PLoS ONE
Articles in this Issue
Examining models of telemedicine use among U.S. physicians during the COVID-19 pandemic
The purpose of this study is to apply the theory of reasoned action (TRA) and technology acceptance model (TAM) to U.S. physicians’ adoption of telemedicine during the COVID-19 pandemic. A total of 23...
Multi-modal virtual reality system for tinnitus treatment methods and validation
Virtual reality (VR) has been utilized in clinical treatment because it can efficiently simulate situations that are difficult to control in the real world. In this study, we evaluated the efficacy of...
“Colorectal Cancer Care Quality in a Developing Country: Insights from a Comparison of Teaching and Non-teaching Hospitals in Iran”
Background Our study represents the first effort in the Eastern Mediterranean Region to identify disparities in the quality of colorectal cancer (CRC) care in Iran. Methods We established a collabor...
Antibodies raised against a structurally defined Aβ oligomer mimic protect human iPSC neurons from Aβ toxicity at sub-stoichiometric concentrations
Anti-Aβ antibodies are important tools for identifying structural features of aggregates of the Aβ peptide and are used in many aspects of Alzheimer’s disease (AD) research. Our laboratory recently re...
Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus
In adult mammals and other highly developed animals, incomplete wound healing, scar formation, and fibrosis occur. No treatment for complete tissue regeneration is currently available. However, in mic...
Effect of C-reactive protein and serum amyloid A point-of-care testing on antibiotic prescribing for acute respiratory-tract infections at village clinics in China: A study protocol for a cluster randomised controlled trial
Background Antimicrobial resistance is a globally recognised public health threat. In rural China, antibiotic use is common for acute respiratory infections (ARIs), which include symptoms such as coug...
Assessment of community livelihood vulnerability to climate change in Vietnam: A case study of ethnic groups in Northern Upland Region
This study aims to assess the livelihood vulnerability to climate change of ethnic minority communities in Yen Bai province, a typical mountainous region in northern Vietnam. Utilizing the Livelihood...
Exploring extreme environments in Türkiye for novel P450s through metagenomic analysis
Cytochrome P450 enzymes (P450s), particularly those of microbial origin, are highly versatile biocatalysts capable of catalyzing a broad range of regio- and stere-oselective reactions. P450s derived f...
Echocardiographic findings in young adults with primary hypertension: A scoping review protocol
Echocardiography is the primary imaging tool for evaluating cardiac structure and function in patients with primary hypertension. A significant limitation of the current literature is that most studie...
Correction: Distribution of Anopheles stephensi bioforms in selected districts of Rajasthan, India
The impact of driving versus undistracted listening on podcast knowledge acquisition and retention using a driving simulator: A randomized, cross-over trial
Introduction Research on listening to podcasts while driving suggested no significant difference compared to undistracted listening. However, these studies were conducted in non-controlled driving env...
Rapid response to hemorrhagic fever emergence in Guinea: community-based systems can enhance engagement and sustainability
Since the 2013–2014 Ebola virus disease outbreak, Guinea has faced recurrent epidemics of viral hemorrhagic fevers. Although the country has learned from these epidemics by improving its disease surve...
Interferon-gamma 1b-induced gene expression alters neutrophil function in patients with chronic granulomatous disease
Interferon-gamma (IFN-γ) decreases infections in chronic granulomatous disease (CGD) with variably incomplete restoration of the fundamental CGD defect, converting oxygen to microbicidal oxidants duri...
Circulating metabolites in patients with chronic heart failure are not related to gut leakage or gut dysbiosis
Background The gut microbiota produces numerous metabolites that can enter the circulation and exert effects outside the gut. Several studies have reported altered gut microbiota composition and circu...
Diversity on the bench: An analysis of gendered biases in the language of Australian Family Law Court judgments
In this paper we analyse gender-based biases in the language within complex legal judgments. Our aims are: (i) to determine the extent to which purported biases discussed in the literature by feminist...
The effect of exogenous melatonin and melatonin receptor agonists on intensive care unit and hospital length of stay: A systematic review and meta-analysis
Introduction Melatonin supplements and melatonin receptor agonists are linked to reduced delirium in the Intensive Care Unit (ICU) which we hypothesised may affect the length of stay (LOS) in ICU or i...
Vitamin D3 reduces the viability of cancer cells in vitro and retard the EAC tumors growth in mice
Prior studies from our laboratory have shown that cancer cells exposed to vitamin D3 exhibited reduced proliferation in breast cancer cells due to the upregulation of p53 and downregulation of cyclin-...
When automation hits jobs: Entrepreneurship as an alternative career path
This study investigates the relationship between occupational automation risks and workers’ transitions to entrepreneurship using data from the Current Population Survey. We find that employees facing...
What is known from the existing literature about adolescent knowledge and attitudes towards dementia and interventions to enhance this? A scoping review
Objectives Individuals with dementia often experience stigmatisation and social exclusion. To develop dementia-friendly communities, it is important to take a life-course approach to enhance the perce...
Trends in gestational age at birth in the city of São Paulo, Brazil between 2012 and 2019
Studies have shown that excessive obstetric interventions such as induced labor and caesarean sections have contributed to the shortening of the length of gestation, leading to a left shift in gestati...
Cost-effectiveness of oil and milk fortification by scale for reducing Vitamin A and Vitamin D deficiency in India
Background Although broad-scale data might suggest low prevalence, millions of children in India still suffer from Vitamin A and Vitamin D deficiencies despite India’s existing guidelines for Vitamin...
A study of the binary marginal effect of technical barriers to trade on the export of shellfish and aquatic products in China
This study aims to examine the impact of technical barriers to trade (TBT) on China’s shellfish exports, focusing on both the intensive margin (trade volume) and the extensive margin (trade type). The...
Incidence of depression and anxiety in children and adolescents following COVID-19 infection
While the COVID-19 pandemic has significantly impacted mental health, limited information exists on the relationship between COVID-19 infection and mental health disorders in children and adolescents....
Modelling taxi drop-off decisions in FIFO lanes via survival and discrete choice analysis
Traffic congestion frequently occurs in the drop-off zones of large integrated passenger hubs, posing significant challenges to the efficient utilization of lane space. This study develops a First-In-...
Pinoresinol enhances oral barrier integrity and function in human buccal cell monolayers
The oral epithelial barrier plays a crucial role in maintaining oral health by protecting against microbial invasion and mechanical stress while regulating selective permeability. Disruption of this b...