PLoS ONE
Articles in this Issue
Healthcare built environment and behavioural and physiological indicators of stress responses in autism spectrum disorder: Protocol for a mixed-methods systematic review
Introduction Autistic populations are more likely to need healthcare (HC) services due to co-occurring mental health issues, including anxiety and attention-deficit hyperactivity d...
Synergistic effects of high-temperature curing and elemental conditioning on red mud-based geopolymer: Compressive strength and immobilization
Red mud, a by-product of alumina refining, is accumulating rapidly and harming ecosystems. This study converted red mud and fly ash into a geopolymer (RFGP) to create value while mitigating waste. The...
TinyAct: A framework for real-time action recognition in the cloud through distillation learning
Human action recognition has become increasingly important for applications in security surveillance, healthcare monitoring, and smart environments. However, existing deep learning models typically re...
Popularizing health education, building public health facilities or regular screening? How to prevent schistosomiasis more effectively in African children
Due to the lack of safe drinking water and public health facilities, as well as the low popularity of health education, schistosomiasis is a prominent problem in African children. Considering that the...
Primary health care interventions targeting diabetes, hypertension or dyslipidemia in Malaysia: A scoping review
Introduction Despite the high prevalence of diabetes, hypertension and dyslipidemia among Malaysian adults, there are gaps in management and control of these diseases. Evidence sug...
Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells
Despite advances in treatment, chronic lymphocytic leukaemia (CLL) remains an incurable disease. Vδ1 + γδ T cells are reported to expand in CLL patients and to...
Single-cell RNA sequencing identifies microglial state changes associated with iTBS after ischemia–reperfusion injury
Understanding how to effectively treat neurological deficits after stroke remains difficult, as both the therapeutic targets and clinical outcomes are still uncertain. Although intermittent Theta burs...
Beyond individual markers: Prognostic value of the combined CEA/PNI score in metastatic colorectal cancer as a predictor of survival
Malnutrition and systemic inflammation significantly worsen the prognosis of oncology patients, contributing to 10–20% of cancer-related deaths. While the Carcinoembryonic Antigen (CEA) reflects tumor...
Pharmacogenetic strategies to mitigate cisplatin-induced ototoxicity in head and neck cancer: A cost-minimization analysis with the use of GSTP1 c.313A>G genotyping
Background Cisplatin is a cornerstone agent in the treatment of head and neck squamous cell carcinoma. Nonetheless, cisplatin is associated with significant ototoxicity, leading to...
Rhinovirus/enterovirus contribution to respiratory-associated hospitalizations in adults during respiratory seasons in Spain: A 6-year prospective study
Background Understanding the burden of acute viral respiratory infection-related hospitalizations is crucial for guiding research and development. Unlike influenza, respiratory syn...
Prevalence of depression, anxiety and stress and associated workplace stressors among healthcare workers in a tertiary hospital in Vietnam: A cross-sectional study
Background Healthcare workers face disproportionate risks of depression, anxiety, and stress, yet evidence from private tertiary hospitals in Vietnam remains limited. We aimed to e...
Effects of rehabilitation and behavior change interventions on physical capacity and physical activity behavior following lumbar surgery for degenerative disease: A systematic review and meta-analysis
Background Rehabilitation and behavior change interventions are commonly used after lumbar surgery to improve recovery, but their effects on physical capacity and physical activity...
Mapping sources of chronic disease-promoting products in retail environments: An analysis of co-location patterns of alcohol, tobacco, and fast-food retailers
Objective High densities of alcohol, tobacco, and fast-food retailers each pose increased risk of behaviors that contribute to chronic diseases. However, retail density studies typ...
Distributions of plantar loads are altered when walking in anxiety-inducing virtual settings but not under cognitive demand
Additional cognitive load and fall-related anxiety alter balance and locomotor control, independent of motor demands. Exposing participants to virtual elevation increases perceived cost of falling, an...
Impact of complex medication regimens on adherence in multimorbidity senior citizen – Study from Nepal
Background Elderly individuals often experience multiple comorbidities, requiring the use of several pharmacological therapies to improve their quality of life and extend life expe...
Analyzing the collaborative development needs of grassroots centers for disease control and prevention using the Kano model: A case study of China’s Chengdu–Chongqing Economic Circle
Background Advancing the development of centers for disease control and prevention (CDCs) has become a priority within global public health governance. However, public health gover...
Empirical analysis of AS-level cooperation on the internet considering geopolitical characteristics
The Internet is a complex socio-technical system intricately embedded within physical geography and political contexts. While previous studies have emphasized the technical aspects of its topological...
Multi-level determinants of tuberculosis treatment completion in rural Uganda: A cross-sectional study
Background Tuberculosis (TB) treatment completion rates in high-burden countries like Uganda often fall short of the WHO End TB Strategy target of ≥90%. This study evaluated multil...
Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation
Background Histone deacetylases (HDACs) regulate neuroprotection; however, Trichostatin A (TSA), an HDAC inhibitor, lacks clear molecular mechanisms and core targets in Alzheimer’s...
Ground motion inversion method based on generalized chaotic particle swarm optimization
Ground motion inversion is a core technology for revealing earthquake mechanisms and obtaining accurate source and site parameters. However, it has long been constrained by strong nonlinear coupling o...
Advancing aphasia psychological care in Ireland: A participatory study with people with aphasia and clinicians
Background Aphasia increases the risk of mental health issues, yet psychological care for aphasia (APC) is not routinely available. Given the significant psychosocial impact, APC r...
Serum proteomic changes in atopic dermatitis patients treated with cyclosporine
Background Despite significant advancements in atopic dermatitis (AD) treatment, the underlying pathogenesis remains unclear. Understanding flare and remission mechanisms is essent...
Power transformer online monitoring and state assessment method based on 2DCNN-BiLSTM multi-source feature fusion
As key power system equipment, real-time monitoring and accurate assessment of power transformers’ operating status are critical for grid safety. To address deficiencies in existing methods regarding...
Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice
Uricase-based drugs excel at treating refractory hyperuricemia and tumor lysis syndrome by directly degrading uric acid but are limited by immunogenicity. Here, we engineered RAW264.7 macrophages with...
Continuous remote monitoring of postoperative vital signs with the Biobeat patch: A multicenter prospective observational study
Objective This study, conducted under standard clinical conditions, evaluated the Biobeat wearable sensor in postoperative patients monitored over multiple days without human inter...