PLoS ONE
Articles in this Issue
General practice interventions to reduce cardiovascular disease risk in patients with severe mental illness: A scoping review
Background People with severe mental illness (SMI), including bipolar disorder, major depression, and schizophrenia, face significantly increased morbidity and mortality from cardi...
Retraction: Isolation and molecular characterization of extended spectrum beta lactamase producing Escherichia coli from chicken meat in Pakistan
Hybrid attention-based multi-class classification of Ethiopian legal texts using deep learning
The exponential growth of legal documents in Ethiopia has created an urgent need for efficient and accurate automated classification systems tailored to the country’s unique linguistic and legal conte...
Association between maternal hemoglobin concentration levels and preterm birth clinical subtypes: A retrospective, observational, multicenter study
Background As a routine component of antenatal care, hemoglobin (Hb) testing can detect underlying abnormalities in pregnant women, thereby guiding clinical interventions. However,...
Captive environment induced greater physiological changes than probiotic treatment in Pelophylax nigromaculatus
Ex situ conservation of amphibians is an effective countermeasure against various threats to populations in situ ; however, it may entail ph...
Prenatal exposure to polycyclic aromatic hydrocarbons and birth outcomes in a pregnancy cohort in Nairobi, Kenya
Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to lower birth weight (BW) and shorter gestational age (GA) at delivery. Most research has focused on populations in high-i...
“We’re getting older and things are changing”: Qualitatively exploring older adults’ everyday experiences in relation to early changes in mobility
Mobility can require skills from ambulating to driving and using public transportation. The onset of mobility impairments has been linked to reductions in physical function, social participation, heal...
Fishing for millennia: Effects and impacts of prehistoric fishing in the Syltholm Fjord, Denmark
This study investigates the long-term impacts of human subsistence strategies on the fauna and ecosystem of Syltholm Fjord, Denmark, from the Late Mesolithic to the Bronze Age (c. 4500–800 cal BCE). D...
The impact of walking on creative thinking: A systematic review and meta-analysis
Background Walking is associated with many benefits, from improved mental health to a reduced risk of mortality – but can it boost creative thinking? Current evidence suggests a po...
Methods for analytical validation of novel digital clinical measures: A simulation study
Analytical validation is a crucial step in the evaluation of algorithms that process data from sensor-based digital health technologies (sDHTs). Analytical validation of novel digital measures can be...
Diagnostic performance of abbreviated non-contrast liver MRI for detecting synchronous colorectal liver metastases
Background Colorectal cancer (CRC) is a leading malignancy, and colorectal liver metastases (CRLM) are common. Accurate detection is critical for staging and treatment planning. Al...
Correction: How Etuaptmumk/Two-Eyed Seeing is used in Indigenous health research: A scoping review
Live fish highway: Uncovering the pathways that move millions of minnows across the United States
The spread of aquatic invasive species and pathogens over the last few decades has disrupted sportfishing, imposed economic costs on local industries, and threatened freshwater ecosystems. A significa...
Analyzing the performance of deep learning splice prediction algorithms
SpliceAI is the leading tool for predicting splice-altering variants, but restrictive licensing limits clinical adoption. While open-source implementations have been published with author-reported com...
Monitoring land degradation by soil salinity using Sentinel-2 satellite data and GIS techniques: A case study of Sabkhat Ghuwaymid, Saudi Arabia
Soil salinity drives land degradation and vegetation loss, posing a significant challenge for agriculture and global efforts to combat desertification. Enhancing land degradation monitoring methodolog...
Short-term coastal forest responses to a hurricane-scale freshwater and saltwater flooding experiment
Coastal upland forests are exposed to intensifying precipitation regimes and sea level rise, increasing tree mortality and transforming these coastal forests into wetland ecosystems. While the ultimat...
Algorithm-assisted interpretation of cyclic and differential pulse voltammetry for cardiac troponin detection
Cardiovascular disease remains a leading cause of mortality worldwide, and rapid identification of cardiac biomarkers is essential for early detection. Electrochemical voltammetry techniques, particul...
Unraveling dimethylformamide-induced neutrophilic differentiation in HL-60 cells: A proteomic and functional comparison with dimethyl sulfoxide
The differentiation of HL-60 cells into neutrophil-like cells is widely used to study neutrophil functions, yet no comprehensive proteomic analysis has been conducted on dimethylformamide (DMF)-induce...
Usefulness of lung sound data collection using Skeeper SM-300® device: A pilot study
Background Digital stethoscope has been introduced to clinical practice and are developing in many aspects. Overwhelming pandemic requires non-contact healthcare support, and recen...
Light quality-regulated anthocyanin biosynthesis in Lilium leichtlinii subsp. maximowiczii bulbs: A multi-omics perspective
This study elucidated the molecular mechanisms governing light spectrum-regulated coloration and secondary metabolism in Lilium leichtlinii subsp...
Survival and life expectancy inequality by gender in Thai provinces: Trends from 2015 to 2023
Background Gender disparities in survival and life expectancy are indicative of broader health and socio-economic inequalities. This study examines temporal trends and subnational...
Constructing HIV/AIDS in Chinese media (2010–2024): A mixed-methods study
In China, where HIV/AIDS remains one of the leading causes of infectious disease-related mortality, traditional media significantly shape public perceptions amid persistent prevention challenges. This...
Molecular cytogenetic mapping of Secale strictum introgressions in a perennial tetraploid rye and its diploid progenitor
Perennial rye offers a means to reduce soil disturbance in water-limited cropping systems; however, the use of interspecific germplasm is often constrained by variable fertility and structurally heter...
KIF11 promotes rheumatoid arthritis pathogenesis by activating M1 macrophage polarization and promoting inflammatory cytokine secretion
Background and Objective KIF11, a mitotic kinesin, has been implicated in oncogenesis, but its specific role and mechanism in RA pathogenesis remain largely unexplored. We aim to e...
Epigenetic clocks moderate the impact of marital status transitions on health in older adults
Chronological age is commonly used to study aging, but biological aging may more accurately reflect cumulative life experiences and psychosocial stressors. This study examines whether epigenetic clock...