PLoS ONE
Articles in this Issue
Continuous wound infiltration versus placebo following elective minimally invasive colorectal surgery (CIMICS): study protocol for a randomised controlled trial
Background Enhanced Recovery After Surgery (ERAS) programs emphasize multimodal analgesia to minimize opioid use and improve patient outcomes. Continuous wound infiltration (CWI) w...
Ancient use and long-distance transport of the Four Corners Potato (Solanum jamesii) across the Colorado Plateau: Implications for early stages of domestication
Despite its long history, utilitarian value, and cultural significance to several Indigenous Tribes in the Southwest USA, the extent to which the Four Corners potato ( Solanum jame...
Comparison of self-reported survey and wastewater-based epidemiology measures of cocaine use on a college campus
Background Wastewater–based epidemiology (WBE) has the potential to produce reliable, efficient, and non-invasive measures of current psychoactive drug use. The aim of this study w...
Identification of hypoxia- and mitophagy-related diagnostic biomarkers for ulcerative colitis based on bioinformatic analysis and machine learning
Background Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease of unknown etiology that is associated with a significant risk of progression to colorectal c...
Paleo-proteomic analysis of Iron Age dental calculus provides direct evidence of Scythian reliance on ruminant dairy
The Scythians, often described as mounted horse-back warriors of the Iron Age steppe with lavish burial goods, have attracted increasing scientific interest over the past years. Recent genetic and mul...
How can we reduce the rate of Violent-Sexual Crimes? An attempt at street design
Well-designed streets can foster a harmonious social environment. Street crime rates are closely related to street design, and Violent-Sexual Crime (VSC) is a significant public order concern. While m...
Optimizing regional innovation ecosystems through actor-environment coevolution: A dynamic configurational analysis from a CAS perspective
The interaction among innovation actors and environmental uncertainties has intensified the complexity of the evolution and drivers of regional innovation ecosystems, with profound implications for re...
Effect of fluoxetine on organ dysfunction and mortality in severe sepsis
Introduction Sepsis is a leading cause of morbidity and mortality in intensive care units, characterized by a dysregulated host response to infection. Recent evidence suggests fluo...
Immortalization and characterization of Schwann cell lines derived from NF1-associated cutaneous neurofibromas
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition in which patients are heterozygous for a disruptive pathogenic variant in the NF1 gene. The mo...
The impact of mobile internet usage patterns on employment intentions of medical students: A cross-sectional study
Background China’s healthcare system is undergoing major transformations, with urbanization worsening the unequal distribution of medical resources and primary healthcare instituti...
Improving the measurement resolution in BOTDR sensor with optimized wavelet denoising strategy
Signal averaging imposes a significant trade-off between measurement time and measurand resolution in a sub-meter differential cross-spectrum Brillouin optical time domain reflectometry (DCS-BOTDR). T...
RIPK2 induces docetaxel resistance in prostate cancer through the NF-κB/P-gp signaling pathway
Chemoresistance is a reason for treatment failure in prostate cancer. Receptor-interacting protein kinase 2 (RIPK2) has been shown to play a role in drug resistance in various cancers; however, its ro...
Retraction: Impact of miR-223-3p and miR-2909 on inflammatory factors IL-6, IL-1ß, and TNF-α, and the TLR4/TLR2/NF-κB/STAT3 signaling pathway induced by lipopolysaccharide in human adipose stem cells
An open-source closed-loop Virtual Reality system to investigate social interactions and collective behavior in fish
This study introduces a low-cost, open-source, immersive Virtual Reality (VR) system designed to investigate real-time social interactions and collective behaviors in fish. Understanding collective an...
Text-to-image generation with enhanced GANs: Bridging semantic gaps using RNN and CNN
Text-to-image generation is the process of generating images from a given text description. It is the most challenging task to produce consistently realistic images according to our conditions. We hav...
Cognitive functioning in context: Leisure activity engagement, social capital, and urbanicity-rurality interplay
Leisure activity associations with cognition may operate differently depending on an individual’s context. We evaluated whether activity-cognition associations were influenced by community and geograp...
Effect of sodium hydroxide dosage on strength development in cement-fly ash mortars: Experimental and ANN-based prediction
Fly ash, a by product from coal and biomass combustion in fossil-fuel power plants, is composed of fine particulate matter that can contribute to terrestrial and atmospheric pollution if not properly...
DFENet: A diverse feature extraction neural network for improving automatic modulation classification accuracy in wireless communication systems
In this paper, a convolutional neural network (CNN) model, named DFENet, is composed of multi-branch blocks for diverse feature extraction (DFE) to improve the accuracy of automatic modulation classif...
Variability in sodium content of takeaway foods: Implications for public health and nutrition policy
Background: Excessive sodium intake is a major modifiable risk factor for cardiovascular disease, yet accurately assessing dietary sodium remains challenging due to food compositio...
A deep learning-based model for automatic identification of mesopelagic organisms from in-trawl cameras
Mesopelagic organisms play an important role in the ocean’s carbon transport and food webs and have been regarded as a potential harvestable resource. Their extensive aggregations in the upper thousan...
Community-level externalities in child health: Evidence from Sub-Saharan Africa
We use data from twenty countries from the harmonized versions of the Demographic and Health Surveys (DHS) for countries in Sub-Saharan Africa to investigate the extent to which contextual factors suc...
Extraction of anthocyanins from jambolan fruit using ethanol and deep eutectic solvents: Bioactivity, cytotoxicity, and application as a natural colorant
This study aimed to evaluate the extraction of anthocyanins from jambolan ( Syzygium cumini ) fruit using choline chloride-based deep eutectic solvents (DESs) a...
Intelligent diagnosis method for river and lake ecosystem health based on improved slime mold algorithm-optimized SVR
In the diagnosis of river and lake ecosystems, there are complex nonlinear relationships among water quality parameters, and their dynamic change mechanisms are rather complicated. Traditional statist...
Cerebral microbleed patterns and the risk of incident dementia in elderly adults: The ARIC study
Objective The association between cerebral microbleeds (CMBs), an indicator of microvascular damage on MRI, and incident dementia (ID) remains inconclusive. We aim to investigate t...
Effects of intermittent hypoxia on adipose-derived mesenchymal stem cells in protecting alveolar type II cells from injury
Adipose-derived mesenchymal stem cells (ADSCs) have demonstrated significant therapeutic effects on acute lung injury. Numerous studies have reported that preconditioning ADSCs can enhance their thera...