PLoS ONE
Articles in this Issue
Multivariate genetic architecture of age-related eye disease
At present, the genetic architecture underlying traits linked to Age-related eye disease (ARED) remains largely unexplored. We utilized Genomic Structural Equation Modeling (Genomic-SEM) and various P...
Seafood procurement auctions in the presence of origin falsification: Price-only auction versus scoring auction
Origin falsification in seafood procurement is a significant issue that threatens supply chain integrity and distorts market competition. Despite advances in origin detection technologies, this proble...
Synthesis of magnetic biochar using Bauhinia variegata leaves through one-pot hydrothermal process to degrade malachite green dye by Fenton-like catalysis
This study reports the facile one‑pot hydrothermal synthesis of a magnetite‑embedded magnetic biochar (Bv‑MBC) derived from Bauhinia variegata leaves and its ap...
Economic evaluation of finotonlimab plus bevacizumab as first-line therapy for advanced hepatocellular carcinoma
Objective To compare the cost-effectiveness of dual-agent group (finotonlimab combined with a bevacizumab biosimilar) (SCT510) versus sorafenib as first-line treatment for advanced...
Burnout among anesthesia personnel in Thailand: A national survey of workload, personality traits, and resilience
Background Burnout is a critical issue affecting anesthesia personnel, with implications for both provider well-being and patient safety. This study aimed to examine the prevalence...
What gets Redditors talking? Predicting discussion initiation and size on Reddit
Understanding which posts spark conversation, and how large those conversations grow, is vital for moderation, resource allocation, and anticipating information cascades on Reddit and other social pla...
Evidence on strategies promoting discharge planning participation in patients with chronic heart failure: A scoping review protocol
Introduction Chronic heart failure (CHF) poses a significant global healthcare burden. High readmission rates, driven by inadequate discharge preparation and suboptimal transitiona...
Response surface methodology to optimize the green synthesis process of cefotaxime sodium: Collaborative improvement of yield, crystal form control and environmental benefits
Objective Based on the response surface method combined with the concept of green chemistry, the synthesis process of cefotaxime sodium (CTX) was optimized, taking into account pro...
Single-chain human Follicle-stimulating hormone promotes ovarian and testicular growth and improves pregnancy performance in mice
Follicle-stimulating hormone (FSH) is a central regulator of folliculogenesis and reproductive function. To enhance its stability and pharmacological activity, we designed a single-chain (sc) gonadotr...
Analysis of the population structure and physiological status differences of yangtze finless porpoises (Neophocaena asiaeorientalis) across habitats in Poyang lake
To investigate the physiological status of Yangtze finless porpoises (YFPs) in Poyang Lake and assess health conditions across different habitats at a mesoscale geographical level, physical examinatio...
Public sentiment and thematic evolution in the metaverse: A large-scale computational analysis of Twitter discourse
This study investigates public perception of the metaverse through a large-scale computational analysis of 52,874 English-language tweets. Leveraging sentiment analysis tools (VADER and RoBERTa) and u...
Physically plausible balloon dynamics via position-based constraints and geodesic-weighted forces
This paper presents a lightweight balloon‐dynamics method, built on the Position-Based Dynamics (PBD) framework, that reproduces real-time inflation–deflation–rotation as air is injected and released....
Neural and behavioral evidence of free shipping on consumer decision making
The rise in online shopping has heightened consumer frustration, as many are reluctant to pay additional charges. Understanding the neural mechanisms of decision-making underlying this resistance coul...
Cost-effectiveness analysis of mepolizumab among patients with severe asthma from the Chinese societal perspective
Background Patients with severe asthma, particularly those with an eosinophilic phenotype, face a limited array of treatment options. The Mepolizumab Efficacy in Patients with Seve...
Effects of β-alanine supplementation on kickboxing-specific anaerobic performance, neuromuscular power, and strength endurance: A randomized, double-blind, placebo-controlled trial
β-Alanine (BA) elevates skeletal muscle carnosine and may improve repeated high-intensity performance; however, evidence in kickboxing is limited. This study investigated the effects of 4-week BA supp...
Bioinformatics approach to identify potential biomarker and drug target for the clinical and subclinical mastitis disease in dairy cattle
Mastitis in dairy cattle is a serious issue that affects not just the animals but also has broad social, cultural, economic, and human consequences. It does in a wide variety of ways and the most rema...
The effect of plyometric training on physical performance in youth soccer players: A randomized controlled trial with maturation status as a covariate
Purpose Plyometric jump training (PJT) is an effective means of developing speed, strength, and neuromuscular parameters in youth athletes. However, the effect of PJT on performanc...
Parental knowledge of early childhood caries and its association with bottle-feeding practices: A cross-sectional analysis in the Riyadh Province, Saudi Arabia
Background Early childhood caries (ECC) remains a major public health concern globally and is highly prevalent in Saudi Arabia. Parental knowledge, attitudes, and feeding practices...
Influence of parenting style on the self-esteem of adolescents and the factors associated with low self-esteem: An institutional based cross-sectional study in Tokha municipality, Nepal
Adolescence is a crucial developmental phase where self-esteem significantly impacts mental health and life outcomes. Low self-esteem is associated with depression, academic struggles, and risky behav...
GBCapsNet: A calibrated capsule network for automated gallbladder disease diagnosis via ultrasound imaging
Gallbladder diseases present a significant clinical challenge due to their diverse manifestations and the difficulty of accurate interpretation in ultrasound imaging. Manual assessment of gallbladder...
Aerobic capacity and muscular strength in 179 Norwegian men and women aged 20–59 years with a substance use disorder: A cross-sectional study
Research has shown a robust inverse association between maximal aerobic capacity and muscular strength, and lifestyle related diseases and mortality. People with a substance use disorder have a higher...
Field investigation of the bearing behavior of grouted gravel pile composite foundations in Karst Terrain
The extensive underlying karst in southwestern and southern China presents significant challenges for deformation control in railway and highway subgrades. This paper proposes an integrated technology...
Baleen hormone analyses reveal stress and reproductive life-history of the critically endangered Rice’s whale (Balaenoptera ricei)
The Rice’s whale ( Balaenoptera ricei ) is a recently described species of baleen whale found in the Gulf of Mexico. With fewer than 50 adults remaining, the Ri...
Health related quality of life among hypertensive adults living in rural Vietnam: Results from a cluster-randomised controlled trial
Background There is a growing burden of hypertension (HTN) among adults living in rural Vietnam, which is associated with reduced health related quality of life (HRQoL). Few commun...
Both conventionally and organically fertilized tomatoes maintain fruit quality through uncontrolled green peach aphid infestation, with a transcriptional shift towards catabolism
Aphids are a major pest of greenhouse-grown temperate crops, responsible for billions in crop damage yearly. As organic agriculture rapidly grows in popularity, understanding how plants grown under or...