PLoS ONE
Articles in this Issue
Motivation and determinants of research careers among physicians: Exploring pros and cons of the Dutch MD-PhD model
Introduction Training pathways, such as MD-PhD-programs, have been established to increase the physician-scientist workforce. Still, MD-PhDs represent only a small fraction of the...
Correction: Distinct Distal Gut Microbiome Diversity and Composition in Healthy Children from Bangladesh and the United States
Maternal hyperuricemia and adverse neonatal outcomes in normotensive pregnancies: Evidence from a prospective cohort study in Eastern Uganda
Background Maternal hyperuricemia is a potential biomarker of adverse pregnancy outcomes, but evidence among normotensive women in low- and middle-income countries is limited. We a...
Social inequities and clinical outcomes in young women with cervical cancer: Real-world evidence
Objective To assess the influence of social inequities and clinicopathological factors on survival outcomes in young women with cervical cancer treated at a comprehensive public ca...
Revealing undergraduate biology students’ conception of variability and error bars within graphing
Creating and interpreting graphs are quantitative reasoning skills all science, technology, engineering, and math students need to develop. In biology, data are lacking in our understanding of how und...
Effects of fibroblast growth factor 2 on muscle precursor cells from mouse limb and extraocular muscle
Fibroblast growth factor 2 (FGF2) is known to play a role in skeletal muscle development and growth. We examined two populations of myogenic precursor cells for their responses to FGF2...
Association of hand grip strength with rheumatoid arthritis and osteoarthritis in the Korean population: A large-scale cross-sectional study
Background Low hand grip strength (HGS) is associated with osteoarthritis (OA) and rheumatoid arthritis (RA), but no studies have simultaneously examined the associations of OA/RA...
Detecting the body’s reproductive hormonal brake against tissue overgrowth: Micrin/SgII-70
A new humoral factor has been detected, within a project aiming to disclose the body’s reproductive hormonal brake against tissue overgrowth, micrin (‘my-crin’). Factor purification involved fractiona...
Enhanced soil attributes, yield and fruit quality of Medjool date palm (Phoenix dactylifera L.) in response to filter mud/cake for drylands sustainability
Soils of drylands in arid and semiarid conditions need developing approaches to improve the holding capacity of water and nutrients to avoid desertification. In this study, we examine the characterist...
Glucose dysregulation in hospitalized non-critically ill patients with a suspected infection: A prospective study using continuous glucose monitoring
Introduction Dysglycaemia, defined as hypo- or hyperglycaemia, can occur during infection and is associated with worse outcomes during hospitalization. Previous studies on dysglyca...
Protocol for a qualitative study exploring older adults’ experience of mental health and wellbeing in work-related later life transitions in the UK
Later life transitions occur in the later years of life and can cause significant disruption to a person’s usual daily routine and lifestyle. Transitions that are specifically related to work, such as...
Exploring the association between indoor air pollution (IAP) and anaemia among pregnant women in India
Background Anaemia during pregnancy in India persists despite policy attention and nutritional interventions. While its primary determinants are well-recognized, the association be...
Mountain moves: Spatial interaction modelling of Bulgaria’s internal migration (1934-1992)
Bulgaria experienced dramatic rural decline alongside rapid urban growth during the 20th century, shaped by both demographic pressures and socioeconomic change. Today, it remains one of Europe’s faste...
A framework for subjective motion production: A construal approach with Mandarin evidence
This study develops and validates an experimental framework for investigating the production of subjective motion sentences (e.g., The road winds through the valley...
Constitutive activation of TGF-β receptor type I promotes cortical and cancellous bone formation in adult mice
Transforming growth factor β (TGF-β) is a pluripotent cytokine that plays a pivotal role in regulating bone remodeling. In this study, we investigated the skeletal phenotype of 24-week-old transgenic...
Visual perturbation training to reduce visual dependency in Parkinson’s disease: A randomized controlled trial
Introduction Decreased gait automaticity and increased visual dependency are important contributors to falls in people with Parkinson’s disease. The aim of this study was to assess...
Resistivity method-based rock core orientation experimental protocol
Restoring core orientation is critical for subsurface characterization but remains challenging as over 99% of cores are obtained through conventional drilling. We propose a novel, non-destructive meth...
Enzymatic hydrolysis of starch from the anthocyanin extraction residue (AER-starch) with ultrasound pretreatment: A techno-economic assessment
Purple yam ( Dioscorea alata ) is a tropical tuber crop that is a source of anthocyanins and starch. Starch can be isolated from the large quantity of extractio...
Research on the management of the system construction of National parks with China characteristics: Evidence from policy texts
Quantitative evaluation of China’s national park policy texts is an important window to understand its national park governance logic, top-level design of ecological protection, and future practice. T...
Factors associated with survival after pediatric in-hospital cardiac arrest: A national database analysis 2015–2022
Background Pediatric in-hospital cardiac arrest (IHCA) is frequently fatal, and evidence from middle-income settings needed to guide quality improvement is sparse. We used nationwi...
Gestational diabetes–Risk factors and outcomes among American Samoan Women (GROW): A longitudinal cohort study protocol
Background Gestational diabetes mellitus (GDM) is linked with adverse health outcomes for both mother and infant and increases the risk of type 2 diabetes me...
Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics
Polyglutamylation, a post-translational modification (PTM) catalyzed by a subset of Tubulin Tyrosine Ligase-Like (TTLL) family enzymes, regulates microtubule dynamics through its influence on interact...
Correction: The impact of internet use in the digital era on public political trust in China—An empirical study based on CGSS 2021 data
Access to information in deaf and hard-of-hearing people
Deaf and Hard of Hearing (HoH) people often face communication barriers that limit their access to crucial information. This study investigates which modalities deaf people used to gather information...
Unintended evolutionary consequences of a minimum landing size regulations: Evidence and implications of fisheries-induced evolution
A total of 725 historical photographs taken between 1940–2022 were analysed to assess the temporal variations in target species and the size-frequency distribution of recreational fishing catches in t...