PLoS ONE
Articles in this Issue
Inhibition of TREM1 attenuates myocardial ischemia-reperfusion injury-induced cardiomyocyte pyroptosis by suppressing the activation of the NF-κB signaling pathway
Background Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of inflammatory responses and plays a critical role in the pathogenesis of various infect...
Characterization of extended-spectrum cephalosporin-resistant Klebsiella recovered from dairy manure in Southern Ontario, Canada
Extended-spectrum cephalosporin (ESC)-resistant Klebsiella pneumoniae are a problem in human patients and have been studied extensively. However, there is a pau...
Keep the bedtime story: A daily reading ritual improves empathy and creativity in children
Creativity and empathy are interconnected skills that have shown concerning declines in young people, yet both can be enhanced through practice-based interventions. We examined whether a two-week nigh...
Effect of returning home on university student hunger during South African COVID-19 lockdown
The COVID-19 pandemic exacerbated hunger levels in South Africa, with an increase from 10% pre-pandemic to 23% during the pandemic. Pre-pandemic national and global research identified university stud...
Assessment of the integrity of real-time electronic health record data used in clinical research
Background Near real-time electronic health record (EHR) data offers significant potential for secondary use in research, operations, and clinical care, yet challenges remain in en...
LIMPACAT: Multi-omics attention transformer for immune prediction in liver cancer using whole-slide imaging
Characterizing the tumor immune microenvironment from histopathological images offers opportunities for ex vivo immune profiling and prognostic assessment. However, the TCGA-LIHC dataset lacks direct...
Upregulation of angiotensin-(1–7) formation in human podocytes – enzyme activity assay upon fluid flow shear stress
The renin-angiotensin system is known for its role in renal physiology by regulating renal hemodynamics and natriuresis. Overactivation of this system exerts pathological effects in the kidney, primar...
Establishment of an amino acid metabolism related signature for prognostic and therapeutic sensitivity prediction in breast cancer by machine learning
Amino acid metabolism plays a critical role in tumor growth and immune regulation, yet its comprehensive function in breast cancer remains underexplored. We developed an amino acid metabolism–related...
Prevalence and predictors of PTSD and low resilience symptoms among subscribers of the MoreGoodDays supportive text messaging program: A cross-sectional study
Background Post-traumatic stress disorder (PTSD) is not uncommon among adolescents and young adults, with increased incidence after experiencing a traumatic event. MoreGoodDays, a...
Research on similarity test design and characteristic verification for tank fires under environmental wind conditions
Petroleum is recognized as a crucial strategic material for national sustainable development, and its safe storage, transportation, and utilization have significant impacts on the human ecological env...
Influence mechanism exploration and machine learning prediction of loess compression deformation coefficient under multi-factor coupling effects
Accurate prediction of the compression deformation coefficient of loess fillers is key for stability assessment of loess subgrade engineering. In this study, the effects of key influencing factors suc...
Impact of glucose-to-lymphocyte ratio on mortality in patients with pneumonia: A retrospective cohort study based on MIMIC-IV and eICU-CRD
Background This study aimed to explore the nonlinear positive correlation between the glucose-to-lymphocyte ratio (GLR) and increased risk of in-hospital mortality and ICU mortalit...
Bioaugmentation with native Bacillus strains enhance nitrate and nitrite removal and reshape microbiomes in low-salinity shrimp cultures: Elucidating genetic mechanisms
The intensification of shrimp farming contributes to the accumulation of toxic nitrogen compounds, which in turn affect productivity and complicates water quality management, especially under conditio...
Machine translationese of large language models: Dependency triplets, text classification, and SHAP analysis
This study addresses the challenge of distinguishing human translations from those generated by Large Language Models (LLMs) by utilizing dependency triplet features and evaluating 16 machine learning...
From financial lock-in to resilience reconstruction: Climate risk, internal capital markets and organizational resilience of high-carbon enterprises
Amid the accelerating global decarbonization, the mechanisms through which climate risk erodes the organizational resilience of high-carbon enterprises remain underexplored. Drawing on the financial l...
Exploring the relationships between the gut microbiome composition and movement patterns of laying hens in a multitier cage-free housing system
In this study we investigated the relation between caecal microbiota composition and movement patterns in laying hens. We used hens from Pure line matings of Hendrix Genetics to continuously monitor t...
Community management: An effective model to reduce medication discontinuation rate in patients with schizophrenia
Background Medication discontinuation is highly prevalent among patients with schizophrenia and is associated with poor clinical outcomes. Although community-based management model...
Phytochemical characterization, total phenolic and flavonoid content, antioxidant capacity, enzymatic profiling, and cytotoxicity of Bidens pilosa and Croton sp. from Colombia for applications in skin health
This study investigated the chemical and biological potential of Bidens pilosa and Croton sp., plants from megadiverse e...
Statin-dye conjugates for selective targeting of KRAS mutant cancer cells
Over 90% of pancreatic ductal adenocarcinoma (PDAC) patients involve KRAS mutations ( KRAS MUT ), fo...
Temperature dependence laser-assist scattering and its impact on efficiency of PEMFC
Proton Exchange Membrane Fuel Cells (PEMFCs) is one of the best promising clean technologies in future. Numerous research activities are going on regarding to stability and thermal management of PEMFC...
Fecal butyrate and deoxycholic acid quantitation for rapid assessment of the gut microbiome
The intestinal microbiome is composed of myriad microbial species with impacts on host health that are mediated by the production of metabolites. While loss of bacterial species and beneficial metabol...
High frequency head impact exposure changes hippocampal sharp-wave ripple architecture
Repeated head impact in sports leads to chronic cognitive and neurobehavior deficits even in the absence of brain pathology. High-frequency head impact (HFHI) in mice causes a chronic change to the sy...
Tracing the geopolitical influences on the morphological and functional transformation in Guangdong merchant ships: Knowledge mining from the Ming and Qing maritime archives
Although the institutional history of ancient Chinese maritime trade has been extensively documented, the functional evolution of maritime vessels and their underlying drivers remains underexplored. R...
Minding the knowledge-action gap: Results from a mixed-methods study of antimicrobial use among dairy farmers in central Uganda
Antimicrobial resistance (AMR) presents a growing threat to global health and food security, accelerated by human behaviours such as suboptimal use patterns. While the negative consequences of AMR wil...
Household factors influencing cockroach infestations and helminth parasites: Insights from a rural community in Guatemala
Cockroaches are vectors of pathogens and parasites that pose public health risks, especially in developing countries with poor hygiene and inadequate infrastructure. This study aimed to identify the h...