PLoS ONE
Articles in this Issue
Analysis of ovarian cancer immune cell profile identifies immunosuppressive states associated with adverse clinical attributes and survival times
The ovarian tumor microenvironment (TME) is highly immunosuppressive, limiting immunotherapy effectiveness. We investigated whether the composition, ratios, and polarization of infiltrating immune cel...
Insecticidal and knockdown resistance status of Anopheles gambiae s.l (Diptera: Culicidae) to pyrethroid and organophosphate insecticides in Osun State, Nigeria
Insecticide resistance in malaria vectors remains a global public health problem; however, little is known about resistance levels in Osun State, despite relatively high rates of malaria and distribut...
Evaluation of AT121 versus morphine on cortical neurons electrophysiology and dopamine concentrations in hippocampal cells
In order to achieve pain relief without associated tolerance and dependence risks of general opioids like morphine, researchers have designed AT121 as potent safe alternative. In this study, we evalua...
Experiential learning to advocacy: A peer-led approach to safe medication disposal in pharmacy education
Introduction Safe medication disposal is crucial for public health and environmental sustainability, yet public awareness remains limited. While educational campaigns exist, pharma...
Association of polycythemia with outcomes of acute decompensated heart failure: A matched and weighted cohort analysis
Aims The prognostic significance of polycythemia in acute decompensated heart failure (ADHF) is unclear. This study aimed to evaluate the clinical profile and prognostic implicatio...
Vaccination scenario-based study on seasonal influenza in Republic of Korea
Background Seasonal influenza presents a persistent threat to global health, with the elderly (65 + years) facing disproportionate risks of severe clinical outcomes. While the Worl...
A cross-dataset harmonized intrusion detection framework with statistically validated multi-model learning
Intrusion Detection Systems (IDS) are considered critical security tools in ensuring network infrastructure security. However, recent studies on machine learning-based IDS systems are often constraine...
Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis
Mitophagy’s role in ulcerative colitis (UC) is not fully understood. This study explores mitophagy’s impact on UC and aims to create a diagnostic model. The transcriptomic datasets of patients with UC...
Gut site and sex-specific enrichment of bacterial taxa and predicted metabolic pathways in wild American black bear (Ursus americanus)
American black bears’ ( Ursus americanus ) omnivorous feeding strategy, simple gut morphology, and rapid transit time prevent regulation of the gut microbiome (...
Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors
Helicobacter pylori is one of the most prevalent bacteria, infecting more than 40% of the world’s population. Rising antibiotic resistance has created an urgent need for the discov...
Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term, randomized controlled trial
Background Amnestic mild cognitive impairment (aMCI), a common neurodegenerative disease affecting older adults, has garnered significant research interest over the past few years....
Intraperitoneal administration of NK-92 improves survival in xenografts of early and established ovarian cancer models
Ovarian cancer (OC) is a leading cause of gynecological cancer-related mortality. Management remains challenging as the disease frequently presents with intra-abdominal metastases at diagnosis, standa...
YOLO-BP for detection of multi-scale and high intra-class variation electrode cap defects in resistance spot welding
Inspection of electrode cap surface conditions is crucial in resistance spot welding. Current solutions largely rely on manual inspection or sensor-based approaches, with limited exploration into visi...
Social enrichment mitigates facial expressions and physiological indicators of short-term stress in horses
This study aimed to evaluate the ability of social noncontact environmental enrichment to facilitate social buffering and to characterize the emotional experience of horses subjected to restraint in s...
Design and acceptance assessment of a digital product passport for recycled and natural aggregate concrete elements
The construction sector accounts for a substantial share of global greenhouse gas emissions, making effective strategies for the reuse and recycling of building materials indispensable. However, relev...
Path planning for volumetric flask grasping based on visual guidance and multi-constraint optimization
In the automated operation of the chemical laboratory, using a robotic arm to pick up volumetric flasks is a core step of the operation process. By implementing reasonable path planning, the grasping...
Reconsidering the context in the relationship between material deprivation and self-rated health among older people in Italy
Both personal characteristics and contextual factors shape an individual’s perception of their health. This is especially true among older people. Micro and macro data from the 2018 Italian Multipurpo...
Global burden, trends and projections analysis of interstitial lung disease and pulmonary sarcoidosis in elderly adults (aged 55+ Years) based on GBD 2021
Background Pulmonary fibrosis is a severe chronic lung disease whose prevalence has been rising in recent years, representing one of the major respiratory health challenges globall...
Sustainability practices of accommodation sector representatives: The case of mountain protected area Serra da Estrela Natural Park (Portugal)
Research on the commitment of accommodation representatives to sustainability practices in protected areas is limited. In recent years, digitisation has become increasingly important in promoting plac...
Space use of juvenile green turtles along the North Pacific coast of Costa Rica
Understanding how threatened marine species use coastal areas and the extent of connectivity across different spatial and temporal scales is important for identifying critical habitats that can enhanc...
The analysis of competing hypotheses and expert witness testimony: Counteracting adversarial allegiance in witness credibility assessments?
Cognitive biases, such as adversarial allegiance, can compromise expert witness evaluations and contribute to wrongful convictions. Therefore, the application of debiasing strategies is essential. The...
Association between parenthood and survival among 30,386 patients hospitalized with COVID-19
Background Cross-reactive immune responses between endemic human coronaviruses and SARS-CoV-2 have been proposed as a potential factor mitigating COVID-19 severity. Because parents...
The neural transdifferentiation potential of bone marrow mesenchymal stem cells
Background Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by demyelination and neuronal degeneration. Currently, there is no treat...
Gaps in knowledge and use of artemether-lumefantrine among university students in Southwestern Nigeria: A cross-sectional study
Inappropriate use of antimalarial medications can accelerate the development of antimicrobial resistance (AMR), undermining treatment efficacy and public health goals. Artemether-lumefantrine (A/L) is...
Who would take part in a pandemic preparedness cohort study? The role of vaccine-related affective polarisation: Cross-sectional survey
Cohort studies are an important tool for public health research about emerging infectious diseases. Willingness to participate in research is associated with multiple factors. Little is known about th...