PLoS ONE
Articles in this Issue
Targeted transarterial embolization of the femoral head: development of a minimally invasive approach to model Legg-Calvé-Perthes disease in piglets
Clinical management of children with Legg-Calvé-Perthes Disease (LCPD) is hampered by incomplete understanding of how the extent of ischemic injury and the duration and quality of subsequent repair de...
In silico analysis to explore the therapeutic potential of propolis-derived small molecules as matriptase inhibitors to suppress breast cancer growth and metastasis
Breast cancer is a major cause of death in women, and various drug therapies are used for its treatment. However, current therapies have many side effects and limitations. Propolis, a resinous product...
Medication adherence scales in non-communicable diseases: A scoping review of design gaps, constructs and validation processes
Introduction NCDs arise from complex interactions of modifiable factors such as unhealthy lifestyles, poor diet, and psychosocial challenges, along with non-modifiable factors like age and genetics. N...
Design, optimization, and ADMET evaluation of S11a-0000168202: A promising LIMK1 inhibitor for gastric cancer treatment
This study focuses on the development and optimization of S11a-0000168202, a novel LIMK1 inhibitor with potential therapeutic applications in gastric cancer. Through scaffold hopping and structural mo...
USS-Net: A neural network-based model for assisting flight route scheduling
Air traffic congestion-induced flight accidents pose a significant challenge in the aviation sector. Currently, aviation navigation systems primarily rely on GPS and Inertial Navigation Systems (INS)...
Mechanisms of synergy creation for social-ecological transformation: Leverage point analysis of the emergence of autonomous innovations
Transformation of social-ecological systems is required to overcome complex and difficult challenges and move forward toward sustainable futures for humanity and the environment. We have accumulated c...
Protective role of Lagenaria Siceraria seed oil against furan-induced toxicity: Histopathological, biochemical, and molecular insights in male Albino rats
This study aimed to assess the protective effects of Lagenaria siceraria seed oil (LSO) on fifty male Albino rats subjected to furan exposure. Furan (FU) is a small, heterocyclic compound present in t...
Characterisation of facial expressions and behaviours of horses in response to positive and negative emotional anticipation using network analysis
The welfare of an animal is closely linked to their emotional experiences, making it essential to identify reliable indicators of these emotions. This study aimed to identify behaviours and facial mov...
New technology for an ancient fish: A lamprey life cycle modeling tool with an R Shiny application
Lampreys (Petromyzontiformes) are an ancient group of fishes with complex life histories. We created a life cycle model that includes an R Shiny interactive web application interface to simulate abund...
Origin, trophic transfer and recycling of particulate organic matter in two upwelling bays of Humboldt Current System: Insights from compound-specific isotopic compositions of amino acids
The Chilean upwelling bays are highly productive ecosystems shaped by their interactions with the open ocean. Although significant knowledge exists regarding their hydrodynamic and ecological processe...
Hemostatic parameters in transgender women receiving gender-affirming hormone therapy: A shift to a cisgender female pattern?
Transgender women have an increased incidence of venous thromboembolism (VTE) compared with cisgender individuals. However, data on hemostatic parameters in this population are scarce. We aimed to eva...
Advancing patient care: Machine learning models for predicting grade 3+ toxicities in gynecologic cancer patients treated with HDR brachytherapy
Background Gynecological cancers are among the most prevalent cancers in women worldwide. Brachytherapy, often used as a boost to external beam radiotherapy, is integral to treatme...
Just another bike? Modelling the interdependence of conventional and electric bicycle ownership and the influence of topography using large-scale travel survey data from Germany
Electrical bicycle ownership rates are growing rapidly. Despite differences to conventional cycling, the two types of bicycles are generally not differentiated in travel demand modelling practice. Thi...
Complex nth power root fuzzy sets: Theory, and applications for multi-attribute decision making in uncertain environments
The newly introduced nth power root fuzzy set is a useful tool for expressing ambiguity and vagueness. It has an improved ability to manage uncertain situations compared to intuitionistic fuzzy set an...
Poverty alleviation policies, programs and practices for people with disabilities: A scoping review and recommendations
Background People with disabilities have a higher prevalence of living in poverty compared to people without disabilities, which largely results from the challenges, barriers, inequalities and discrim...
Geographical characteristics and formation mechanisms of smallpox epidemics in Hubei Province, China, 1488–1949
Smallpox is a highly contagious and ancient disease influenced by natural and social factors. These factors led to the wide spread of smallpox in Hubei Province of China during the historical period....
Parameters estimation of gas capture through Mixed Matrix Membrane (MMM) with CFD
Carbon dioxide (CO2) capture is a crucial process to mitigate greenhouse gas emissions and reduce anthropogenic impact on climate change. The 3-D model is choosing to capture carbon dioxide from real...
Healthcare utilization among patients with rheumatoid arthritis, with and without herpes zoster, a retrospective administrative data linked cohort study
Background Herpes zoster (HZ) infection is a significant concern among seniors and immunosuppressed patients including those with rheumatoid arthritis (RA). We aimed to compare healthcare utilization...
What emotions are elicited by smells in Japanese people? Emotional measurement using a universal scale in Japanese
Odors can elicit emotions, and cultural differences exist in the emotions elicited. To enable cross-cultural comparisons, the Universal Emotion and Odor Scales (EOS), a psychological scale consisting...
In vitro fermentation of yeast cell walls (mannan-oligosaccharide) and purified β-glucans modulates the colonic microbiota of dogs with inflammatory bowel disease and demonstrates protective effects on barrier integrity and anti-inflammatory properties
Inflammatory bowel disease (IBD) is characterized by a disruption of intestinal homeostasis, chronic inflammation, and dysbiosis. Prebiotic supplementation may be useful for managing IBD in dogs. The...
The association between circadian syndrome and possible sarcopenia in an aging population: A 4-year follow-up study
Introduction Recently, circadian syndrome (CircS) is proposed as a novel risk cluster based on sleep disorder, depression, dyslipidemia, hyperglycemia, hypertension and abdominal obesity. To investiga...
Characterization of the murine spine for spaceflight studies
Rodents provide a useful analog for understanding the effects of spaceflight on the human body, offering opportunities for investigations into the relationship between microgravity and the musculoskel...
Gram-negative bacterial sepsis, antimicrobial susceptibility pattern and treatment outcomes at two neonatal intensive care units in Addis Ababa, Ethiopia: A retrospective observational study
Background Neonatal sepsis is a leading cause of mortality and morbidity. To improve the clinical outcomes of neonates with sepsis, treatment should be based on bacteriological identification and anti...
Bridging the gap: A systematic review of intraoperative electrocochleography during cochlear implantation and preservation of residual hearing
Cochlear implantation is a surgical intervention to provide auditory rehabilitation to individuals with severe to profound hearing loss. Intraoperative electrocochleography (ECochG) has emerged as a p...
The neuroprotective role of CncC in a Drosophila model of Parkinson’s disease
Parkinson’s disease (PD) is an incurable neurodegenerative disorder, yet significant advancements have been made in understanding its etiology. Among the risk factors, exposure to neurotoxins plays th...