PLoS ONE
Articles in this Issue
Editorial Note: Small object detection algorithm incorporating swin transformer for tea buds
Integrated transcriptome and single-cell sequencing analysis identify blood-pancreas shared lncRNA biomarkers in new-onset T2DM
Type 2 diabetes mellitus (T2DM) is characterized by β-cell dysfunction and insulin resistance, yet the early molecular drivers remain elusive. This study set out with the aim of identifying blood-panc...
Using core components in process evaluation: Passport skills for life
Although school-based SEL programmes show robust effects in controlled studies, their real-world impact varies due to inconsistent implementation. Core components (CCs), the essential theory or eviden...
Molecular evidence of recent hybridization between eastern and western populations of a whitefly species on cassava in the Democratic Republic of the Congo: A potential threat to the spread of cassava brown streak disease
Cassava mosaic disease (CMD) and cassava brown streak disease (CBSD) are two viral diseases that threaten cassava production in the East and Central African countries. These diseases are spread by mem...
Salidroside protects against high-altitude hypoxia-induced kidney injury via regulation of renal dopamine D1-like receptors
High-altitude hypoxia is a well-established risk factor for acute kidney injury (AKI), yet effective therapeutic options remain scarce. Salidroside, the primary active compound extracted from Rhodiola...
Exploring synchronous, asynchronous, and conventional online courses in higher education
Online learning has expanded substantially in recent years, yet comparatively little is known about how different online modalities influence learners’ perceptions and their intention to continue lear...
BAAR: A framework for blockchain-based anonymous and revocable user authentication scheme
Blockchain-based systems increasingly require authentication mechanisms that simultaneously preserve user privacy, support accountability, and enable efficient credential revocation. However, most exi...
Chloroplast genome assembly, annotation, comparative genomics, and genetic diversity analysis of a vulnerable endemic species Lavandula maroccana Murb
Lavandula maroccana Murb., an endemic species of the western Mediterranean, is classified as vulnerable and was added to the International Union for Conservation of Nature (IUCN) R...
The impact of a non-functioning pituitary adenoma on life – A qualitative study of patients’ experiences
Purpose Most studies regarding quality of life in patients with non-functioning pituitary adenoma are based on general questionnaires that might not capture disease-specific aspect...
Real-time vectorcardiography simulator system
Vectorcardiography provides a spatial orientation and magnitude of the electrical activity of the heart, but its complexity and lack of interactive resources have limited its application in medical an...
Barriers and facilitators in physical activity among youth with cerebral palsy in Sweden: A qualitative study
Limitations to full social participation in physical activity—both during leisure time and in physical education—persist among young individuals with cerebral palsy. This study explores the experience...
Telemedicine for rotator cuff syndrome: Asynchronous exercise and remote follow-up in a randomized controlled study
Introduction Rotator cuff syndrome (RCS) is a common musculoskeletal condition that requires rehabilitation. Telemedicine involving asynchronous exercise video and remote follow-up...
Comprehensive protocol for mixed reality visualization and navigation using 3D Slicer
Advancements in mixed reality (MxR) technology have significantly enhanced neurosurgical navigation by improving visualization, spatial accuracy, and surgical outcomes. MxR navigation (MRN) provides a...
A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis
Psoriasis vulgaris is a common chronic inflammatory skin disease associated with hyperproliferation and defective differentiation of keratinocytes. Despite new effective treatments using biologicals t...
Biobanking of gynecologic cancer biospecimens: Development, quality control, and translational applications
Introduction This study presents a nationwide infrastructure for the collection and utilization of gynecologic cancer biospecimens, established through the Korea Biobank Project. W...
Emotion recognition based on feature weight analysis of multiple physiological signals
Emotion recognition stands as a complex and prominent challenge within contemporary artificial intelligence research. Deep learning on physiological signals has boosted emotion recognition, yet unimod...
Beyond mono fertilization: Mixed fertilization enhances productivity and quality of chili (Capsicum frutescens)
While the effects of different fertilization strategies on chili ( Capsicum frutescens ) cultivation have been previously examined, the lack of comparative asse...
Retraction: Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum
Twelve‑month rehospitalization after IBD‑related hospitalization in Germany: A retrospective cohort study using administrative hospital data
Background/Aims Rehospitalization is an important indicator of disease burden and healthcare utilization in inflammatory bowel disease (IBD), yet real-world data from Germany remai...
Developing a programme theory of a complex, home-based rehabilitation intervention for recovery after an episode of delirium
Background Delirium in older adults is associated with persistent cognitive and functional decline, increased institutionalisation, and higher mortality. Evidence-based strategies...
Quantitative optimization exploration of the cultivation program for medical product management professionals based on QFD-obstacle integration model
Objective The current research on talent cultivation programs for the emerging interdisciplinary field of medical product management in Chinese universities faces the limitation of...
Translation, cultural adaptation, and psychometric validation of the Simplified Chinese Athlete Sleep Behavior Questionnaire (ASBQ-CN) in Chinese athletes
Objective To translate, adapt, and validate the Simplified Chinese Athlete Sleep Behavior Questionnaire (ASBQ-CN) for both adolescent and adult athletes....
A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features
Genes encoding subunits of the mitochondrial tricarboxylic acid cycle enzyme complex succinate dehydrogenase (SDH) are a leading cause of the neuroendocrine tumour syndrome hereditary paraganglioma-ph...
Participation of children and adolescents in healthcare, prevention and health research: A dot survey
Background While adults are actively involved in medical decisions, this has long been neglected in the case of children and adolescents. Traditionally, parents and doctors make de...
Myo-inositol versus D-chiro-inositol in murine in vitro follicular development: An experimental study relevant to polycystic ovary syndrome
Inositol plays a crucial role in follicular development by regulating insulin signaling and ovarian function. However, its precise mechanism of action remains unclear. This study investigated the effe...