PLoS ONE
Articles in this Issue
Integrative transcriptomic and metabolomic analyses provide insights into the mechanism of autotoxicity of Pugionium cornutum (L.) Gaertn
Pugionium cornutum (L.) Gaertn., a functional vegetable with dual health benefits, faces significant constraints in sustainable industrial development due to autotoxicity-induced continuous cropping o...
PRAME-AS lncRNA, regulated by MZF1, modulates PRAME expression and cell stemness
PRAME is a member of the large cancer-testis antigens (CTA). In normal tissues, PRAME is mainly expressed in the testis. However, low levels of PRAME transcript are detected in the endometrium, ovary,...
Triage and hospitalization outcomes in the geriatric population of an emergency department: A retrospective cohort study comparing the manchester triage system and the emergency severity index
Introduction Elderly patients in emergency departments (EDs) are at increased risk due to nonspecific symptoms, multimorbidity, and elevated mortality. This study compared the predictive performance o...
Biochemical description of ozonized propolis and its activity against pathogenic microorganisms, cancer cells, and inflammation with molecular docking interaction
Numerous experimental investigations conducted on different natural compounds; however, their effectiveness remains insufficient for overcoming the health problems. The effect of ozone on phytochemica...
Explaining solar forecasts with generative AI: A two-stage framework combining transformers and LLMs
Accurate and interpretable solar power forecasting is critical for effectively integrating Photo-Voltaic (PV) systems into modern energy infrastructure. This paper introduces a novel two-stage hybrid...
The Social Stress Indicator (SSI)
Social media shapes perceptions, influences emotions, and fuels anxieties, yet its true impact on social stress remains difficult to measure. This study introduces the Social Stress Indicator (SSI) as...
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration
Objective Acute Myeloid Leukemia (AML) is a heterogeneous disease with limited therapeutic options and poor prognosis for patients. Therefore, the aim of this study was to evaluate the potential value...
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Estimating the clinical and economic burden of medically attended influenza in South Korea, stratified by age and comorbidity: A five-season hospital-based surveillance data, 2014/15–2018/19
Objectives This study aims to estimate the clinical and economic burden of influenza in South Korea across five seasons (2014/15–2018/19), stratified by age and comorbidity, using data from the Hospit...
Tick saliva protein fraction inhibits breast cancer by decreasing cell viability and promoting apoptosis in vitro
Tick saliva contains protein and non-protein bioactive molecules with potential therapeutic applications, including anticancer properties. In this study, the effects of protein and non-protein fractio...
Application of group-based trajectory models to evaluate the association of fetal growth trajectories and childhood overweight and obesity: A longitudinal study with 2-year follow-up
Objective This study investigated whether fetal growth trajectory (FGT) can predict adverse childhood growth outcomes. The correlation between maternal metabolic factors (e.g., body mass index (BMI),...
Transcriptomic analysis implicates the involvement of RBM20 in Fuchs’ endothelial corneal dystrophy with TCF4 repeat expansion
Background Late-onset Fuchs’ endothelial corneal dystrophy (FECD) is a degenerative disease of cornea manifesting during the fourth decade of life or later. An intronic trinucleotide repeat expansion...
The impact of tumor microenvironment and treatment schedule on the effectiveness of radiation therapy
External Beam Radiation Therapy (EBRT) is predominantly administered using Conventionally Fractionated Radiotherapy (CFRT), that is 2 Gy per fraction. However, Moderately Hypofractionated Radiotherapy...
Iron-saturated bovine lactoferrin preserves microbiota diversity and healthy ageing-associated taxa in an in vitro colon model of elderly gut microbiota (Iron-saturated bovine lactoferrin impact on elderly gut microbiota)
Lactoferrin is a multifunctional milk protein receiving increased interest in recent years because of its potential as a functional food ingredient to reduce the prevalence of iron deficiency, while p...
Families with neurodevelopmental diagnoses are not ‘Hard to Reach’: Findings from a feasibility trial comparing parenting programmes for parents of children with ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) is defined by impairing levels of inattention and/or hyperactivity-impulsivity. It occurs in at least 5% of school age children and 2.5% of adults world...
Trends and disparities in Non-Hodgkin Lymphoma related mortality in the United States, 1999–2020
Background Non-Hodgkin Lymphoma (NHL) is the most prevalent hematological malignancy worldwide, making its mortality trends a critical public health concern. This study examines temporal trends in NHL...
Translocator protein (TSPO) analysis in saliva of adults with oral mucosal lesions: A preliminary study
Background The analysis of translocator protein (TSPO) in saliva could elucidate its potential role as biomarker in oral mucosal lesions associated to early-stage oral cancer. We compared the TSPO pro...
YOLO-based intelligent recognition system for hidden dangers at construction sites
To reduce the accident rate in the construction industry, an improved YOLOv5n-based hazard recognition system for construction sites is proposed. By incorporating optimization mechanisms such as the E...
Characteristics of self-motion sensation after major earthquakes: An internet survey
This study aimed to determine the characteristics and prognosis of new-onset swaying or dizziness, defined as self-motion sensation, following the 2024 Noto Peninsula earthquake in Japan and identify...
Differences in stiffness across the patellar tendon: An observational study using tendotonometry
Patellar tendinopathy is an injury with pain mostly located at the proximal region of the tendon and possibly related to changes in patellar tendon (PT) stiffness. However, little is known about the s...
Spatial attribution and policy design of rural entrepreneurship: Evidence from Anhui Province in China
Rural entrepreneurship is a key way to combat rural decline and promote the revitalization of rural areas and their sustainability, and also a key area of research in agricultural and rural geography,...
Chronic High Intensity Interval Training (HIIT) exercise in adolescent rats results in cocaine place aversion and ΔFosB induction
High-Intensity Interval Training (HIIT) is a form of exercise that has been greatly popularized over the past few years for its many health benefits. Similar to other forms of exercise, HIIT may be be...
DownLink amplified loss function module for 5G air to terrestrial communication networks
Combining air-to-ground network experiences with Fifth Generation (5G) communications, inferred path loss and Doppler impacts on communication dependability due to the difference in downlink sampling...
Disparities in multi-modal spatial access to primary and specialty care in U.S. neighborhoods: A cross-sectional and temporal analysis of health services
Spatial access to care describes the ability of populations to travel to healthcare providers. Existing spatial access to care studies frequently utilize metrics constructed using car-specific travel...
Predictive value of SOFA, PCT, Lactate, qSOFA and their combinations for mortality in patients with sepsis: A systematic review and meta-analysis
Background Sepsis is a leading cause of death, necessitating early prediction of mortality risk. Objective To systematically review the predictive efficacy of the Sequential Organ Failure Assessment...