PLoS ONE
Articles in this Issue
Southern European Prospective Investigation Into Childhood Cancer and Nutrition (EPICkids): Study design and protocol
The survival rates for children with cancer have increased appreciably over the last few decades; however, childhood cancer survivors continue to suffer from long-lasting sequelae. Studies have demons...
Gene expression profiling and pathway analysis in acute myeloid leukaemia-normal karyotype patients
Acute myeloid leukaemia-normal karyotype (AML-NK) exhibits heterogeneity in expression profiles, influencing the treatment response and survival outcome. Transcriptome sequencing allows a comprehensiv...
In Vitro synergy of Farnesyltransferase inhibitors in combination with colistin against ESKAPE bacteria
The emergence of antibiotic resistance continues to pose a significant global challenge. Drug repurposing, wherein existing therapeutics are evaluated for new applications, offers a promising strategy...
Bank complexity and core competence of commercial banks in Vietnam: The buffer role of corporate social responsibility
Based on stakeholder theory, socially responsible practices may help firms gain competitive advantages by lowering operational costs and enhancing their core competencies. From the perspective of the...
Comparison of peripheral venous and arterial blood gas in management of patients with respiratory complaints in the emergency department: A prospective observational cohort study
Introduction Although peripheral venous blood gas (pVBG) analysis is used in the Emergency Department (ED), its effect on clinical decision making is unknown. We assessed whether pVBG analysis combine...
Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation
The farnesoid X receptor (FXR), expressed in the liver and in the small intestine, is a key regulator of glucose and lipid metabolism. Its pharmacological modulation is explored as a potential treatme...
Genetic and economic efficiencies of alternative breeding schemes for improvement of local breeds in low-input production systems: The case of the Farta sheep in Northwest Ethiopia
Designing and implementing a sound breeding program is essential for sustainably improving livestock productivity. This study evaluated the efficiencies of three breeding schemes for sustainable genet...
Genetic data and meteorological conditions suggesting windborne transmission of H5N1 high-pathogenicity avian influenza between commercial poultry outbreaks
Understanding the transmission routes of high-pathogenicity avian influenza (HPAI) is crucial for developing effective control measures to prevent its spread. In this context, windborne transmission,...
RETRACTED: Unlocking the power of L1 regularization: A novel approach to taming overfitting in CNN for image classification
Convolutional Neural Networks (CNNs) stand as indispensable tools in deep learning, capable of autonomously extracting crucial features from diverse data types. However, the intricacies of CNN archite...
How fake news can turn against its spreader
When different information sources on a given topic are combined, they interact in a nontrivial manner for a rational receiver of these information sources. Suppose that there are two information sour...
Expression of hormonal receptors and Toll-like receptors in cultured canine uterine explants with pseudoplacentational endometrial hyperplasia and bacterial-elicited endometrial inflammation
Pseudoplacentational endometrial hyperplasia (PEH) is a common uterine lesion in dogs. A high frequency of pyometra has been associated with PEH in dogs, suggesting that PEH might be related to the pa...
The role of intrinsic motivation in sustaining citizen science participation among diverse participants in a corporate volunteer program
Citizen science enables volunteers from the public to contribute to scientific research. While citizen science may be an avenue for “democratizing” science and facilitating learning among volunteers,...
Formulation of silages from spent mushroom substrates of Pleurotus ostreatus and Lentinula edodes: Organoleptic properties, phenolic content, in vitro digestibility, gas production and ruminal kinetics
To fulfill the global demand for sustainable livestock production and the implementation of circular economy models, the search for alternative feed sources to lower production cost has increased sign...
Chemical characterization and antimicrobial activities of Citrus aurantifolia peel oils and Ocimum sanctum ethanolic extract
Oral diseases affect more than 3.5 billion people globally, representing a major public health burden, particularly in low- and middle-income countries where access to dental care is often limited. Fu...
Highly stressful global event affecting health sciences students: A longitudinal qualitative study
Background Stressful events of great magnitude have produced significant changes in society and in health education. University students have faced considerable challenges both during and after such e...
Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer’s Disease, followed by molecular docking studies
Alzheimer’s disease (AD) is a neurodegenerative disorder categorized by the progressive loss of cognitive function, with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) as key therapeuti...
Correction: Identification and validation of a m7G-related lncRNA signature for predicting the prognosis and therapy response in hepatocellular carcinoma
Role of mTORC1 signaling in postnatal microglia activation preceding neurodegeneration in a mouse model for Niemann-Pick disease Type C
In Npc1 deficient mice, postnatal developmental alterations in cerebellar microglia and Purkinje cells (PCs) are followed by early-onset neurodegeneration. Even in the absence of PC loss, microglia in...
Fatigue characteristics and mechanism of phosphogypsum stabilised red clay under dry and wet cycles
Phosphogypsum is an acidic solid waste mainly composed of CaSO₄-2H₂O by-products of the wet process phosphoric acid industry, which has the characteristics of high impurity content, poor stability of...
Relationship of vitamin D, fibrinogen and their ratio with acute coronary syndrome: A comparative analysis of unstable angina, NSTEMI, and STEMI
Background There is emerging evidence suggesting that vitamin D and fibrinogen play contrasting roles in ACS pathophysiology and their combined impact, expressed as the vitamin D/fibrinogen ratio, can...
The effect of digital media on college students’ sports participation: The mediating role of sports cognition and the moderating role of self-efficacy
Background With the increasing integration of digital media into daily life, its influence on college students’ sport-related behaviors has become a growing area of interest. While prior research high...
The impact of breast cancer awareness campaigns on the knowledge, attitudes, and practices of breast cancer screening among Saudi female employees
Background Breast cancer (BC) stands as a significant and prevalent malignancy impacting women. The increase in statistics is primarily due to delayed detection, often attributed to a lack of awarenes...
Association between receiving the Aksi Bergizi Social Behavioral Change Communication (SBCC) intervention and dietary habits among secondary school students in Padang, Indonesia
Background The Government of Indonesia and UNICEF introduced the Aksi Bergizi Social Behavioral Change Communication (SBCC) intervention to promote healthy dietary behaviors among adolescents. However...
Iterative rolling difference-Z-score and machine learning imputation for wind turbine foundation monitoring
In engineering structure performance monitoring, capturing real-time on-site data and conducting precise analysis are critical for assessing structural condition and safety. However, equipment instabi...
Evolutionary dynamics in plastomes and mitogenomes of diatoms
Diatoms are pivotal in global oxygen, carbon dioxide, and silica cycling, contributing significantly to photosynthesis and serving as fundamental components in aquatic ecosystems. Recent advancements...