PLoS ONE
Articles in this Issue
Research on Benggang identification and deformation monitoring based on optical and Radar data
Benggang erosion, a severe soil erosion landform in southern China, threatens ecological security and regional development. Conventional methods can delineate surface morphology but lack capability to...
Incidence of tuberculosis in patients with immune-mediated diseases undergone biological therapy: A 10-year observational study in a high-burden region of northeastern Brazil
Biological therapies are critical in the management of Immune-Mediated Diseases (IMDs), yet their use is linked to adverse effects, including an elevated risk of Tuberculosis (TB), a significant healt...
Evaluating the cultural alignment of multilingual LLMs in typical Japanese workplace scenarios
While current evaluations of LLM cultural alignment predominantly rely on static benchmarks in Western contexts, their ability to navigate generative, high-context socio-pragmatic demands in non-Weste...
PAP_NER: A large-scale vietnamese administrative named entity recognition corpus and hybrid deep learning architecture
Named Entity Recognition (NER) is fundamental for automating administrative document processing in digital government systems. However, Vietnamese NLP research faces a critical infrastructure gap: exi...
Cyclodextrin inclusion complexes enhance the solubility and anti-virulence activity of metronidazole against uropathogenic Proteus mirabilis
Proteus mirabilis is a major uropathogen implicated in catheter-associated urinary tract infections and infection-induced urolithiasis, often exhibiting multidrug resistance. Improving the solubility...
Helminth-derived stefin-1 selectively reduces leukemic cell viability and promotes apoptosis in U937 cells
Leukemia remains a challenging hematological malignancy, particularly due to treatment resistance and the limited availability of therapies that selectively target cancer cells. Helminth-derived cyste...
Outcomes of proximal humeral chondroblastoma treated with intralesional curettage, electrocauterization of the cavity and bone grafting: A retrospective study
Objectives This study aimed to evaluate the 7-year outcomes of proximal humeral chondroblastoma treated with intralesional curettage, electrocauterization of the cavity and bone gr...
SPP1 promotes cisplatin resistance in cervical cancer by regulating KRAS expression
Background Chemotherapy resistance is a major treatment issue for cervical cancer (CC), contributing to high morbidity and mortality. This study identifies key molecular drivers of...
Socioeconomic disparities in children’s neurodevelopment before and during primary education: Evidence from Bagamoyo, Tanzania
Background Socioeconomic disparities in children’s neurodevelopment constitute a critical yet understudied developmental challenge in low- and middle-income countries (LMICs), yet...
Police emergency dispatch model based on emergency level analysis and traffic planning
Emergency dispatching and rescue during emergencies have become a hot research topic in the field of transportation planning. Therefore, to address the low efficiency of cross-regional police emergenc...
Phenotypic variations of naturally grown Iris persica L. accessions as revealed using multivariate analytical methods
Iris persica L. is a high-value ornamental species naturally distributed across montane regions of Iran, yet its intraspecific morphological variation remains underexplored. Unders...
Bacterial profile and antimicrobial resistance patterns of bloodstream infections at Amhara Public Health Institute, Bahir Dar, Ethiopia
Background Managing bloodstream infections in resource-constrained regions like Ethiopia is challenging due to scarce blood culture surveillance data. To guide empirical therapy, t...
Temporal trends in children pertussis burden in China and worldwide from 1990 to 2023: An analysis of the Global Burden of Disease Study 2023
Objective To evaluate the burden trends of children pertussis worldwide and in China from 1990 to 2023, and predict the disease burden for the next 10 years using a secondary analy...
Leveraging free-text clinical records for heart disease classification through structured feature mapping
Hypertension and diabetes are major risk factors for heart disease, which remains among the leading causes of morbidity and mortality worldwide. Heart disease includes heart failure, myocardial infarc...
Path planning for mobile robots by fusing ant colony optimization and dynamic window approach
To address the problems of low global optimization efficiency and insufficient safety in local obstacle avoidance when mobile robots perform path planning in dynamic and complex environments, this pap...
An evaluation of a breastfeeding peer support service in North East England: A qualitative study with service users, practitioners and volunteers
Background Breastfeeding has health benefits for women and infants. Although the WHO recommends that infants are breastfed exclusively for the first six months, exclusive breastfee...
The effectiveness of a knowledge graph-based lifestyle intervention recommendation system in improving body composition, muscle strength, and physical function in sarcopenic obesity: Study protocol for a randomized controlled trial
Background Sarcopenic obesity (SO) is a complex condition characterized by the coexistence of sarcopenia and obesity, with pathophysiological mechanisms extending beyond the additi...
Understanding the underuse: Barriers to vacuum-assisted birth among clinicians in Tanzania: An exploratory qualitative study
Background Vacuum-assisted birth (VAB) is a critical obstetric intervention for saving the lives of the mothers and newborns, particularly in cases of prolonged second-stage labor,...
Pilot study: The effect of eight weeks of aerobic training in the two phases of light and dark circadian rhythm on genes (OCT4, NANOG, SOX2, REX1) in bone tissue of diabetic mice
Introduction Diabetes mellitus impairs bone metabolism through chronic hyperglycemia, oxidative stress, and inflammation, leading to reduced osteoblast activity and downregulation...
Impact of semaglutide withdrawal on cardiometabolic profile and physiology of energy balance: Recovery effects after semaglutide termination – The REST trial study protocol
Background Glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide have been shown to induce substantial weight loss and improve cardiometabolic risk factors in patie...
Model-free predictive control for PMSM based on a nonlinear autoregressive exogenous model and an adaptive recursive least squares algorithm
This paper proposes a novel nonlinear autoregressive with exogenous input-based adaptive recursive least squares model-free predictive control (NARX-ARLS-MFPC) strategy for permanent magnet synchronou...
Experimental emergence of conventions in human dyads
Conventions can be defined as arbitrary and self-sustaining practices that emerge in a population and facilitate solving coordination problems. A recent study traced the formation of simple convention...
In vivo changes in zebrafish anesthetic sensitivity in response to the loss of kif5Aa are associated with the alteration of mitochondrial motility
Anesthetic and sedative drugs are small compounds known to bind to hundreds of proteins. One intriguing binding partner of propofol is the motor domain of a neuronal mitochondrial transport kinesin, k...
An approach of state-of-charge prediction for lithium-ion batteries using hybrid Pyraformer-LSTM learning network
Accurate prediction of the State of Charge (SOC) of lithium-ion batteries remains difficult under complex operating conditions. This difficulty arises from strong nonlinearity and long-term temporal d...
IL5 rs2069812 and IL13 rs1800925 Genetic variants as key determinants of clinically relevant asthma phenotypes
Type 2-high airway inflammation in adults with asthma is heavily driven by the cytokines interleukin (IL)-4, IL-5, and IL-13. While genetic variations in these cytokines are known to influence asthma...