PLoS ONE
Articles in this Issue
Reinforcement learning-controlled differential evolution with L-BFGS refinements
Differential evolution has become one of the mainstream solvers for complex optimization problems due to its concise structure and strong global search ability. However, the performance of the DE algo...
Alaska pollock protein as a functional dietary source for promoting skeletal muscle hypertrophy and lipid metabolic remodeling
Alaska pollock protein (APP) promotes skeletal muscle hypertrophy, particularly in fast-twitch fibers. Using a time-controlled feeding model, plasma collected 90 min after APP intake markedly enhanced...
Social disparities in the frequency and severity of triple-negative breast cancer at diagnosis in a university hospital in Paris, France: confronting race and ethnic blindness
Triple-negative breast cancer (TNBC), an aggressive subtype with poor prognosis, is of higher frequency in African American women and women of Sub-Saharan African origin. In France, legal constraints...
Feasibility of the Xemio app for breast cancer survivors in a clinical setting: Adherence, acceptance, and side effect monitoring (CTCAE vs. QoL)
Breast cancer is the most common cancer worldwide, posing significant challenges for survivors, including long-term physical, emotional, and cognitive effects. Mobile health (mHealth) tools provide ne...
Validation of deep learning enabled web based and smartphone optimized application RadAnalyzer to measure vertebral heart size and vertebral left atrial size in dogs
Background Objective radiographic measures of heart size including vertebral heart size (VHS) and vertebral left atrial size (VLAS) are associated with inter and intra-observer var...
Challenges and possibilities in offering support to family caregivers to persons with dementia of non-European background: A qualitative study
Background With population ageing and increasing ethnic diversity in Europe, it is essential to support the growing number of family caregivers (FCs) who provide daily care for per...
A novel isolated phage targeting Pseudomonas aeruginosa demonstrates therapeutic potential
Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium responsible for severe infections such as pneumonia, septicemia, and keratitis. It poses a significant treatment c...
Evaluation of the diagnostic value of the Modified Evan’s Blue Dye Test for assessing aspiration in tracheostomized critically ill patients: A systematic review and meta-analysis
Dysphagia and aspiration are common complications in tracheostomized critically ill patients. The Modified Evan’s Blue Dye Test (MEBDT) is a non-invasive, bedside, adjunctive rule-in signal for aspira...
Integrative bioinformatic analysis prioritizes TIMP1 and FN1 as angiogenesis-related candidate genes in diabetic foot ulcers
Background Diabetic foot ulcers (DFUs) represent a severe chronic complication of diabetes and are characterized by persistent impairment of wound healing, accompanied by defective...
Enacting the curriculum: The interplay of pedagogical beliefs, motivation, and fidelity
Background Curriculum fidelity – the balance between strict adherence to prescribed curricula and context-responsive adaptation – represents a critical challenge in educational imp...
Quantitative genetic analysis of respiratory function and related traits in Bulldogs, French Bulldogs and Pugs
Brachycephalic Obstructive Airway Syndrome (BOAS) is a common health issue in brachycephalic breeds like Bulldogs, French Bulldogs, and Pugs, linked to their distinctive skull morphology. Despite its...
Expression of Concern: Enhancing speaker identification through reverberation modeling and cancelable techniques using ANNs
Interpretable candidate drug prioritization and explanation framework across-medical knowledge graphs based on graph embedding models: A case study of type 2 diabetes
Objective Addressing the challenges in elucidating the mechanisms of complex diseases such as Type 2 Diabetes Mellitus (T2DM), this study aims to construct a domain-specific cross-...
Correction: Association of health literacy with quality of life and health outcomes among school-age children in Japan: A cross-sectional study
Unveiling the shadow economy in emerging markets
This study examines the direct role of the shadow economy in economic growth and its indirect roles through interaction with tax burden, institutional environment, foreign direct investment, trade ope...
Screening for eating disorders and low energy availability in female trail runners: A cross-sectional study
This cross-sectional study aims to screen for eating disorders and low energy availability, as well as identify associated factors among female trail runners. An online survey was used, collecting par...
Earliest evidence for invasive mitigation of dental caries by Neanderthals
Neanderthal medical knowledge has long attracted scholarly interest. Evidence suggests they cared for sick, injured, and elderly group members, with possible use of medicinal plants. However, it remai...
COVID-19 pandemic stressors and their longer-term association with young people’s wellbeing
There is a significant body of research on adolescent wellbeing during the pandemic but less attention to the pathways through which the pandemic might be driving longer-term impacts on wellbeing. Thi...
Emotion-focused therapy and forgiveness in the older population: Protocol for a feasibility randomized controlled trial
Over recent decades, Emotion-Focused Therapy, aging, and forgiveness have garnered significant attention in the field of psychology. However, there is a lack of studies on Emotion-Focused Therapy and...
Exploring pathways leading to stillbirths and gaps in postnatal care among affected women in a rural north Indian district: A qualitative study using the social autopsy lens
Background Globally, stillbirth is a silent yet significant contributor to perinatal mortality. India has several national maternal and child health programs, yet, the stillbirths...
Classification of soft decision-making methods via fuzzy parameterized fuzzy soft matrices and their performance-based statistical analysis in machine learning
This study provides a comprehensive evaluation and classification of 35 soft decision-making (SDM) algorithms based on fuzzy parameterized fuzzy soft matrices ( fpfs...
Role of activity and fibrosis in the MASLD atherogenic momentum through advanced lipidomics
Introduction MASLD is linked to dyslipidemia, but it remains unclear whether this alteration depends more on disease activity or fibrosis....
Ecological strategies and extinction risk in butterflies and macro-moths of Great Britain and Ireland: A trait similarity network approach
Trait-based analyses of extinction risk often examine individual traits independently, which can obscure how combinations of traits define broader ecological strategies. Here, we apply a network-based...
Development of an asthma policy model for Canada: Lifetime Exposures and Asthma outcomes Projection
Objectives To address the need for health policy planning focused on early interventions for asthma, we developed the Lifetime Exposures and Asthma outcomes Projection (LEAP), a re...
Neutrophil-to-lymphocyte and neutrophil-to-platelet ratios for predicting 28-day mortality in sepsis: A retrospective cohort study
Objective This study aimed to evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and neutrophil-to-platelet ratio (NPR), alone and in combination with procal...