PLoS ONE
Articles in this Issue
Clinical proof of concept for small molecule mediated inhibition of IL-17 in psoriasis
Efficacious and well-tolerated systemic, oral treatments for psoriasis are needed. We report preclinical and phase 1c (NCT06808815) results for DC-806, a small molecule interleukin (IL)-17 inhibitor,...
Examining the role of social factors in the utilization of preventive cardiovascular clinical services: An analysis using Andersen’s behavioral health model
Background Cardiovascular disease (CVD) remains the leading cause of mortality in Saudi Arabia, mainly influenced by multiple lifestyle risk factors. Addressing this challenge requ...
Turning crisis into potential: Leveraging the skills of forced Ukrainian migrant women in Poland
The 2022 Russian invasion of Ukraine triggered a large influx of highly skilled Ukrainian women into Poland, presenting both challenges and opportunities for their effective economic integration. This...
Real-world study: Assessing the impact of hemolysis on 48 biochemical and immunological analytes through big data analysis and its feasibility validation
Background This research utilizes clinical laboratory real-world data to explore the influence of in vitro hemolysis on 48 biochemical and immunological analytes, aiming to propose...
Intuitive or deliberative dishonesty: The effect of abstract versus concrete victim
There has been ongoing debate over whether people are intuitively honest or intuitively dishonest. A recent social harm account was proposed to address this debate: dishonesty is intuitive when cheati...
Formic acid-sulfide synergistic aging kinetics and nanometer titanium dioxide modification mechanism in oil-immersed transformer insulation system
This study investigates the synergistic aging effects of formic acid and sulfides on oil-immersed transformer insulation systems and explores the mitigating role of titanium dioxide (TiO₂) nanoparticl...
Attitude toward physical activity after total hip or knee replacement: A cross-sectional survey study of Dutch and Norwegian patients
Objective To gain insight into the attitude towards physical activity (PA) of Norwegian and Dutch patients after hip or knee replacement, possible differences in attitude between t...
Neighborhood collective efficacy and children and adolescents’ externalizing behaviors across development: A systematic review
Objective To synthesize and describe the relationship between neighborhood collective efficacy (NCE) and children and adolescents’ externalizing behaviors to inform practice and po...
The role of obesity and Type 2 diabetes in lung health: A systematic review (2024)
Introduction Type 2 diabetes is associated with mild airways restriction, yet obstructive lung conditions are prevalent in people with diabetes. Obesity is a confounding factor and...
Evaluation of rat pancreatic islets damage after siRNA microporation
Small interfering RNA (siRNA) can be used for the temporary inhibition of gene expression, and one possible delivery method is microporation. In this study, we evaluated whether microporation is a sui...
Revisiting the excess volatility puzzle through the lens of the Chiarella model
We amend and extend the Chiarella model of financial markets to deal with arbitrary drift in long-term value in a consistent way. This allows us to improve upon existing calibration schemes, opening t...
Embedding trauma-informed, culturally sensitive, and compassionate care training in health and social care curricula: Evaluation of a multidisciplinary student intervention utilizing a pre- post-test survey design
Introduction There were an estimated 281 million international migrants across the globe in 2020. Additionally, 30.5% of people globally have been exposed to four or more traumatic...
Pharmacokinetics of Dolutegravir, nucleoside analogues, and intracellular metabolites using plasma separation cards: A comparative analysis with traditional sampling methods in healthy volunteers
Objectives Adherence to antiretroviral therapy is essential for achieving viral suppression. Plasma separation cards (HemaSep; HS-DBS) provide advantages for pharmacokinetic (PK) a...
Wearable devices and ecological momentary assessment EMA in the workplace: A study protocol on work stress assessment
Work-related stress (WRS) remains a significant concern in occupational health. Despite its significance, measuring WRS presents methodological challenges. Advancements in real-time data collection me...
Linear convergence of the NQZ algorithm for finding the H-spectral radius of nonnegative tensors
The R -linear convergence of the NQZ algorithm for computing the H -spectral radius of a class of weakly irreducible non...
Developing count regression techniques for predicting the number of new type 2 diabetes cases in Saudi Arabia
Type 2 diabetes (T2D) is a chronic condition affecting millions globally. A robust predictive model to estimate the number of new cases of T2D can facilitate precise monitoring and effective intervent...
HbA1c underperforms in identifying abnormal glucose tolerance in the presence of G6PD deficiency: Insight from the Africans in America study
G6PD deficiency (G6PD-D) variants are associated with lower hemoglobin A1c (HbA1c) concentrations, raising concerns about the diagnostic efficacy of HbA1c for abnormal glucose tolerance (Abnl-GT) in A...
Effect of luting materials and root third on glass fiber posts bonding strength after hydrothermal aging
Statement of the problem Teeth with extensive coronal destruction face the challenge of retaining the restorative materials; however, glass fiber posts cemented with resin material...
Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial
Objective Postoperative pain is the most notable issue after cesarean section (CS). The contributing factors include hyperalgesia, anxiety, depression, sleep disorders, and inflamm...
Transcriptional regulator NtrC modulates nitrogen assimilation, virulence, and the extracellular glutamine synthetase activity in Acinetobacter baumannii
Acinetobacter baumannii is a growing threat characterized by worrisome antibiotic resistance. A deeper understanding of its resistance and virulence mechanisms is essential for dev...
Investigating spatial distribution of kindergartens in Chinese cities: A spatial stratified heterogeneity approach
The spatial equity of kindergarten distribution is a critical concern for China’s educational policy. This study investigates the socioeconomic determinants underlying the spatial stratification of ki...
Intestinal decontamination with rifaximin attenuates LSEC dysfunction and liver fibrosis in mice
Background The gut microbiome plays a pivotal role in the development and progression of liver disease. Liver sinusoidal endothelial cells (LSECs), as the first hepatic barrier exp...
Fluid shear stress-dependent modulation of the basal endothelial glycocalyx
The vascular endothelial glycocalyx is a major regulator of endothelium function, serving as a vital mechanotransducer and barrier. Shear stress due to blood flow exerted on the apical endothelial cel...
Stool and vaginal microbiome profiles patterns among Black and White endometrial cancer survivors: A pilot study in North Carolina
Background Endometrial cancer is the most common gynecologic cancer in the US. Endometrial cancer survivors may experience changes in microbiome due to cance...
Evaluation of Pseudomonas fluorescens for biocontrol of early blight (Alternaria solani) in tomato in North Wollo, Ethiopia
Tomato (Solanum lycopersicum) is a widely used vegetable in Ethiopia, but its production is severely affected by late blight, early blight and bacterial wilt. This study aims to isolate Pseudomonas fl...