PLoS ONE
Articles in this Issue
Time-dependent predictors of loss to follow-up in HIV care in low-resource settings: A competing risks approach
Loss to follow-up (LTFU) remains a major challenge in HIV care, particularly in resource-limited settings. While several studies have identified its predictors, many have neglected the competing risks...
Performance and mechanism of waste engine oil in the regeneration of aged asphalt from different perspectives
To expand the utilization pathways of waste engine oil (WEO) and address the issues arising from road aging, this study investigates the regeneration effect of WEO as a rejuvenator for aged asphalt. T...
A dual-plane fluoroscope to track joint kinematics during dynamic daily activities
Accurate measurement of joint kinematics is a key requirement for understanding injury mechanisms, evaluate rehabilitation techniques, and improve the implant designs and techniques used in total knee...
Cost-effectiveness of biomarker-directed toripalimab plus chemotherapy for previously untreated extensive-stage small-cell lung-cancer in China
Background With or without biomarker-directed toripalimab plus chemotherapy could bring significant clinical benefit and acceptable safety profile compared with chemotherapy as first-line treatment fo...
Combined impacts of sea level rise and invasive species on Cordylanthus maritimus (Salt Marsh Bird’s Beak) in Upper Newport Bay, California
From Central California to Northern Baja California, Salt Marsh Bird’s Beak (Cordylanthus maritimus subsp. Maritimus; C. maritimus) is an annual hemiparasitic halophyte that is endemic to coastal salt...
Ownership succession, risk taking and debt financing from the perspective of the institutional environment
This study examines family firms listed on China’s A-share market, using a two-way fixed effects model to explore the impact of ownership succession on debt financing and the moderating role of the in...
Clinical outcomes of a novel single-stage cartilage repair technique using calcified cartilage zone debridement with hyalofast
Introduction This study aims to determine the clinical outcomes of a new technique of cartilage repair surgery, using calcified cartilage zone debridement coupled with Hyalofast and bone marrow aspira...
Assessing quantitative MRI techniques using multimodal comparisons
The study of brain structure and change in neuroscience is commonly conducted using macroscopic morphological measures of the brain such as regional volume or cortical thickness, providing little insi...
cONcat: Computational reconstruction of concatenated fragments from long Oxford Nanopore reads
Synthetic combinatorial DNA libraries are widely used to produce protein variants, optimize binders, and for high-throughput studies of protein-DNA interactions. The libraries can be made by researche...
Pathways to psychiatric care in Debre Berhan, Ethiopia: A cross-sectional study
Background Pathways to care are the steps individuals went through before finally consulting formal psychiatric services. In developing countries, people with mental disorders (PWMDs) often first cons...
Measuring negative emotions and stress through acoustic correlates in speech: A systematic review
Speech analysis offers a non-invasive method for assessing emotional and cognitive states through acoustic correlates, including spectral, prosodic, and voice quality features. Despite growing interes...
Biomechanical analysis of hip, knee, and ankle joint contact forces during squats in elite powerlifters
The squat is one of three lifts within the sport of powerlifting. This study examined how increasing intensity in the squat affects joint contact forces in elite powerlifters. Twenty-nine Austrian top...
Reasoning action-centric temporal relations at rich feature hierarchies for action recognition
Reasoning temporal relations among action-related objects plays an important role in action recognition. However, previous approaches only focus the reasoning on high-level semantics and inevitably in...
Evaluating GPT-4’s role in critical patient management in emergency departments
Introduction Recent advancements in artificial intelligence (AI) have introduced tools like ChatGPT-4, capable of interpreting visual data, including ECGs. In our study,we aimed to investigate the eff...
Whole blood transcriptomics analysis of Indonesians reveals translocated and pathogenic microbiota in blood
Pathogens found within local environments are a major cause of morbidity and mortality. This is particularly true in Indonesia, where infectious diseases such as malaria or dengue are a significant pa...
Blood pressure variability combined with coagulation function in early prediction and outcome assessment of germinal matrix-intraventricular hemorrhage in preterm infants with gestational age ≤32 weeks
Objective To determine the association between blood pressure variability (BPV), coagulation indexes, and germinal matrix-intraventricular hemorrhage (GMH-IVH) in preterm infants with gestational age ...
Prevalence, species identification, and antibiotic resistance of Staphylococci in dogs visiting veterinary clinics in Vietnam
Staphylococci are important commensal and opportunistic bacteria found in various animals, including dogs and humans. The emergence of antibiotic-resistant Staphylococci is a growing global concern, i...
New bounds of the smoothing parameter for lattices
The smoothing parameter on lattices is crucial for lattice-based cryptographic design. In this study, we establish a new upper bound for the lattice smoothing parameter, which represents an improvemen...
Expanding risks: Medicaid expansion and data security
The Patient Protection and Affordable Care Act of 2010 led to the largest expansion of healthcare coverage since the instantiation of Medicare and Medicaid in 1965. Concerningly, prior research sugges...
Bayesian mediation analysis using patient-reported outcomes from AI chatbots to infer causal pathways in clinical trials
The integration of artificial intelligence (AI) chatbots into clinical trials offers a transformative approach to collecting patient-reported outcomes (PROs). Despite the increasing use of AI chatbots...
Therapeutic itineraries and testimonies of COVID-19 patients in Manaus, the epicenter of the pandemic in the Brazilian Amazon
Introduction Therapeutic itineraries (TIs) involve the process of choices and the evaluation of care/treatment experiences related to the family, popular and professional subsystem...
Comprehensive characterization of the competitive endogenous RNA network revealing its immune-related functions in hepatic ischemia-reperfusion injury
Hepatic ischemia-reperfusion injury (HIRI) is a common complication in liver surgery and transplantation. Recent studies have revealed the significant role of the competing endogenous RNA (ceRNA) netw...
Research on optimization of C4 repair operation of Harmony electric locomotive based on preventive maintenance
Harmonious High-Power AC Electric Locomotive, as the main type of locomotive for freight transport in China, the safety of its operation and maintenance issues have been the focus of great attention b...
SERPINH1 functions as a multifunctional regulator to promote the malignant progression of cervical cancer
Cervical cancer remains the second leading cause of female cancer mortality worldwide, with metastasis representing a critical therapeutic challenge. This study systematically reveals the key role of...
Serum 25(OH)D levels and mortality risk among middle-aged and elderly populations in the U.S.: A prospective cohort study
Objective To investigate the prevalence of vitamin D deficiency and its relationship with all-cause and cause-specific mortality among middle-aged and elderly populations in the U.S. Methods Data we...