PLoS ONE
Articles in this Issue
Evaluation of cerebrovascular reactivity using transcranial Doppler in patients with influenza
Influenza is primarily a respiratory disease but can cause a broad spectrum of complications, including those affecting the cerebrovascular system. The aim of this study was to evaluate cerebrovascula...
Myeloid Fmr1 deficiency in mice results in reduced serum cholesterol and altered bile pathway gene expression
Fragile X Syndrome (FXS) is a genetic disorder caused by increased CGG repeats in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene which encodes an RNA-binding protein that can alter mRNA proce...
A bi-objective robust optimization model for location-transportation under uncertainty with psychological costs
After an earthquake, it is often difficult to obtain accurate information on the number of casualties in the disaster area, which brings significant uncertainty to emergency rescue logistics. In addit...
Highly significant correlation between rates of adverse childhood experiences (ACE) in youth survivors of child sexual abuse (CSA) and their biological mothers
Background Adverse Childhood Experiences (ACE) have been associated with poor long-term mental health outcomes. Measuring ACE scores in youth undergoing treatment, as well as their...
“On paper it was a surgical success, but the reality was very different”: A qualitative interview study using narrated casuistry to explore patient context in specialist care
Objective Approaches such as shared decision-making emphasize effective patient-provider communication to ensure that patient preferences are integrated into clinical practice. How...
Developing a rehabilitation intervention difficulty index: A mixed-methods study using NASA-TLX and Borg RPE in a tertiary clinical setting
Background Rehabilitation difficulty varies substantially across clinical areas and intervention types, yet few brief, standardised measures exist to quantify difficulty from the t...
Self-secure feedback control based scheme for ultra-reliable and low-latency communication
Ultra-reliable and low-latency communication (URLLC) is one of the key requirements in future wireless communications. In practical URLLC scenarios, an enhanced mobile broadband (eMBB) message togethe...
The interplay of family capital and learning engagement: Mediating mechanisms in undergraduates’ intentions to take the postgraduate entrance examination
Background The phenomenon of “postgraduate examination fever” has raised concerns about the factors influencing undergraduates’ decisions to pursue graduate education. By conductin...
Assessment of helmet usage among secondary school students in urban settings: A descriptive analytical study from Karachi, Pakistan
Introduction In Pakistan, the burden of road crashes continues to escalate due to inadequate traffic law enforcement and low helmet usage. This study assesses the knowledge, attitu...
“What’s the point, when we’re already dead?” Implementation challenges of COVID-19 public policies for indigenous peoples in the Peruvian Amazon: A sequential multi-method qualitative study
Peru issued multiple COVID-19 policies for the Amazon, yet how they worked in practice for Indigenous Peoples remains under-documented. We conducted a sequential multi-method qualitative study, review...
Image generator for tabular data based on non-Euclidean metrics for CNN-based classification
Tabular data is the predominant format for statistical analysis and machine learning across domains such as finance, biomedicine, and environmental sciences. However, conventional methods often face c...
Global learning opportunities within social innovation in health (GLOWS): A modified Delphi process to identify and pilot core competencies for learning
Background Social innovation in health refers to the community-engaged process that connects health improvement and social change. The aim of this study was to develop a consensus...
Feature-enhanced iTransformer: A two-stage framework for high-accuracy long-horizon traffic flow forecasting
Accurate and reliable long-horizon traffic flow prediction is a cornerstone of modern Intelligent Transportation Systems (ITS), yet it remains challenging due to the complex, non-linear, and dynamic s...
Global burden and projections of cervical cancer attributable to unsafe sex and smoking, 1990–2034
Objectives To analyze global trends and attributable risks (smoking and unsafe sex) in disease burden of cervical cancer from 1990 to 2034, considering different sociodemographic i...
Bioactivity of Cyperus amuricus extracts against hepatocellular carcinoma and molecular docking analysis targeting the PI3K/AKT/mTOR pathway
Cyperus amuricus (Cyperaceae) has exhibited potential anticancer activity against hepatocellular carcinoma (HCC), yet its molecular mechanisms and phytoconstituent interactions wit...
Evaluating the clinical care, quality of life and overall experiences of patients with primary biliary cholangitis (PBC) during the pandemic: A Canadian mixed-methods study
Pandemic restrictions impacted healthcare, particularly during the first year. We evaluated the impact of the pandemic on quality of life and clinical care among patients with primary biliary cholangi...
“It doesn’t require blood!”: Perceptions around non-invasive malaria testing tools in Indonesia, Peru, and Rwanda
Malaria remains a major global health challenge. Prompt, accurate diagnosis is crucial for effective case management. Current diagnostic approaches rely on invasive or minimally invasive sampling via...
Relationship between landslide susceptibility and social lag in Mexico City: The case of the west periphery
Landslides threaten sustainable development through economic and human losses. This study integrates machine learning methods to construct susceptibility maps, including topographic-hydrological indic...
Place of death for people with dementia: A scoping review
Background Dementia is a global health concern that contributes significantly to severe health-related suffering and poses high demands on healthcare systems, patients, families, a...
Food insecurity and the use of coping strategies on multimorbidity, anxiety and depression in South African adults: A nationally representative study
Objective To assess the associations between food insecurity, coping strategies, socio-economic status and anxiety, depression and multimorbidity in South Africa....
Machine learning analysis based on deep learning for fatigue diagnostics in carbon fiber reinforced polymers
Fatigue-induced degradation in Carbon Fiber Reinforced Polymer (CFRP) structures poses a critical challenge in long-term structural health monitoring (SHM) applications. In this study, a hybrid deep l...
Mechanisms of cellular senescence combined with molecular docking strategies: A biomarker study of potential therapeutic targets for allergic rhinitis
Objective Bioinformatics and molecular docking methods were used to screen potential biomarkers of cellular senescence in allergic rhinitis (Allergic rhinitis AR), which provided a...
Association between event-related disclosure and posttraumatic growth: Targeting Japanese people, measuring attitudes toward disclosure, and examining event-related rumination as a mediating variable
This study examined the association between event-related disclosure and posttraumatic growth (PTG). Specifically, it targeted the Japanese adult, assessed attitudes toward event-related disclosure, a...
Negative life events and the risk of depression: Findings from Indonesia Family Life Survey 2014/2015
Background Negative life experiences are well-established risk factors for mental health problems, yet evidence from low- and middle-income countries remains limited. Many studies...
Evaluation of the uncertainty in calculating nanodosimetric quantities due to the use of different interaction cross sections in Monte Carlo track structure codes
Biological effects induced by diverse types of ionizing radiation are known to show important variations. Nanodosimetry is suitable for studying the link between these variations and the patterns of r...