSV) is an endemic pathogen, infecting over half of all adults world-wide. HSV infection can cause a wide spectrum of disease outcomes, ranging from asymptomatic infection or mil...
Orientation of Gp96 and Calreticulin T-cell epitopes in a multiepitope HPV16 E7 vaccine construct affects predicted immunostimulatory properties: An in silico and expression validation study
Heat shock proteins (HSPs) can be used as adjuvants to develop therapeutic vaccines, as they enhance the cross-presentation of related tumor antigens and stimulate T cells. In this study, the immunost...
Long noncoding RNA Gpr137b-ps mediates 15-PGDH-induced angiogenesis in brain microvasculature following tMCAO in mice
Background Angiogenesis is essential for recovery following ischemic stroke, as brain microvascular endothelial cells (BMVECs) drive vascular repair. 15-hydroxyprostaglandin dehydr...
Comparison of AID users and non-users regarding glycemic control and diabetes distress: A mixed-methods study
Aim This study compared glycemic control and diabetes distress in individuals with type 1 diabetes using automated insulin delivery (AID) systems versus those not using such system...
Outcome of distal femoral replacement: Influence of trauma vs. elective indications – A prospective single-center study
Background Distal femoral replacement (DFR) is often the last leg-saving option in advanced femoral bone defects after total knee arthroplasty (TKA) and periprosthetic distal femor...
Numerical simulation study on the energy dissipation characteristics of energy-dissipating pile-anchor structures
This study investigates the energy dissipation mechanisms and damage evolution of energy-dissipating and ductile pile-anchor structures under seismic loading through numerical simulation. A three-dime...
Decision tree model to assess consequences and costs associated with therapy administration pathways for patients with HER2+ breast cancer in Italian oncological centers
Background and aims Human Epidermal Growth Factor Receptor 2-positive (HER2+) breast cancer poses significant therapeutic challenges, particularly concerning treatment administrati...
EPAS1 knockdown is associated with cell cycle and DNA replication programs and MYC/E2F-related signatures in hemangioma endothelial cells
Infantile hemangioma (IH) is the most common benign tumor of infancy. Hypoxia and activation of hypoxia-inducible factor (HIF) signaling have been proposed to contribute to IH pathogenesis, yet the ro...
Multi-view graph-regularized deep metric subspace clustering network
Multi-view subspace clustering has progressed significantly by using deep neural networks to handle nonlinear data representations. A recent advancement, the Multi-view Self-Expressive Subspace Cluste...
Dynamic proprioceptive training improves functional recovery in sprinters with patellofemoral pain: A randomized trial
Background Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition among physically active individuals, particularly sprinters, and is frequently associated with...
Associations between health-related social capital and oral frailty risk among older adults: A stratified analysis by socioeconomic status in the JAGES longitudinal study
Background Although socioeconomic inequalities in oral health persist despite universal dental care, the role of social determinants remains unclear. Social capital may influence o...
Kilowatt-class planar four-way gysel combiner with power-aware impedance optimization for L-band pulsed radar
This work presents a compact planar four-way Gysel power divider/combiner designed for kilowatt-class coherent power combining in L-band pulsed radar transmitte...
Analysis of swimming teaching programs, aquatic competencies and specific skills in school settings from early childhood to secondary education: A systematic review
The teaching of swimming in school contexts has become increasingly important due to the benefits in the integral development of students and the prevention of aquatic accidents.This study analyses, b...
Virtual screening of Kocuria oceani AT-1 metabolites as potential maize growth regulators under drought conditions using molecular docking and dynamics simulation
Maize is a vital cereal crop, severely affected by environmental factors and climate change. Among abiotic factors, drought stress is considered one of the most detrimental factors limiting plant grow...
Knowledge and awareness of oral cancer among adults in North-Western Italy: A cross-sectional questionnaire-based survey in community pharmacies
Early detection is a key determinant of prognosis in oral squamous cell carcinoma (OSCC); however, delayed diagnosis remains common. Insufficient public awareness and knowledge of OSCC have been ident...
Evaluating the feasibility and effectiveness of a capacity-building model to nurture junior independent clinical research investigators in Uganda
Background Research capacity-building initiatives remain crucial to achieving Sustainable Development Goal 3 on health and well-being, especially in LMICs. We aimed to evaluate the...
Numerical simulation study on pressure response and fluid loss mechanism of coal fracture network under particle temporary plugging
To address the issue of fluid loss leading to pressure failure when applying temporary plugging fracturing technology from the oil industry to enhance gas recovery in coal mines, and considering the c...
Effects of different oral intake management during labor on maternal and neonatal outcomes: A protocol for a systematic review and network meta-analysis
Introduction Fasting or restricting oral intake during labor may adversely affect maternal and neonatal outcomes. Although several interventions regarding oral intake during labor...
A multi-agent equilibrium model in an incomplete market with discrete dividends: Applications to long-term discount curves
This paper develops a multi-agent equilibrium model in an incomplete market setting. The model incorporates dividend-paying securities whose dividend processes are interpreted as flows of consumption...
Hidden deficiency under bright skies: Vitamin D prevalence and genetic associations in African Type 2 diabetes: A systematic review and meta-analysis
Background Type 2 diabetes mellitus (T2DM) has become a significant health challenge in Africa, with rapidly increasing prevalence. Despite abundant sunlight, vitamin D deficiency...
Correction: Longitudinal changes in circulating biomarkers from baseline to week 48 in treatment-Naïve people living with HIV initiating integrase inhibitor-based antiretroviral therapy
Randomized single-blind study to examine the implementation and effectiveness of integrating evidence-based early relational health programs in pediatrics for families with low incomes: A clinical trial protocol
Disparities in early childhood development due to poverty are linked to lifelong gaps in health and well-being. To address such disparities, interventions must not only include the prevention of toxic...
Tissue-specific amino acid accumulation in Cynomorium songaricum stem and epidermis responds to distinct water and soil cues
This study provides the first evidence, from the perspective of intra-organ metabolic division of labour, that Cynomorium songaricum adapts to the heterogeneity...
Diagnostic accuracy of circulating microRNAs and lipidomic biomarkers for early breast cancer detection: A systematic review and meta-analysis
Background Breast cancer outcomes improve substantially with earlier detection, yet mammography performance can be limited in dense breasts and may lead to false-positive investiga...