PLoS ONE
Articles in this Issue
An optimized three-laser 27-color spectral flow cytometry panel for multi-organ profiling in mice
While high-dimensional flow cytometry plays critical roles in resolving complex cellular networks, there remains a scarcity of comprehensive panels for the simultaneous profiling of diverse mouse cell...
Herpes simplex virus type-1 ocular infection in thrombospondin-1 deficient C57BL/6J mice
Herpes simplex virus type 1 (HSV-1) corneal infection triggers an immunopathological response and corneal neovascularization leading to vision impairment. Thrombospondin-1 (TSP-1) is a matricellular p...
Perinatal mental health among South Asian immigrant women in Canada: A scoping review protocol
Perinatal mental health concerns are common and may be heightened among immigrant populations because of migration-related stressors, social isolation, stigma, language barriers, and limited access to...
Partisan differences in healthcare decision-making: Evidence from a vaccine experiment
Policymakers use information campaigns to alter health behaviors, but their effectiveness depends on how the information compares to viewers’ initial beliefs and their perceptions of its value. In Aug...
Face validity of a dyslexia screening instrument for secondary students
Dyslexia is a specific learning difficulty marked by persistent challenges in reading accuracy, fluency, and word recognition despite adequate intelligence and instruction. In secondary schools, many...
Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency
Monophosphoryl lipid A (MPLA) and the saponin-MPLA nanoparticle adjuvant (SMNP) are known immunostimulants used as adjuvants in vaccines to boost immunity. These adjuvants are under investigation for...
A space syntax approach to sustainable design for public spaces in historic cities
Historic cities, as carriers of urban culture and history, have spatial organizations and usage patterns that directly impact district vitality and sustainability.Addressing the common problems in his...
Data-driven analysis of heterogeneous gait subgroups and ground reaction forces based on integrated center of pressure–center of mass dynamics in poststroke hemiparesis
Introduction Hemiparetic gait is characterized by abnormal ground reaction forces (GRFs) with impaired control of the center of mass (CoM) relative to the center of pressure (CoP)....
Views on mental health recovery in primary and community mental healthcare services in Thailand: A qualitative study
Introduction Strong community-based services and healthcare providers with a clear understanding and positive attitudes towards recovery, are central to delivering good quality men...
Postural control and knee joint importance during quiet standing in individuals with anterior cruciate ligament reconstruction
There is obscurity about the role of the knee joint during quiet standing (QS) postural control. Examining the knee joint’s contribution during QS in individuals with damaged knee proprioception can h...
The spatiotemporal evolution of toponymic cultural landscapes in Hebei Province, China, and its influencing factors
Current research on toponymic cultural landscapes lacks systematic attention to geographical transition zones and often neglects the interpretation of long-term evolutionary processes and driving mech...
PAC1 receptor agonist maxadilan alleviates corneal inflammation in a murine model of LPS-induced ocular inflammation
Ocular inflammation is a leading cause of visual impairment and blindness worldwide. Systemic bacterial infections can spread hematogenously, resulting in endogenous endophthalmitis. These infections...
Assessment of waterlogging tolerance in tea genotypes through morpho-physiological and biochemical profiling
Tea is one of the major economic crops in Bangladesh, however, its productivity is severely constrained by waterlogging stress arising from erratic climatic changes. A significant knowledge gap persis...
Automated concrete crack detection enhanced by deep learning and generative adversarial networks
Cracks on the surface of concrete structures are an obvious indication of their condition. However, traditional visual inspection methods are significantly influenced by human factors. They are accura...
Academic and psychological determinants of mental stress among medical students in Dhaka: A multinomial logistic regression approach
As stress among medical students is a global health concern due to comprehensive academic engagements, this study aimed to assess the educational and psychological factors related to mental stress amo...
Adverse effects of removable orthodontic aligners: A systematic review with single-arm meta-analysis
Background Removable orthodontic aligners are widely used due to their aesthetic appeal, removability, and perceived comfort. However, evidence regarding their potential adverse ef...
Cancer-associated fibroblast subtype signature gene predicts survival and immunotherapy response in sarcoma
Background Sarcomas show heterogeneous responses to immune-checkpoint blockade (ICB), and cancer-associated fibroblasts (CAFs) are considered to shape the tumor immune microenviron...
Chronic CBD treatment differentially modulates neurobehavioral outcomes and endocannabinoid signaling in an aged HIV-1 Tat transgenic mouse model
As the population of older individuals living with HIV continues to expand, identifying non-euphoric therapeutic interventions for HIV-associated complications is essential. While cannabidiol (CBD) ha...
HPV vaccination intention and its association with vaccine hesitancy and health beliefs among unvaccinated Chinese medical college students: A cross-sectional study
Background Human papillomavirus (HPV) infection poses a significant public health challenge, and HPV vaccination uptake among Chinese college students remains suboptimal. Therefore...
A feature-efficient dual-task machine learning framework for predicting bone mineral density and osteoporosis stratification in resource-constrained environments
Osteoporosis is a chronic skeletal disorder characterized by progressive bone mineral density (BMD) loss and structural deterioration, significantly increasing fracture risk. Despite its high prevalen...
Retraction: [Pt(O,O’-acac)(γ-acac)(DMS)] Alters SH-SY5Y Cell Migration and Invasion by the Inhibition of Na+/H+ Exchanger Isoform 1 Occurring through a PKC-ε/ERK/mTOR Pathway
The incidence and risk factors of sepsis following ovarian cancer surgery: A retrospective Nationwide Inpatient Sample database study
Background Postoperative sepsis is a significant complication following ovarian cancer surgery. However, limited studies have explored the risk factors associated with postoperativ...
Engineering of T7 DNA-dependent RNA polymerase with activity at elevated temperature
Bacteriophage T7 RNA polymerase (T7 RNAP) is a key enzyme for in vitro transcription (IVT) and plays a central role in the production of synthetic mRNA for rese...
Assessing unprofessional behaviors of dental students through multi-source feedback: A mixed methods analysis of engagement and influencing factors
Background Unprofessional behaviors have been identified as a hindrance to the professional identity formation of dental students. This study aimed to investigate dental students’...
Parkinson’s disease and awareness of the passage of time: Perceived health, emotion, and self-transcendence
This study examined passage-of-time judgments in patients with Parkinson’s disease, compared to age-matched healthy controls. The aim was to determine whether these temporal judgments are influenced b...