PLoS ONE
Articles in this Issue
Study on the mechanical behavior and fracturing mechanism of rock containing two unparallel prefabricated fissures under uniaxial loading
As a natural material, rock is widely used in construction and building engineering, such as wall brick and road foundations. However, natural rock usually contains fissures and fractures, which great...
ATRA influences the differentiation and fusion of myoblasts by regulating Rarα/Pitx2, leading to abnormal development of the pelvic floor muscles (PFMs) in fetal rats
Anorectal malformation (ARM) is the most common congenital digestive tract anomaly in newborns, and children with ARM often have varying degrees of underdevelopment of the pelvic floor muscles (PFMs)....
Development of a layer-wise in-situ laser-based dimensional monitoring system with post-mechanical characterization of synthesized polylactic acid 3D prints in FDM additive manufacturing
High-dimensional accuracy is difficult to obtain in 3D printing techniques such as Fused Deposition Modeling (FDM). The study was conducted in two phases. In the first phase, the causes of dimensional...
Comparison of OneChoice AI-based clinical decision support recommendations with infectious disease specialists and non-specialists for bacteremia treatment in Lima, Peru
Bacteremia is a major contributor to global morbidity and mortality, particularly in low- and middle-income countries where diagnostic delays and empirical antimicrobial misuse exacerbate resistance....
Enhancing generalizability in classification of peripheral neural recordings with graph neural network
The peripheral nervous system plays a crucial role in facilitating communication between biological systems. However, decoding neural signals from peripheral nerve recordings remains a challenge due t...
A comparative analysis of academic outcomes in blended versus traditional instructional approaches: An examination within the context of the National Medical Licensing Examination
Objective This research examines the distinctions between the blended teaching approach and the traditional instructional method within the context of pathophysiology, utilizing th...
A novel SLC20A2 nonsense variant and mechanistic studies of primary brain calcification
Primary brain calcification (PBC) is a rare neurodegenerative disease featured by bilateral brain calcifications and exhibiting high phenotypic and genetic heterogeneity. The clinical manifestations m...
Evaluation of the predictive accuracy of QUICKI and McAuley indices for insulin resistance in adolescents: Insights from a cross-sectional study
Different indirect methods have been developed to assess insulin resistance (IR), though their validation has been limited to adult populations. In this sense, the study aim is to compare the predicti...
Atomic representation and algorithms for polytomous knowledge spaces
Classical knowledge space theory provides a rigorous framework for cognitive diagnosis, but its dichotomous response model fails to capture the graded nature of knowledge. While recent research has ex...
Knowledge, attitudes, and practices (KAPs) on agrochemical use in small-scale farmers near Lake Tana, Ethiopia: Impacts on public and aquatic ecosystem health
Agrochemical application is essential for increasing agricultural production and achieving Sustainable Development Goal 1 to secure worldwide hunger. In Ethiopia, there is haphazard use of pesticides...
Self-efficacy and self-regulated learning strategies as significant predictors of english writing proficiency in Chinese EFL senior high school students
Self-efficacy and self-regulated learning strategies are crucial importance for enhancing the writing proficiency of foreign language learners. This study employed a cross-sectional design to examine...
Socio-spatial logic of demolition and relocation in urban China
While urban demolition ( Chai Qian ), a process encompassing housing removal and resident relocation, is a distinctive feature of China’s urban transformation,...
Pretraining effective T5 generative models for clinical and biomedical applications
This paper presents a study of the impact of corpus selection and vocabulary design on the performance of T5-based language models in clinical and biomedical domains. We introduce five different T5-EH...
The association between RDW-to-platelet ratio and in-hospital mortality in critically ill stroke patients: A retrospective cohort study based on the eICU database
Objective The red cell distribution width-to-platelet ratio (RDW-to-platelet ratio, RPR) is a potential biomarker of inflammation and bone marrow function. This study aimed to inve...
Hybrid feature-selection and diversity-guided stacking framework for interpretable ensemble learning: Application to COVID-19 mortality prediction
Background Reliable predictive modeling in high-dimensional biomedical data requires a balance between accuracy, interpretability, and computational efficiency. However, existing e...
Non-lethal imaging and modeling approaches for estimating dry mass in aquatic larvae
Body mass is crucial for scaling and comparing physiological rates. Specifically, dry body mass is important in determining an organism’s metabolic rate since it excludes metabolically inactive water...
COVID-19 in hemodialysis patients: New insights into metabolomic profile dynamics from 60 days pre- to 60 days post-diagnosis
Background Maintenance hemodialysis patients experience higher morbidity and mortality from COVID-19, partly due to comorbidities like diabetes and cardiovascular disease. However,...
Rural residence and mental health among US Veterans: Findings from the Millennium Cohort Study
Background Military veterans are at higher risk of mental health conditions compared to civilians. Some residential characteristics may increase the odds of mental health condition...
Sucralose inhibited cell survival through the activation of ER stress in human endothelial progenitor cells
Sucralose, a widely utilized non-caloric sweetener, is frequently added to food and beverage products as a sugar substitute aimed at lowering energy consumption and reducing obesity-related health ris...
Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation
Epilepsy is a chronic neurological disorder characterized by recurrent seizures, with its onset and progression closely linked to neuroinflammation, where abnormal activation and migration of microgli...
Safety and effectiveness of stereotactic radiosurgery for larger hemangioblastomas (>2cc): A multi-center retrospective study
Introduction Hemangioblastomas (HGB) are the most common primary intra-axial tumors in the posterior fossa in adults, with an overall occurrence of 7–10%. They occur sporadically o...
Correction: Geochemical signatures in plastic debris from the Curonian Lagoon, Lithuania
Wave frequency selection method for hyperspectral hyperspectral remote sensing image based on SSGIE-KFCM algorithm
In hyperspectral remote sensing image band selection, there exist issues such as poor nonlinear separability, high redundancy, and the tendency of traditional optimization algorithms to get trapped in...
Coriander leaf essential oil as an immunomodulator: Enhancing NF-κB-driven RAW246.7 murine macrophages response to Candida albicans
Coriander is a cultivated aromatic herb used as a culinary ingredient and in traditional medicinal treatments worldwide. Coriander essential oil contains various bioactive constituents with antibacter...
Toward compassionate workplaces: Employers’ and employees’ perspectives on serious illness, dying, death, and grief: Findings from a nationwide online survey in Germany
Background Experiences of serious illness, dying, death, and grief in the workplace significantly affect employee well-being, productivity, and organizational culture. Despite incr...