PLoS ONE
Articles in this Issue
Correction: Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites
Assessing National Health Research System in a resource-limited setting: Insights from Indonesia
High-quality health research is essential for evidence-based policymaking and health system strengthening. Indonesia has undergone major reforms in its health research governance. However, the country...
How does self-control influences college students’ smartphone dependence: The chain mediating effect of mental toughness and social adaptability
The study aimed to investigate the mediating roles of mental toughness and social adaptability in the relationship between self-control and smartphone dependence among college students. In January 202...
Phenological shifts in mating and lambing timing in response to climate change in Urial wild sheep (Ovis vignei) populations in Iran
Climate change is increasingly disrupting ecological processes across arid and mountainous biomes, with profound implications for the reproductive phenology of large herbivores. These species are espe...
Study on plugging law and plugging removal effect of pre filled screen in natural gas hydrate argillaceous silt reservoir
To address the issue of production decline caused by natural gas hydrate blockage in offshore screen pipes, optimization experiments for high-efficiency rotary water jet backflushing technology were c...
Electrolyte imbalance in Asphyxiated term neonates: Incidence, predictors, and outcomes from a prospective cohort study in Northern Uganda
Background Birth asphyxia is a major cause of neonatal morbidity and mortality, particularly in low-resource settings. Hypoxia and metabolic derangements that occur during asphyxia...
Tuberculosis in households with infectious cases in Kampala city: Harnessing health data science for new insights on an ancient disease with persistent, unresolved problems
Tuberculosis (TB) is prevalent in Uganda and overlaps with a high rate of HIV/TB coinfection. While nearly all hospital-based TB cases in Kampala, the capital of Uganda, show clear TB symptoms, 30% or...
Immunomodulatory effects of a multi-component pharmacological intervention on diabetic peripheral neuropathy in type 2 diabetic rats: An exploratory study
Background Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM) and is closely linked to immune and inflammatory dysregulation. Multi-co...
Estimation of battery SOC using a combined approach of temporal convolutional networks and Unscented Kalman Filter
In recent years, power batteries have been widely used in electric vehicles, and the evaluation of state of charge (SOC) is an important parameter in battery management systems. Therefore, in this pap...
Perceptions, attitudes, behaviours and barriers towards obesity among people with obesity and health care professionals in Indonesia: An exploratory online survey
Background The Awareness, Care, and Treatment In Obesity maNagement Asia Pacific (ACTION APAC) online survey identified perceptions, attitudes, and barriers to effective obesity ca...
Balloon pressure monitoring for radial artery hemostasis after transradial coronary procedures: protocol for a randomized controlled trial
Background Forearm radial artery occlusion (RAO) is a common complication after transradial coronary procedures. Traditional patent hemostasis, relying on operator-dependent assess...
Comparison between enzyme-linked immunospot assay and intracellular cytokine flow cytometry assay of cytomegalovirus-specific T-cell response in healthy participants
Human cytomegalovirus (HCMV) usually establishes a lifelong latent infection after primary infection. Reactivation occurs sporadically and is controlled by cell-mediated immune response (CMIR). Monito...
Catheter body-surface fixation after transurethral prostate resection: A low-value nursing practice as evidenced in a randomized controlled trial
This randomized controlled trial is aimed at evaluating whether external fixation of the urinary catheter to the body surface represents a low-value nursing intervention for patients undergoing transu...
Finite sample size errors in the context of multiple error sources in quantitative medical imaging: An evaluation for breast magnetic resonance diffusion-weighted imaging
Background Selecting appropriate sample sizes in magnetic resonance imaging studies is a complex process that requires to balance statistical rigor with the practical challenges of...
Protective effects of Fraxinus xanthoxyloides bark in alloxan-induced diabetic rats: A phytochemical and pharmacological approach
Fraxinus xanthoxyloides Wall. ex DC (Family-Oleaceae) is a tiny tree found in arid highlands, often referred to as “Afghan ash”. This study aimed to explore F....
Reconstruction of a segmental bone defect using vascularized tissue-engineered bone substitutes: An animal study
Background Repairing large segmental bone defects remains a major challenge in orthopedics, with conventional autografting and allografting limited by donor shortages and high comp...
Correction: Mammographic Assessment of a Geographically Defined Population at a Mastology Referral Hospital in São Paulo Brazil
Preschool and primary school teachers’ attitudes toward students with type 1 diabetes: A cross-sectional study
Introduction Type 1 diabetes mellitus (T1DM) is the most common chronic endocrine disorder in childhood, making teachers key agents in ensuring a safe school environment. The main...
Deep learning-based arterial waveform analysis for predicting postoperative cerebrovascular events in pediatric patients with Moyamoya disease
Background Postoperative cerebrovascular events, including transient ischemic attacks, infarctions, and hemorrhages, remain a significant concern in pediatric patients with Moyamoy...
Trends in the burden of sickle cell disorders in Sierra Leone, 1990–2023: An analysis of Global Burden of Disease Study 2023 estimates
Background Sickle cell disease is a major cause of childhood mortality in sub-Saharan Africa, yet country-specific burden estimates for high-prevalence settings in West Africa rema...
Eosinophil count trajectories are associated with the prognosis of acute myocardial infarction patients: Insights from ICU data analysis
Objective Previous clinical studies have demonstrated conflicting evidence regarding the relationship between eosinophil (EOS) count and adverse outcomes in acute myocardial infarc...
A multicenter, randomized, parallel-group confirmatory study protocol to evaluate the efficacy of Soft Protector CPC, a novel oral mucosal protectant, in preventing oral mucositis and alleviating pain in patients with breast cancer
Oral mucositis is a frequent and debilitating adverse event observed in patients undergoing chemotherapy or radiotherapy. Current management strategies are limited in duration, require frequent applic...
Epidemiological patterns and healthcare utilization among malaria patients in Sorong City, Papua, Indonesia: A cross-sectional analysis of national surveillance data
Objectives Malaria remains endemic in Indonesia, with high transmission rates observed in the Papua region. Routine surveillance data are essential to inform service delivery and o...
An analysis of pediatric retinoblastoma medical malpractice litigation
Background Retinoblastoma is a cancer of the retina that is most commonly diagnosed in the pediatric population. Unfortunately, this cancer can spread, leading to poor outcomes suc...
Cross-context qualitative synthesis of a mobile obstetric referral emergency system (MORES) in Ghana and Liberia
Background To address the delayed provision of obstetric emergency care in Ghana and Liberia, our team previously implemented a mobile obstetric emergency referral system (MORES) c...