PLoS ONE
Articles in this Issue
A deep learning model to enhance lung cancer detection using ‘Dual-Branch’ model classification approach
Cancer remains a life-threatening global challenge, with lung cancer ranking among the most devastating forms, impacting millions annually. Early detection and accurate classification are essential fo...
Endocrine advantages of PD-1/PD-L1 therapy: Comparative analysis of FAERS-JADER
With the extensive clinical application of immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs) associated with these agents have increasingly garnered significant attention. Unl...
SlATG8f modulates tomato thermotolerance and fruit quality, correlating with changes in autophagy and heat shock-related genes
Plant responses to high-temperature stress involve intricate changes in physiology bio-chemistry, and gene expression. Autophagy, a conserved intracellular degradation system, aids in eliminating dama...
Interactions between ionizing radiation and Vairimorpha (Nosema) ceranae on the honeybee, Apis mellifera L.
The global decline of honeybee colonies represents a major ecological concern, primarily attributed to simultaneous exposure to multiple stressors. These include biotic pressures, such as parasitic in...
Impact of combined medication payment management policies on population health performance
This study investigated the mechanism and impact of a policy combination involving centralized drug procurement and national drug price negotiations on health insurance payment management and overall...
Integrated forecasting and deep reinforcement learning for price-based self-scheduling of PV-BESS: Utility-scale evidence in Chile
Deep Reinforcement Learning (DRL) shows good performance for optimizing battery energy storage systems (BESS) coordinated operations with photovoltaic plants (PV), yet most studies rely on simulations...
Mosquito seasonality and trap type evaluation using routine surveillance data from New Orleans, Louisiana, United States
New Orleans, Louisiana, is a major gateway for the introduction of arboviruses into the United States due to high volumes of travel from arbovirus-endemic regions, the influx of migratory birds, and t...
“Kuchoka”: Investigation of research fatigue in Mosoriot, Kenya
Background Health research is key to the promotion of population and community health, however, conducting many research studies in a community can cause research fatigue....
Comparison of four diagnostic indices for metabolic syndrome in a Northern Spanish population
Cardiometabolic diseases are the leading cause of death worldwide, and early identification of individuals at risk is essential to reduce their burden. This study compared the performance of four diag...
Dynamic grasping system based on visual algorithm and robot arm collaboration in logistics production line
In response to the urgent need for efficient and accurate dynamic grasping in automated logistics, this study proposes the VRCDS, a dynamic grasping system that integrates a multi-feature weighted PnP...
Beyond the perception of present economic inequality: How people construe past, present and future wealth gaps
People tend to misperceive economic inequality levels in their country. However, studies investigating such misperceptions focused mainly on appraisals of present inequality. In two cross-sectional st...
Comprehensive transcriptome and metabolome analysis to exploration the effects of TCs on GCs lipid metabolism at goose pre-ovulatory follicle
Granulosa cells (GCs) and theca cells (TCs) have complex communication and interactions. Lipid metabolism in GCs is important for follicle development, which is also inseparable from the role of TCs;...
Delivering culturally adapted family interventions for people with schizophrenia in Indonesia: A feasibility randomised controlled trial and nested process evaluation
Schizophrenia is a severe and enduring illness with high relapse rates leading to functional impairment. Although family interventions effectively reduce relapse, most evidence originates from high-in...
Accurate radiographic interpretation of misfit milled zirconia crowns of different designs: An in vitro study
Prosthodontists often assess crown margins clinically and radiographically. However, judging an open crown margin clinically is difficult, and their radiographic assessment is controversial. The objec...
Retraction: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption
Separate and unequal: Moral domains differ in corresponding social judgments of others
Current research on morality supports the idea that the moral landscape is comprised of several domains. However, the extent to which these domains may be thought of as equivalent when used as the bas...
Differences in soil carbon fractions and microbial communities and their underlying mechanisms between assisted natural regeneration and plantation forests in subtropical China
Subtropical forests are critical to regional carbon cycling, yet the mechanisms by which forest management practices influence soil organic carbon (SOC) stability are not yet fully understood. This st...
Microbial profile along the maternal-infant axis: Early characterization and relationships in breastfeeding women and their newborns in a Colombian population
Objective To characterize the maternal-infant microbiota and examine microbial relationships among the maternal gut, human milk, and infant gut microbiomes in a cohort of Colombian...
Genetic analysis of LRRK2 variants in Han Chinese patients with Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, with variants in the leucine rich repeat kinase 2 gene ( LRRK2 ) being frequent g...
Improved YOLOv8-SST for accurate detection of small floating objects in complex water environments
In response to the urgent need for water environment protection, this study proposes an improved algorithm for detecting floating objects on the surface of water: You Only Look Once version 8- Small S...
Gender-transformative health promotion interventions for linking and retaining tuberculosis-diagnosed adult men in care in sub-Saharan Africa: A scoping review protocol
Tuberculosis (TB) remains a leading cause of infectious disease mortality globally, with men in sub-Saharan Africa (SSA) disproportionately affected. Men experience higher TB incidence, delayed care-s...
Effects of maternal BMI on early pregnancy endocrine–metabolic function and offspring development: Evidence from a retrospective cohort and animal model
Objective Abnormal body mass index (BMI) has been associated with pregnancy complications and adverse pregnancy outcomes; however, its clinical significance during early pregnancy...
The nose knows: Thermal responses to active psychological stressors
Stress is an essential component of our lives. It helps to us to keep alert, stay motivated, and adapt to new and challenging situations. However, it is also a leading cause of poor mental wellbeing....
Genetic diversity and population structure in Ethiopian Urochloa brizantha genotypes uncovered using inter simple sequence repeat (ISSR) markers
Urochloa brizantha is a tropical C4 grass belonging to the Urochloa genus. Despite its immense potential as animal feed and its contribution...
Mobile health supported real-time guidance and debriefing for newborn resuscitation: A pilot study of LIVEBORN feedback
Basic resuscitation practices, particularly bag-mask ventilation, reduce newborn deaths from respiratory depression. There is strong scientific premise for improving bag-mask ventilation with feedback...