PLoS ONE
Articles in this Issue
Identification of silibinin and isotretinoin as potent up-regulators of sFRP4 (Wnt antagonist): In silico prediction and in vitro validation in breast cancer
Secreted frizzled-related protein 4 (sFRP4) plays a fundamental role in the regulation of Wnt signalling, which is crucial for cellular proliferation and differentiation. The sFRP4 has garnered signif...
SAMCell: Generalized label-free biological cell segmentation with segment anything
Background: When analyzing cells in culture, assessing cell morphology (shape), confluency (density), and growth patterns are necessary for understanding cell health. These paramet...
Experimental study on polymer friction composite with natural friction modifiers for brake pads
The increasing concern over environmental pollution from brake dust and the adverse impacts of conventional brake pad materials, such as metallic, semi-metallic, and ceramic composites, has prompted t...
Earmarking donations to boost study participation? Evidence from a field experiment
Charitable donations are often the most suitable available way to incentivize study participation, yet their optimal design remains unclear. In a preregistered field experiment, we invited 6,711 psych...
Normative serum cortisol levels in second and third trimesters and their associated factors: A prospective cohort study from Sri Lanka
Objective To describe the normative serum cortisol levels during 25–29 weeks of POG and the association of maternal, psychological, and social factors on serum cortisol in the seco...
Prospects for silvicultural enhancement of fire resistance in mesic westside forests of the Pacific Northwest
Increasing wildfire activity in mesic, temperate Pacific Northwest forests west of the Cascade Range crest has stimulated interest in understanding whether alternative forest management practices coul...
Compartment-specific adaptive responses and dysregulation under NQO1 deficiency in diabetic kidney disease: A transcriptomic GSEA-based investigation
Diabetic kidney disease (DKD) involves oxidative stress–driven damage to glomeruli (Gloms) and proximal convoluted tubules (PCT). NAD(P)H: quinone oxidoreductase 1 (NQO1) regulates redox balance, but...
Superior health-related physical fitness and well-being in 12–15-year-old Danish adolescents who are active in organized leisure-time sports – a cross-sectional study
Background Global reports indicate that less than 20% of 11–17-year-olds meet physical activity recommendations, and while organized sports participation increases the likelihood of meeting these guid...
Measuring the synergy between technological and management innovation in megaprojects: Empirical evidence from China
In the national innovation system, the synergistic development of technological and management innovation in megaprojects plays a critical role in achieving high-quality project delivery. This study a...
Mindfulness beyond secularization: Beliefs across meditators and non-meditators reflect a consensus on personal development over health and spirituality
Background Mindfulness meditation (MM), originating from spiritual traditions but widely promoted as a secular and beneficial practice, is increasingly debated due to potential adverse effects, ethica...
Impact of stress and coping strategies on quality of life in hematological malignancies: A cross-sectional study
Background and aims While perceived stress and coping strategies have been established as significant determinants of quality of life (QoL) in patients with solid malignancies, their impact on hematol...
Correction: Ictal cardiovascular autonomic dysfunction during focal seizures induced by direct electrical stimulation: An observational study research protocol
Automated segmentation of retinal vessel using HarDNet fully convolutional networks
Computer-aided diagnostic (CAD) systems for color fundus images play a critical role in the early detection of fundus diseases, including diabetes, hypertension, and cerebrovascular disorders. Althoug...
Non-thermal plasma activated water is an effective nitrogen fertilizer alternative for Arabidopsis thaliana
Nitrogen (N) fixation with non-thermal plasmas has been proposed as a sustainable alternative to meet growing N fertilizer demands for agriculture. This technology generates Plasma Activated Water (PA...
Understanding the role of Shroom3 in the developing mouse myocardium
Loss of actin cytoskeleton control can hinder integral developmental and physiological processes and can be the basis for a subset of developmental defects. SHROOM3 is an actin binding protein, best c...
Hepatitis C virus reinfection among people who inject drugs in the country of Georgia and injection-related risk factors: Implications for HCV elimination in the EECA region
Hepatitis C (HCV) infection is a major global health challenge, with particularly high prevalence among people who inject drugs (PWID) in the Eastern European and Central Asian region (EECA). While th...
A correlation analysis between nutritional status and physical function in the elderly with pulmonary tuberculosis
Background Malnutrition is a significant risk factor contributing to the progression of the elderly with pulmonary tuberculosis (TB). This study aimed to evaluate the nutritional status of the elderly...
Patient capital and green total factor productivity: Evidence from Chinese listed companies
This study applies Fisher’s investment framework to investigate how patient capital affects firms’ green total factor productivity (GTFP). Using panel data from Chinese listed companies over the perio...
Improved protocol for the vitrification and warming of rat zygotes by optimizing the warming solution and oocyte donor age
Zygotes are used to create genetically modified animals by electroporation using the CRISPR-Cas9 system. Such zygotes in rats are obtained from superovulated female rats after mating. Recently, we rep...
18 individual genes underwent variant screening in a northwest Chinese group comprised 83 probands diagnosed with early-onset high myopia
Purpose To investigate the variants in 18 disease-causing genes associated with nonsyndromic myopia in 83 Chinese individuals diagnosed with early-onset high myopia(eo-HM). Methods Variants in 18 ca...
Effects of yeast beta-1,3/1,6-glucans on nutrient digestibility, intestinal functionality, and immune and antioxidant variables in growing dogs submitted to spay or neutering surgery
This study aimed to assess the impact of yeast beta-1,3/1,6-glucans (BG) on apparent digestibility coefficients (ADC) of nutrients, intestinal fermentative metabolites, fecal microbiota profile, and i...
Correction: Global socio-economic losses and environmental gains from the Coronavirus pandemic
Sedentary behavior mediates the association between weight-adjusted waist index and cardiovascular disease in patients with diabetes
Background Obesity and cardiovascular disease (CVD) are both associated with sedentary behavior. However, the role that sedentary behavior plays in the relationship between obesity and CVD in patients...
The mediating role of hope in the relationship between purpose in life and anxiety: A cross-cultural analysis in university students
Objective To examine the direct effect of purpose in life (PIL) on anxiety and its indirect effect through hope in a sample of university students from Ecuador, Bolivia, and Colombia, while assessing...
Looking beyond digital broadband speeds: Rural British Columbian’s experiences with internet connectivity as a basic necessity
Aim This study examined the experience of digital connectivity among rural-living British Columbians both with and without access to high-speed Internet at home. Background Evidence indicates that f...