PLoS ONE
Articles in this Issue
Nucleolar sequestration of cannabinoid type-2 receptors in triple-negative breast cancer cells
Multiple investigations have shown that the different types of cannabinoids, phytocannabinoids, synthetic cannabinoids, and endocannabinoids, possess antiproliferative and anticancer properties. The c...
Sufficient dimension reduction on partially nonlinear index models with applications to medical costs analysis
Modeling medical costs is a crucial task in health economics, especially when high-dimensional covariates and nonlinear effects are present. In this study, we propose a partially nonlinear index model...
What drives the effectiveness of social distancing in combating COVID-19 across U.S. states?
We propose a new theory of information-based voluntary social distancing in which people’s responses to disease prevalence depend on the credibility of reported cases and fatalities and vary locally....
Retraction: Urban transportation system toughness assessment under New Crown epidemics
Correction: Clusters from chronic conditions in the Danish adult population
Assessing potential collateral effects on amphibians from insecticide applications for flea control and plague mitigation
Ideal disease mitigation measures for wildlife are safe and benign for target species, non-target organisms, the environment, and humans. Identifying collateral (i.e., unintended) effects is a key con...
Rubus coreanus extract prevents kidney fibrosis through TGF-β/Smad pathway inhibition
Rubus coreanus has been found to have various health benefits including anti-oxidative effects. In this study, we aimed to investigate the efficacy of water-soluble extract of Rubus coreanus (MN705) i...
Heparinase I treatment to overcome RNA quantification interference in heparinized liver donor samples: One size fits all?
Background MicroRNAs have emerged as potential biomarkers of liver injury during organ transplantation due to their specificity, easy detection and stability in many biofluids. Heparin, which has a we...
Internationalization of family firms on innovation: Moderating impact of socioemotional wealth and institutional environment
Currently, there is a lack of research specifically investigating the influence of internationalization on the innovation of family firms. This paper aims to investigate the influence of both internat...
Insomnia symptoms among individuals with osteoarthritis and symptoms indicative of osteoarthritis: A population-based cross-sectional study using the CLSA
Objective To compare the prevalence and examine the likelihood of insomnia symptoms in middle- and older-aged adults with an osteoarthritis (OA) diagnosis and with joint symptoms indicative of OA but...
The protocol for a pilot feasibility trial of Improving Neurodevelopmental ouTcomes After prenatal Cannabinoid in uTero exposure (INTACT) study for a multi-center trial
Background Legalization of recreational cannabis use is expanding across the United States, and prenatal cannabis has steadily increased. Evidence suggests that many pregnant individuals use cannabis...
Automated self-service cohort selection for large-scale population sciences and observational research: The California Teachers Study researcher platform
Objective Cohort selection is ubiquitous and essential, but manual and ad hoc approaches are time-consuming, labor-intense, and difficult to scale. We sought to automate the task o...
Impact of prior SARS-CoV-2 infection on perioperative cardiac, pulmonary and neurocognitive complications in older patients: Study protocol for an observative case control study
Background Postoperative delirium is considered a serious complication in older patients. Older patients often suffer from several concomitant diseases. The reduced physical condition can increase the...
Retraction: Evaluating the effect of therapeutic stem cells on TRAIL resistant and sensitive medulloblastomas
Research analytics on the applications of flexible formwork gob-side entry retention technology in medium-thickness coal seams with large inclination angles
Gob-side entry retention (GER) has been successfully advanced and implemented for several years. Notably, strong economic returns have been realised for different thicknesses of coal seams under near-...
Ubiquitous expression of an activating mutation in the Pik3ca gene reprograms glucose and lipid metabolism in mice
Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most common mutations in human cancers and overgrowth syndromes. The ubiquitous expression of the activating P...
Effects of upper-limb aerobic exercise plus general exercise versus general exercise alone among patients with spinal cord injury in northern Nigeria: A protocol for a randomized controlled trial
Introduction Spinal cord injury (SCI) is a devastating injury often associated with immobility, leading to numerous complications, with cardiovascular disorders being among the major causes of mortali...
Study of the psychometric properties of the HLS-EU-12 questionnaire in rural Bangladesh
Objectives Poorer health literacy leads to limited knowledge of diseases and lower adherence to medication. Several tools are available for measuring health literacy, including the HLS-EU-Q12 question...
The lncRNA SENCR knockdown alleviates vascular calcification via miR-4731-5p by suppressing endoplasmic reticulum stress
Background Accumulation of calcium phosphate crystals is associated with vascular calcification (VC); however, the mechanism that promotes VC remains unclear. Accumulating evidence indicates that smoo...
A transgenic mouse line for rabies virus-mediated trans-synaptic tracing in the postnatal developing brain
Neural circuits are composed of numerous neurons that perform diverse functions. Understanding the mechanisms of neural processing requires elucidating the connections among individual neurons. Rabies...
Enhanced surveillance for tick-borne rickettsiosis and ehrlichiosis in North Carolina: Protocol and preliminary results
North Carolina (NC) experiences some of the highest incidence rates of spotted fever rickettsiosis (SFR) and ehrlichiosis in the United States (US). Due to the non-specific nature of clinical symptoms...
Research on the coupled dynamics and prediction of Macao’s tourism-economy-ecosystem from a policy perspective
A harmonious integration of urban tourism, economy, society, and environmental development is crucial for the sustainable development of urban tourism. This study takes the Macao Special Administrativ...
A research on spatial configuration characteristics and social performance evaluation of public sports facilities in shanghai based on geographic information system (GIS)
The spatial configuration and social performance of public sports facilities serve as crucial indicators for evaluating the equity of public sports services and the coherence of urban spatial structur...
Exploring dynamical whole-brain models in high-dimensional parameter spaces
Personalized modeling of the resting-state brain activity implies the usage of dynamical whole-brain models with high-dimensional model parameter spaces. However, the practical benefits and mathematic...
Cardiovascular safety of Janus kinase inhibitors: A pharmacovigilance study from 2012–2023
Janus kinase inhibitors (JAKinibs) are increasingly used for autoimmune diseases, prompting concerns about their cardiovascular safety. This study aims to assess the cardiovascular safety of JAKinibs...