PLoS ONE
Articles in this Issue
Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling
Introduction The progression of Chronic gastritis seems to follow a pattern from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG) to cancer, so it is parti...
A novel multi objective grey wolf optimization fuzzy miner for process discovery: Incorporating robustness and explainability in model evaluation
Process mining provides methodologies for analyzing, monitoring, and improving processes based on event logs. This study introduces Fuzzy Multi-Objective Grey Wolf Optimization (Fuzzy MOGWO), which in...
Rapid invisible frequency tagging (RIFT) does not evoke intermodulation components in the neural response
The human visual system performs nonlinear integrative operations at multiple stages of visual information processing. For instance, integrating parts of visual stimuli into a coherent object involves...
Efficacy and safety of rimegepant 75 mg orally disintegrating tablet for the acute treatment of chronic rhinosinusitis in adults: Results from a multicenter, randomized, placebo-controlled, phase 2/3 trial
Calcitonin gene-related peptide (CGRP) activation could play a causal role in the pathophysiology of chronic rhinosinusitis (CRS), a long-term inflammatory disease of the nasal cavity and paranasal si...
Multi-index analysis of climate change events recorded by loess-paleosol deposits in the upper Hanjiang River valley since MIS 3
The upper Hanjiang River basin has been an important area for human life and production since ancient times. Marine Isotope Stage 3 (MIS 3) is a special period of relatively warm and humid climate dur...
Effect of home-based isometric handgrip exercise with a commercially available device on blood pressure in older adults with hypertension: A randomized controlled trial
Background Isometric handgrip exercise may help reduce blood pressure, but its effectiveness using inexpensive, home-based devices remains unclear. This study aimed to evaluate the...
Genetic variations and clinical implications of B-thalassemia in Iraqi population
β-thalassemia is a prevalent genetic disorder in Iraq, leading to significant health issues due to reduced hemoglobin production. The DNA sequencing technique was used to explore genetic variations an...
The effect of NASM-based corrective exercises on lumbar lordosis angle and selected muscle activity in women with lower cross syndrome: A randomized clinical trial
Background Lower Cross Syndrome (LCS) is a complex musculoskeletal condition characterized by muscle weakness and tightness patterns, typically resulting from prolonged and repetit...
Variation in the quality of opioid use disorder treatment in the Medicaid population in 2019
Background This study aimed to describe state- and urbanicity-stratified differences in three opioid use disorder (OUD) treatment metrics among Medicaid beneficiaries in 25 states...
Retraction: Anti-cancer effects of polyphenol-rich sugarcane extract
Acute healthcare utilization associated with positive SARS-CoV-2 testing or serology among people experiencing homelessness: A prospective cohort study
Background Current literature drastically underestimates SARS-CoV-2 infection among homeless populations, undermining our understanding of acute healthcare utilization following in...
Cost analysis of hospital-based symptomatic uterine fibroids in the kingdom of Eswatini: A prevalence-based cost-of-illness study
Background Uterine fibroids are common benign tumours of uterine smooth muscle. It has been established that uterine fibroids cause a marked global financial burden on healthcare s...
How do young children respond to the distress of others? Applying infrared thermography and behavioural analyses to examine the development of emotion contagion and empathy
Empathy is a core feature of the human social experience, underpinned by the sharing of and understanding of others’ states. However, we know relatively little about its early development. Here, we us...
Gender distribution in authorship on research submissions at the European College of Veterinary Surgeons Annual Scientific Congress: 2012–2022
The objective of this study was to explore gender distribution for authors on research presentations at European College of Veterinary Surgeons (ECVS) Annual Scientific Meetings from 2012–2022. Our po...
Strengthening laboratory management towards accreditation in Tanzania: The 13 years of remarkable revolutions in laboratory quality management system
Introduction The increase in demand of laboratory services and recent advancements in laboratory technologies underscore the importance of quality laboratory services in delivering...
Shifting from an expected to an opportunistic pathogen: Comparison of cases of infant late and very late onset group B streptococcal (GBS) infection in a Canadian city over a 27-year period
Background Despite decades of study, the characteristics of infants with invasive group B streptococcus (GBS) late onset disease (LOD) (onset day 7–89 of life) and in particular ve...
A comprehensive economic assessment of the burden of obesity in Kuwait
Background Obesity is a complex public health issue that has risen to epidemic proportions globally. The aim of this study was to estimate the economic costs associated with obesit...
Pairing taguchi based design of experiment with response surface methodology for diesel engine performance optimization using biodiesel-magnesium oxide nanoparticles blends
The increasing demand for diesel engines in agriculture, transportation and power generation has led to the overconsumption of fossil fuels, demanding the search for sustainable alternatives. Biodiese...
Nutrition-related knowledge, attitudes, practice, and mental health status of people living with HIV in Dubai, United Arab Emirates: A cross-sectional descriptive study
Background Despite significant advancements in management, Human Immunodeficiency Virus (HIV) infection remains a global health concern. Limited research exists on the nutrition-re...
Pre-analytical errors in a high-volume Bangladeshi diagnostic centre: Prevalence, workload impact, and mitigation strategies
Background Pre-analytical errors are the most frequent cause of laboratory mistakes, accounting for nearly half of all diagnostic inaccuracies worldwide. These errors can invalidat...
Near Neutral Selectionist Theories (NNST) for SARS-CoV-2 suggested by the substitution-mutation ratio (c/µ) analysis
A definitive test to measure genome-wide fitness effects of any nucleotide mutation, including translated regions ( TRs ) and untranslated regions (...
Social media analysis reflects the negative sentiments experienced at both time changes with somewhat more depressive impact in early fall
We quantify the effect of biannual time changes on sentiment using US online and social media posts from periods around changes to Daylight Saving Time (DST) in the spring and Standard Time (ST) in th...
Tailored job coaching for people with severe mental illness living in supported housing settings: A realist approach
Background For people with severe mental illness (SMI) residing in supported housing settings, finding and maintaining paid or unpaid work is challenging. This study was initiated...
Impact of demographic factors and HIV status on Hepatitis B vaccination adherence and completion rate among high-risk populations in Lagos State, Nigeria
Hepatitis-B-Virus (HBV) remains an important global public health concern, as well as a primary cause of both acute and chronic liver diseases, with over 18 million people infected by the virus in Nig...
Beyond Ubiquity: Scale-dependent patterns of tardigrade diversity on the Iztaccíhuatl volcano
The diversity of tardigrade communities has been related with variables, such as habitat type, litter type, elevation, among others. However, the integration of variables in a multiscale context has b...