PLoS ONE
Articles in this Issue
Efficacy and safety of ureterorenoscopy in the elderly: A systematic review axnd meta-analysis
Objective Ureterorenoscopy (URS) is a common procedure performed for renal or upper ureteric stones. Nevertheless, the efficacy and safety of URS in the elderly is unclear. We conducted the first meta...
Alterations in the inflammatory markers of the Tumor Necrosis Factor system in overweight and obese children and adolescents
Objective This study analyzed the association between cardiometabolic risk markers and the tumor necrosis factor system in overweight and obese children and adolescents. Methods This cross-sectional...
Colorectal cancer risk prediction using a simple multivariable model
Accurate population stratification of colorectal cancer risk enables identification of individuals who would benefit from screening and risk-reducing interventions. We conducted a population-based coh...
Higher social class is associated with higher contextualized emotion recognition accuracy across cultures
We tested links between social status and emotion recognition accuracy (ERA) with participants from a diverse array of cultures and a new model and method of ERA, the Assessment of Contextualized Emot...
Developing an innovation and enterprise framework for translating UK-driven global health research into commercially viable interventions: the FLIGHT study protocol
The UK Higher Education Institution (HEI) sector faces significant challenges in translating early-stage research into commercially viable public health products, particularly in infectious diseases....
The role of Kaizen in the effectiveness of Amhara metal industry and machine technology development enterprise in Ethiopia, as perceived by the employees
This study investigated the role of Kaizen in the effectiveness of the Amhara Metal Industry and Machine Technology Development Enterprise in Ethiopia, as perceived by its employees. To this end, the...
Therapeutic potential of anti-thymocyte globulin in type 1 diabetes: A systematic review
Background Type 1 diabetes (T1D) is an autoimmune condition characterized by the destruction of insulin-producing beta cells in the pancreas. Anti-Thymocyte Globulin (ATG) has emerged as a promising i...
Exploring the relationship between mental work load, work ability, and musculoskeletal disorders: A cross-sectional modeling study among health service workforces in Iran
Introduction The health service workforces play a crucial role in shaping a nation’s health system efficiency, making it vital to understand factors affecting their performance. This study examined th...
An adaptive coordination control solution to boost frequency stability for a hybrid distributed generation system
Under the current global circumstances, the urgent need to exploit renewable energy sources (RESs) is increasing. Increased penetration of RESs in hybrid distributed generation systems (HDGSs) poses a...
Therapeutic application of nano-encapsulated pomegranate peel extract attenuated DSS-induced colitis: Antioxidant and anti-inflammatory role and reduction of exaggerated response of endoplasmic reticulum stress
The medicinal application of pomegranate peel extract enriched with polyphenols (PPE) as a therapeutic strategy for managing inflammatory bowel diseases (IBD) is still limited. Integrating pomegranate...
Targeting tumor-associated genes, immune response, and circulating tumor cells in intrahepatic cholangiocarcinoma: Therapeutic potential of Atractylodes lancea (Thunb.) DC
Cholangiocarcinoma (CCA) is one of the most aggressive cancers with a poor prognosis. Current treatment strategies involve hepatobiliary surgery, chemotherapy, radiotherapy, and supportive care; howev...
dTOURS: Dense-region tagging for outbreak detection using ratio statistics
Surveillance for food safety in the United States of America is a collaborative effort among public health agencies with additional partners worldwide contributing sequence data. Assemblies in GenBank...
Oaxaca-Blinder meets Kitagawa: What is the link?
Recently, papers have started combining the naming of two popular decomposition methods: the Oaxaca-Blinder (OB) method and the Kitagawa method, a popular method in demographics and sociology. Althoug...
Discovery of ROCK2 inhibitors through computational screening of ZINC database: Integrating pharmacophore modeling, molecular docking, and MD simulations
Rho-associated protein kinase 2 (ROCK2) is a serine/threonine kinase that is crucial for regulating various physiological processes and is part of the Rho-associated coiled-coil kinase family. The dys...
Impact of technology- and parent-based psychosocial interventions on family dynamics factors in children with cancer: A systematic review
Objective This systematic review aimed to examine the impact of technology- and parent-based psychosocial interventions on family factors among children with cancer, focusing on family dynamics. Met...
Short-term real-world outcomes of diabetic macular edema treated with intravitreal faricimab
Faricimab, a new drug for diabetic macular edema (DME), was made available in Japan in 2022. However, few reports have been published about its treatment outcomes in clinical practice. To assess the s...
Tumour-associated macrophages in human meningiomas
Tumour-associated macrophages (TAMs) are regarded as potential therapeutic targets due to “pro-tumoral” and “anti-tumoral” phenotypes. Human meningiomas contain considerable number of TAMs, but their...
Effect of perioperative lidocaine infusion on the subjective quality of recovery after surgery: Protocol for an updated systematic review and meta-analysis
Background Lidocaine is increasingly used for surgical patients requiring general anesthesia. However, its clinical benefits on postoperative recovery quality are not well established. Our main object...
High NE dose trajectory is associated with new onset of acute kidney injury patients: A group-based trajectory modeling analysis
Background Norepinephrine (NE) is a first line and effective vasopressor for septic shock management, but its impact on newonset acute kidney injury (AKI) in those patients remains controversial. This...
A novel methodological approach to SaaS churn prediction using whale optimization algorithm
Customer churn is a critical concern in the Software as a Service (SaaS) sector, potentially impacting long-term growth within the cloud computing industry. The scarcity of research on customer churn...
Economic impact and disease burden of COVID-19 in a tertiary care hospital: A three-year analysis
Background The COVID-19 pandemic has increased morbidity and mortality, along with substantial economic repercussions for healthcare systems and communities worldwide. This study describes the costs i...
Assessment of consumer perspectives on the use of paper packaging in Trinidad
Background Paper packaging is increasingly being used to replace single use plastics to mitigate the negative effects of plastic pollution on the environment. While many developed countries have made...
Editorial Note: Extensive culturomics of 8 healthy samples enhances metagenomics efficiency
Malicious traffic prediction model for ResNet based on Maple-IDS dataset
In light of the increasing threat posed by cyberattacks, it is imperative for organizations to accurately identify malicious network traffic. However, the imbalance among various attack categories dim...
Research on low-Impact development layouts in old urban residential communities based on multi-objective optimization
Challenges such as poor drainage systems and limited space for renovation often arise during the sponge city transformation of old urban residential communities. This research focuses on an old reside...