PLoS ONE
Articles in this Issue
Adverse outcomes post-COVID-19 hospitalization among ESRD patients: A retrospective cohort study in 5 California university medical centers
Background Individuals with end-stage renal disease (ESRD) hospitalized for COVID-19 may have a higher risk for adverse post discharge events. To investigate these risks, we examined a large database...
Entomological survey to determine the role of cisterns in the production of Aedes aegypti in the U.S. Virgin Islands
Given the limited potable water supply in the U.S. Virgin Islands, most residents use cisterns to collect rainwater and store it for their daily needs. A survey conducted in 2019 found that 45.7% of t...
Spectrum of glucose-6-phosphate dehydrogenase (G6PD) mutations and trends in hemoglobin levels among adult dengue patients in Thailand
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans that may exacerbate clinical outcomes during viral infections such as dengue, particularly in regions where...
The effect of lifestyle intervention and depression symptoms on binge eating and relation of binge eating to gestational weight gain and child birth weight in the UPBEAT cohort of pregnant women living with obesity
Binge eating is one of the most prevalent eating disorder behaviours in pregnancy, its risk factors and association with pregnancy-related outcomes has sparsely researched in this population. This stu...
Exercise therapy to improve cervical proprioception in individuals with asymptomatic forward head posture: A systematic review of randomized controlled trials
Background Forward head posture (FHP) is a common musculoskeletal condition associated with impaired cervical proprioception, which compromises postural control and neuromuscular function. Exercise-ba...
From CBC to clarity: Interpretable detection of beta-thalassemia carriers in imbalanced datasets
Thalassemia is an inherited blood disorder and is among the five most prevalent birth-related complications, especially in Southeast Asia. Thalassemia is classified into two main types—alpha-thalassem...
CLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells
Cerebral ischemia–reperfusion injury (CIRI) occurs during the treatment of ischemic stroke when the affected blood vessels are recanalized and the oxygen supply to the brain is restored. Chloride intr...
In vitro and in vivo approaches demonstrating the antiproliferative activity of pomegranate seed proteins and peptides on breast cancer
Pomegranate seed proteins and peptides exhibit high antioxidant capacity according to previous work carried out by our group. The present work aims to evaluate the antitumoral potential of pomegranate...
Fetal malnutrition and associated factors among term newborn babies in Jimma Zone public hospitals, South West Ethiopia
Background Fetal malnutrition is a major public health burden affecting developing nations, potentially leading to cerebral and neurologic disabilities in later life. Despite its prevalence, little is...
Inhibition of LncRNA Kcnq1ot1 suppresses hypoxia-induced pyroptosis of H9C2 cells by regulating miR-27b-3p
Background Heart failure (HF) is a major cardiovascular disease with high mortality worldwide, whose pathophysiology is multifaceted. Hypoxia has emerged as a critical factor contributing to the progr...
Time-on-task estimation for tasks lasting hours spread over multiple days
The ability of a human to retrospectively estimate the amount of time spent on a task is largely only understood when the period of time is seconds- or minutes-long. The lack of research into estimati...
Validation of blue- and clear-native polyacrylamide gel electrophoresis protocols to characterize mitochondrial oxidative phosphorylation complexes
The mitochondrial oxidative phosphorylation (OXPHOS) system plays a pivotal role in the cell’s energy conversion. The enzymes involved in OXPHOS are arranged in five protein-lipid complexes. The first...
Prevalence of peripheral arterial disease and arterial calcification based on three ankle-brachial index calculation methods (highest, average, and lowest systolic ankle pressure): A cross-sectional study in Type 2 diabetes mellitus patients in Peru
Background Peripheral arterial disease (PAD) and arterial calcification (AC) are frequent yet underdiagnosed vascular complications in individuals with type 2 diabetes mellitus (T2DM). The ankle-brach...
The influence of teacher support on student engagement in physical education among college students: The mediating effects of autonomous motivation and self-efficacy
Student engagement is a malleable behavior shaped by instructional environments and widely regarded as a key component of higher education quality. Nevertheless, many college students have inadequate...
Assessment of glycemic control, health-related quality of life, and associated factors in type 2 diabetic patients attending a comprehensive specialized hospital in Northwest Ethiopia
Background Poor glycemic control in type 2 diabetes mellitus (T2DM) leads to serious complications that negatively impact health-related quality of life (HRQoL). This study aimed to assess glycemic co...
Cleavage of MALAT1 RNA by 14-nt sgRNA-guided tRNase ZL
We have been developing a gene suppression technology, tRNase Z L -utilizing efficacious (TRUE) gene silencing, in which artificially designed small guide RNA (...
Lactic acid regulates antitumor immunity in canine invasive urothelial carcinoma
Canine invasive urothelial carcinoma (iUC) is a fatal malignant neoplasm that closely resembles human muscle-invasive bladder cancer in terms of histopathological features, molecular alterations, and...
Reward network mechanism in anhedonia and depression
Background Depression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). Howe...
Robust emotion recognition for complex environments: ChildEmoNet model based on DETR-ResNet50 cascaded architecture
Emotion recognition faces significant challenges in complex real-world environments, particularly under facial occlusion conditions that severely impact traditional deep learning approaches. This rese...
Sugarcane stem node detection with algorithm based on improved YOLO11 channel pruning with small target enhancement
Sugarcane stem node detection is critical for monitoring sugarcane growth, enabling precision cutting, reducing spuriousness, and improving breeding for resistance to downfall. However, in complex fie...
The role of educational attainment and quality in U.S. regional variation in prevalence of dementia and CIND
There are striking disparities in dementia prevalence across regions of the U.S. Education is one of the most important risk factors for dementia. Level and quality of education varied geographically...
Molecular epidemiology and phylogenetics of camel anaplasmosis
Camel anaplasmosis is a tick-borne disease of zoonotic concern, yet its epidemiology in Pakistan remains understudied. This study aimed to determine the prevalence, associated risk factors, and phylog...
Efficiency analysis of 67 Chinese research universities considering inter-university heterogeneity: Evidence from a meta-frontier network SBM DEA model
With the continuous increase in technology research and development investment, the overall operational efficiency of universities as the main body of scientific research has always been a focus of re...
An improved FOX optimization algorithm using adaptive exploration and exploitation for global optimization
Optimization algorithms are essential for solving many real-world problems. However, challenges such as getting trapped in local minima and effectively balancing exploration and exploitation often lim...
Trends and projections of polycystic ovary syndrome burden in China: Insights from the Global Burden of Disease Study 2021
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age, associated with reproductive, metabolic, and psychological complications. In China, the b...