PLoS ONE
Articles in this Issue
Graph former-CL: A novel graph transformer with contrastive learning framework for enhanced drug-drug interaction prediction
Drug-drug interactions (DDI) represent a significant clinical challenge in modern healthcare, contributing to over 125,000 deaths annually in the United States alone. Current computational approaches...
In vitro assessment of antibacterial and biocompatibility properties of a poly-ε-lysine and hyaluronic acid contact-killing coating to prevent prosthetic joint infection
Prosthetic joint infection (PJI) is a major adverse outcome following total hip and knee arthroplasties. With the rise of antimicrobial resistance, there is a risk of therapeutic insufficiency in trea...
A novel approach for longitudinal analysis of serum biomarkers of joint metabolism and knee injury in military officers
Purpose To investigate the longitudinal relationships between serum biomarkers of joint metabolism, knee injury, and Knee Injury and Osteoarthritis Outcome Score (KOOS) using novel...
A randomized controlled trial in healthy participants to compare the insulinogenic effects of whey protein and pea protein co-ingested with glucose
Increasing protein content of foods is effective in reducing postprandial hyperglycaemia, but animal protein may exacerbate insulin sensitivity. This single-blind, randomised, crossover study compared...
Effectiveness of dyadic interventions in improving outcomes for adults with multiple long-term conditions and/or frailty and their informal carers: A systematic review protocol
Aim To synthesise current evidence on the effectiveness of dyadic (pair-based) interventions in improving outcomes for adults with multiple long-term conditions (MLTC) and/or frail...
Evaluating the effect of the SMART intervention in people with recently diagnosed breast cancer who are being treated at a public tertiary hospital in Australia: protocol and statistical analysis plan for a single-blinded, single centre randomised controlled trial
Introduction Adults undergoing treatment for breast cancer (BC) are advised to participate in regular exercise. However, many struggle to exercise consistently due to the side effe...
Correction: Absence of ultimate controller and investment efficiency: Evidence from China
Households’ poverty and inequality after the COVID-19: Insights from panel data of face-to-face surveys in Southeast Asia
The global COVID-19 pandemic has had catastrophic impacts on global economies and human health. The consequences of the COVID-19 pandemic include the fatalities of millions of people and increased pov...
Spinal cord perfusion pressure protocol for acute spinal cord injury: Pragmatic implementation and early results at two sites
Study design Retrospective chart review. Objective Describe safety/feasibility of implementing a novel...
Transcriptome profiling indicates varied gene responses to Pasteurella multocida mutant infections in cattle
Pasteurella multocida is a pathogen that causes bovine respiratory disease, and the development of an effective vaccine is important for improving animal health. Live-attenuated va...
Streptococcus pneumoniae upregulates Toll2, Toll9, and defensin genes in Bombyx larvae infection model
Pneumococcal diseases caused by the human pathogenic bacterium Streptococcus pneumoniae are a major public health concern worldwide. In this study, we examined...
Communication and coordination as drivers of safety behaviours and outcomes in coal-fired power plants
Effective communication and coordination are vital for promoting safety in high-risk industries. While widely regarded as key drivers of safety behaviour, their direct and indirect effects on safety o...
Infection prevention practices and associated factors among healthcare professionals in West Gojjam Zone public Hospitals Northwest Ethiopia, 2023
Background Inadequate adherence to infection prevention and control standards places millions of patients and healthcare workers at risk of infectious diseases worldwide, including...
Synthesis of new benzothiazole derivatives with in-depth In-vitro, In-vivo anti-oxidant, anti-inflammatory and anti-ulcer activities
Benzothiazoles (BTZ) possess various medicinal benefits and in this study, we have synthesized benzothiazole derivatives by substituting its side chains, and analyzed its spectral analysis along with...
Correction: Measuring novelty in science with word embedding
Correction: Predicting unsafe behaviour from the objective assessment of fatigue manifestation among scaffolders: Evidence from a Quasi-experimental simulation study
High-dimensional phenotyping reveals novel macrophage-like and hybrid subsets within murine splenic conventional dendritic cells
Conventional dendritic cells (cDCs) are pivotal antigen-presenting cells (APCs) with critical roles in immune regulation, yet their subset classification remains ambiguous due to phenotypic overlap wi...
The autonomy paradox in AI-generated content adoption: Creative-specific alternative to TAM model in China’s micro-short drama industry
In China’s booming micro-short drama industry, Artificial Intelligence Generated Content (AIGC) presents creators with an ‘autonomy paradox’: improving efficiency while sparking fears of lost control,...
Biochemical metabolic enhancement acting as a dominant driver in intra-leaf CO2 diffusional response to soil nitrogen supplying in Soybean
Biochemical metabolism and anatomical structure within leaf tissues have been proposed as the two principal mechanisms underpinning the rapid responsiveness of mesophyll conductance (...
DMS-YOLO: Small target detection algorithm based on YOLOv11
To address the challenges in vehicle detection from unmanned aerial vehicle (UAV) overhead images, such as small object size, low resolution, complex background, and scale variation, this paper propos...
First report of extended-spectrum beta lactamase (ESBL) and carbapenemase-producing MDR Klebsiella pneumoniae from Fuchka
Extended-spectrum beta-lactamase (ESBL) and Carbapenemase-producing Gram-negative bacteria, particularly Klebsiella pneumoniae (ESBL-KP and CP-KP), in the food...
Intergenerational transmission of violence in Bangladesh: Mediated through maternal attitudes towards intimate partner violence, disciplinary beliefs, and life satisfaction
Introduction Child discipline, while intended to instill appropriate behavior, often manifests as violent practices in low- and middle-income countries, including Bangladesh. Mater...
Rare event detection by progressive clustering undersampling
Capturing rare events in severely imbalanced datasets is challenging, as the learning and optimization processes are often biased toward the majority class. To address this issue, this study explores...
Optimization of decompression angles in facial nerve decompression surgery: A decompression model
Facial nerve decompression is a surgical procedure performed for severe facial nerve paralysis associated with conditions such as Bell’s palsy and Ramsay Hunt syndrome. Classical Western studies by Fi...
Morphological traits and microbiome diversity in the free-living nematodes Acrobeles complexus and Zeldia punctata
Morphological adaptations play a key role in shaping the feeding behavior and microbiome associations of Cephalobidae nematodes. To investigate how morphology influences nematode-associated microbiome...