PLoS ONE
Articles in this Issue
Global folate deficiency among adolescent girls: A systematic review and meta-analysis
Introduction Adolescents have higher nutrient requirements than adults, as this stage accounts for approximately 40% of total adult weight gain, 45% of skeletal mass and about 15%...
Does electronic invoicing lead to stronger tax compliance? Evidence from China
This article investigates whether China’s fully digitalized electronic invoicing reform has improved tax compliance, using a staggered difference-in-differences approach. The results show that: (1) Th...
Identification and clinical implications of immune-related hub genes in psoriasis
Background Psoriasis, a chronic inflammatory skin disease affecting 2–3% of the global population, is driven by dysregulated immune responses. Despite advancements in biologic ther...
CDR-Net: A computerized framework to detect Alzheimer’s diseases and mild cognitive impairment
Alzheimer’s disease (AD) and mild cognitive impairment (MCI) are two dementia-related brain illnesses that are prevalent among elders in the twenty-first century. MCI is treated as the initial stage o...
Effect of HIV-1 subtype-specific Tat protein polymorphisms on Tat-TAR interaction
Introduction HIV Tat protein is responsible for HIV replication activation and interacts with the TAR RNA element for its function. Genetic polymorphisms in the Tat protein sequenc...
An exploratory analysis of changes in work values among nurses before and after pregnancy
This study aimed to investigate changes in work values among Japanese nurses before and after pregnancy, their return to work while managing childcare responsibilities, and the multifaceted factors in...
DSCANet: Integrating dual encoder and spatial cross-attention for polyp segmentation
Colonoscopy is a crucial clinical procedure for detecting colorectal polyps, which are strongly associated with the development of colon cancer. This endoscopic technique plays a vital role in both ca...
Normalizing flow based neural processes for Alzheimer’s disease progression prediction
As one of the most common neurodegenerative diseases, Alzheimer’s accounts for serious health problems worldwide. Accurate detection and prediction of this disease contribute to the health system for...
Kelp-stone ratio and bed roughness control green gravel stability under hydrodynamic forces
Kelp forests play a crucial role in marine ecosystems, providing habitat, food, and shelter for a variety of marine organisms. However, these ecosystems are facing significant threats, prompting the n...
Aligning labour force perceptions to job attraction, satisfaction and retention strategies in horticulture: A data-driven empirical study for Australian banana industry
Workforce stability in the banana industry is critical for productivity, fruit quality, and long-term sustainability. Labour shortages and high turnover can also lead to harvesting delays and handling...
Which turtle should I study? Uneven distribution of research effort across Testudines species
Understanding why some species are more often studied than others can provide valuable information on potential biases that research effort discrepancies can cause and help to direct future research t...
Diagnostic performance of DNA index for detection of high hyperdiploidy in childhood B-cell acute lymphoblastic leukemia
Introduction High hyperdiploidy (HHD) is the most common cytogenetic abnormality in childhood B-cell acute lymphoblastic leukemia (B-ALL) and is a pivotal finding for prognosis eva...
Orthognathic surgery and postoperative nausea and vomiting: An 11-year retrospective observational study
Orthognathic surgery (OGS) is now widely performed, and postoperative nausea and vomiting (PONV) remains a common complication. Gastric decompression using a nasogastric tube (NT) is generally conside...
An AI-based chatbot to support health-related social needs among pediatric primary care population: Protocol for a pilot randomized controlled trial
Unmet health-related social needs (HRSNs) are major drivers of poor health outcomes in early childhood. Children with unmet HRSNs are at greater risk for developmental delays, caregiver stress, and in...
The effect of health on refugees’ labor market integration: Evidence from a natural experiment in Germany
This paper analyzes the role of health for refugees’ integration into host countries’ labor markets. We exploit the quasi-random dispersal policies of refugees across regions in Germany to analyze the...
Academic workload and lifestyle predict emotional well-being among university students in the United Arab Emirates: A cross-sectional study
Background Stress is a prevalent issue among university students and is linked to adverse academic and emotional outcomes. While research emphasizes the roles of resilience, person...
Genome analysis of Lactiplantibacillus plantarum and Levilactobacillus brevis isolated from traditionally fermented Ethiopian kocho and their probiotic properties
Probiotics are essential for promoting health, with lactic acid bacteria (LAB) from traditional fermented foods like Ethiopian kocho offering valuable benefits. The objective of this study was to syst...
Balancing the supply and demand for taxonomy: An analysis of European taxonomic capacity and policy needs
Taxonomy is a cornerstone of biological science and essential to biodiversity policy, yet it faces persistent structural challenges collectively known as the “taxonomic impediment”. These include limi...
A novel multi-objective dynamic flexible job shop scheduling algorithm using reinforced learning based black widow spider algorithm
In today’s fast-paced manufacturing environments, solving flexible job shop scheduling problem (FJSP) has become essential due to swift design-to-manufacturing-to-consumer cycle and frequent disruptiv...
Subthreshold depression prevalence and influencing factors among nursing students in vocational schools: A cross-sectional study
Background Subthreshold depression (SD) is defined as a subclinical symptomatic state characterized by depressive symptoms that do not meet diagnostic criteria yet still impair qua...
Enhancing flood prediction through physics-driven typhoon feature engineering and machine learning
Typhoon-induced extreme floods pose severe threats to subtropical watersheds, yet systematic integration of typhoon physics into machine learning flood prediction remains limited. This study developed...
Regional and temporal patterns of partisan polarization during the COVID-19 pandemic in the United States and Canada
During the COVID-19 pandemic, public health measures emerged as highly polarizing topics in online discourse, with debates intensifying around specific policy implementations and events. This study in...
Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress
Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pathways including autophagy, proteasome-mediated degradation, antioxi...
Identification of an optimal exogenous gene insertion site (P–M) and establishment of a reverse genetics system for aMPV/A
Avian metapneumovirus subgroup A (aMPV/A) causes widespread infections in commercial poultry worldwide. The development of highly efficient viral vector vaccines is constrained by multiple factors, am...
Longitudinal brain health and neurological correlates of sexual strangulation in young adults: Study protocol for a prospective cohort study
Sexual strangulation (also referred to as choking during sex) has become increasingly prevalent among young adults and disproportionately affects females. Epidemiological studies indicate that more th...