PLoS ONE
Articles in this Issue
The shared biomarkers and molecular mechanisms of systemic lupus erythematosus and type 2 diabetes
Systemic lupus erythematosus (SLE) and type 2 diabetes mellitus (T2DM) share inflammatory and metabolic disturbances, yet the molecular mechanism of their overlap remains unclear. This study used inte...
Direct measurement of free glucocorticoids in small volumes of mouse and rat serum using ultrafiltration and liquid chromatography-tandem mass spectrometry
Glucocorticoids are critical steroid hormones secreted from the adrenal glands. In mice and rats, over 90% of circulating corticosterone is bound to proteins such as corticosteroid-binding globulin an...
Physical exercise and academic performance among students in the medical field at Jordanian Universities
Background The literature emphasizes multiple factors that affect academic performance, including emotional and physical well-being, motivation, and physical exercise. University s...
Stratifying cardiometabolic risk in urban Chinese children with obesity: Study protocol of the Shenzhen Children Cohort Study (SCCS)
Background Cardiovascular risk factors often begin in early childhood, with obesity being a major contributor. However, not all children with obesity share the same risk profile. T...
The mechanism of mammalian peroxidase destruction of invasive microbes
We calculated the internal energies (ΔE) for the breakdowns of HOI, HOBr and HOCl for the first time using the principles of molecular orbital theory. The release of atomic oxygen (ATOX) from all thre...
Allostatic load in thyroid cancer is higher than that of other cancers: A secondary analysis using NHANES
Background To compare the levels of allostatic load score (ALS) between thyroid cancer patients and patients with other types of cancer and explore whether ALS mediates the associa...
A cost-effectiveness analysis comparing pembrolizumab combined with chemotherapy versus chemotherapy alone for advanced biliary tract cancer: US and China perspectives
Objective In the KEYNOTE-966 study, the clinical benefits of pembrolizumab plus chemotherapy were demonstrated for patients with advanced biliary tract cancer (BTC). At this point,...
Uptake of cervical cancer screening and its associated factors among women of reproductive age in Kericho County
Cervical cancer is a public health issue among reproductive-aged women worldwide. It is the second most common cancer among females and contributes to 12.9% of new cancer cases and 11.84% of all cance...
Optimizing expanded carrier screening for China: Multi-center study establishes 202-gene panel with optimal cost-effectiveness in preconception and prenatal care
Objective To evaluate the cost-effectiveness of different expanded carrier screening (ECS) panels for couples in China during preconception and early pregnan...
Correction: Who gets what, where: To what extent are inequalities in distribution of Norwegian child welfare service measures related to spatial and temporal variation
Retraction: Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells
Multiple causal pathways of high-quality development for semiconductor enterprises in China
As China’s economy undergoes transformation, enhancing the high-quality development of semiconductor enterprises has profound implications for overall economic growth. This study constructs a multi-fa...
The sustainability of recreational sports in Chinese cities based on cognitive entropy
With progress of science and development of economy, increasing numbers of urban residents take part in recreational sports (RS) due to their more leisure time and increased income. The RS is defined...
Determinants of outpatient service use among Orang Asli in Malaysia using Andersen’s Behavioural Model
Background Indigenous populations, including the Orang Asli in Malaysia, experience persistent health disparities due to historical, socioeconomic, geographic, and cultural barrier...
Explainable depth-wise and channel-wise fusion models for multi-class skin lesion classification
The clinical adoption of deep learning in dermatology requires models that are not only highly accurate but also transparent and trustworthy. To address this dual challenge, this study presents a syst...
Impact of coexisting diabetes on the development of cardiovascular disease and death in patients with cancer
Diabetes is a risk factor for the development of cardiovascular disease (CVD); however, its effects on the incidence of CVD and survival in patients with cancer without CVD at the time of cancer diagn...
The effects of iTBS to cerebellar vermis on balance function in frail older people: A protocol for a randomized controlled trial
Background With the gradual deepening of the aging of the population, the closely related problem of frailty in older people is becoming increasingly prominent. Frailty can increas...
Impact of COVID-19 on new pharmacotherapy for insomnia: A matched cohort study using the national insurance claims database in Japan
Background The COVID-19 pandemic has profoundly affected impacted both physical and mental well-being. This matched cohort study investigated the effects of COVID-19 on pharmacolog...
Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis
This study investigates the protective effects of nicotinamide mononucleotide (NMN) against aluminum-induced testicular dysfunction in mice. While previous research has demonstrated the general protec...
Variation in public hospital costs for children and young patients from priority populations: An Australian health service economic analysis
The extent to which inpatient hospital costs for children and young patients (CYP) from the priority population in Australia differ from their peers is unknown. Using a multivariate analysis approach,...
Piperine inhibits biofilm formation and efflux activity and dysregulates lipid metabolism in Mycobacterium abscessus
The nontuberculous Mycobacterium abscessus is a human pathogen that causes chronic lung infections and soft tissue infections. The bacterium forms biofilms and...
Gender-inclusive sexual health literacy scale for sex workers (SHL-SW): Development and validation in Thailand
Background Marginalized sex workers worldwide face persistent sexual health inequities, yet lack a validated, gender-inclusive tool to measure their sexual health literacy (SHL). T...
Evolutional law and elastoplastic constitutive model of structural loess considering moisture contents
The deformation properties of natural undisturbed loess are intricately linked to its structural qualities. Structural characteristics can markedly improve soil stability, allowing structured loess to...
Performance of DeepSeek and ChatGPT on the Chinese Health Professional and Technical Examination: A comparative study
Background Large language models (LLMs) are increasingly applied in medical education, yet their reliability in specialized, high-stakes assessments such as the Chinese Health Prof...
A screening strategy based on machine learning for diagnostic biomarkers in small cell lung cancer
Small cell lung cancer (SCLC) is the most aggressive subtype with high mortality rates due to the lack of specific diagnostic biomarkers to delay the optimal opportunity for treatment. Traditional bio...