PLoS ONE
Articles in this Issue
The cost and health-related quality of life of stroke management and care of acutely hospitalized cases in Mozambique
Background Stroke is a leading cause of death and disability, placing a significant burden on survivors and their families. To address the lack of African-specific data, we investigated the cost of st...
Deep learning for pediatric chest x-ray diagnosis: Repurposing a commercial tool developed for adults
The number of commercially available artificial intelligence (AI) tools to support radiological workflows is constantly increasing, yet dedicated solutions for children are largely unavailable. Here,...
Data-driven personalized marketing strategy optimization based on user behavior modeling and predictive analytics: Sustainable market segmentation and targeting
Personalized recommendation remains a central challenge in modern marketing systems due to the complexity of user-product-query interactions. In this study, we propose a novel framework called DP-GCN...
A natural language processing approach to support biomedical data harmonization: Leveraging large language models
Background Biomedical research requires large, diverse samples to produce unbiased results. Retrospective data harmonization is often used to integrate existing datasets to create these samples, but t...
Analysis of logistics efficiency in Guangdong and its neighboring provinces based on the DEA-Malmquist index
With the development of economic globalization, logistics has become a crucial link in the global supply chain. In the backdrop of growing environmental concerns and the need for more efficient busine...
Genome-wide identification and characterization of m6A regulatory genes in Soybean: Insights into evolution, miRNA interactions, and stress responses
N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications in eukaryotes, playing a crucial role in plant development and stress responses. The m6A modification is regulated by three key...
Relationships between job characteristics and occupational well-being: Are they similar across levels of analysis?
Theory and practice in occupational health psychology have hitherto mostly assumed that how job characteristics relate to occupational well-being is similar across levels of analysis, yet this remains...
Quality criteria for evaluating creative and interactive science dissemination in public outreach efforts: A scoping review
Creative and interactive science dissemination is gaining recognition as an important component of public science communication, particularly in efforts to bridge the gap between science and society....
Decision factors for the selection of AI-based decision support systems—The case of task delegation in prognostics
Decision support systems (DSS) integrating artificial intelligence (AI) hold the potential to significantly enhance organizational decision-making performance and speed in areas such as prognostics in...
Efficacy and safety of ciprofol for the induction of general anesthesia in patients with obesity undergoing laparoscopic sleeve gastrectomy: A double-blind randomized, controlled study
Background The selection of safe and effective anesthetic agents for patients undergoing bariatric surgery is vital. This study aimed to evaluate the efficacy and safety of ciprofol in inducing genera...
The impact of anxiety and depression levels on the Big Five personality traits
Background The prevalence of stress, anxiety, depression and burnout is quite high in medical students, and they differ in terms of personality traits and self-perception. The Big Five Model has embra...
Sex disparities in papillary thyroid cancer survival: Divergent patterns of relative and absolute effects across the age spectrum
Purpose This retrospective cohort study aimed to reevaluate the prognostic impact of sex and determine whether age modifies the effect of sex on cancer-specific survival (CSS) in PTC patients. Metho...
Correction: Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells
Medicinal effects of Ephedra foeminea aqueous extracts: Metabolomic characterization, biological evaluation, and molecular docking
Ephedra foeminea Forssk. is a medicinal plant traditionally used across various cultures and recognized for its historical significance in herbal medicine. It has been used as an herbal infusion to tr...
A node influence ranking algorithm combining k-shell iteration and node degree
Identifying key nodes in complex networks holds significant application value in fields such as information dissemination and disease spread. The traditional K-shell decomposition method has low time...
Health implications of lower extremity amputations in Jordan: A retrospective analysis of demographic patterns and causes
Lower extremity amputation (LEA) is a significant health concern in Jordan, yet comprehensive data on its demographic and clinical characteristics remain limited. This retrospective analysis evaluated...
Cloning and enhancing lumbrokinase production from local Eisenia fetida by signal peptide engineering for effective thrombosis treatment
Thrombosis, the formation of blood clots in the circulatory system, is a major global health concern. Lumbrokinase, found in earthworms, is promising natural source of antithrombotic compounds. Tradit...
Sericin/polyvinyl alcohol hydrogel optimization for enhanced angiogenesis: a promising strategy for treating chronic osteomyelitis
Chronic osteomyelitis, often accompanied by bone loss, requires an adequate angiogenic response for bone regeneration. Loading growth factors into a drug vehicle to promote angiogenesis can address th...
A preliminary report on the feasibility of regression-based alignment of diagnostic thresholds for harmonized use of international classification criteria for antiphospholipid syndrome
Background In 2023, international rheumatology societies issued new classification criteria for antiphospholipid syndrome (APS). The criteria require scoring antiphospholipid antibody (aPL) titers as...
Multi-modal deep learning for intelligent landscape design generation: A novel CBS3-LandGen model
With the acceleration of the global urbanization process, landscape design is facing increasingly complex challenges. Traditional manual design methods are gradually unable to meet the needs for effic...
Secondary metabolites of the invasive tree, Callery pear (Pyrus calleryana), provide support for the empty niche theory of invasion
Invasive woody species like Callery pear (Pyrus calleryana Decne.) alter ecosystems directly and indirectly through effects on arthropod communities as well as chemical alterations of the soil. Eviden...
A multicenter study on rates and risk factors of proliferative vitreoretinopathy in a low-income economy
Objective To assess the rate and identify risk factors for proliferative vitreoretinopathy (PVR) in Nigerian patients with rhegmatogenous retinal detachment (RRD). Methods and analysis Multicenter,...
Spatial differentiation of productive services and its influencing factors: A case study of Kunming, China
The transition to a service-based economy represents a key global macroeconomic trend, with productive services playing a critical role in driving economic growth. For China, the development of produc...
Modelling students’ cognitive achievement skills using the alpha power transformed Lindley probability distribution
Cognitive achievements in mathematics skill scores are crucial for daily life in modern society. The objectives of this study were to apply the alpha power transformed Lindley probability distribution...
FedGAN: Federated diabetic retinopathy image generation
Deep learning models for diagnostic applications require large amounts of sensitive patient data, raising privacy concerns under centralized training paradigms. We propose FedGAN, a federated learning...