PLoS ONE
Articles in this Issue
Pre-infection cerebral cortex structure predicts murine sepsis outcome
Sepsis is a life-threatening condition caused by an inappropriate host response to an infection that can lead to multi-organ failure and death. Predictive markers that can inform the trajectory and ou...
Democratizing social media for health research: LLM-powered data analytics platform for NCDs
Despite over 41 million annual deaths from Non-Communicable Diseases (NCDs) globally, predominantly in low and middle-income countries, public access to relevant information from social media is hinde...
Diagnostic Reference Levels in pediatric interventional cardiology: A multicenter study by the French cohort in HARMONIC project
Background Pediatric interventional cardiology (IC) is an important diagnostic and therapeutic approach for addressing congenital heart disease (CHD) in children. However, the associated ionizing radi...
Effects of perceived instructional support and self-regulated learning support on students’ learning behavior in an online learning environment
Learning Analytics (LA) has advanced significantly in recent years; however, its findings often suffer from limited generalizability and transferability due to reliance on data from a small number of...
The relationship between agility and vertical jump performance in male handball players: A cross-sectional analysis on the role of developmental characteristics
Aim This research examines the relationship between agility and vertical jump by controlling for developmental characteristics (age, height, and body weight), which are important for sports performanc...
Integrative taxonomy of Cedrela (Meliaceae) leads to the recognition of a new species (C. tamaulipana) and the reinstatement of C. saxatilis
A new species of Cedrela (Meliaceae) is described and illustrated from recently discovered populations at Rancho del Cielo Biosphere Reserve, Tamaulipas, Mexico. The newly proposed species is morpholo...
Personalized education approach based on cognitive psychology for endoscopic diagnosis: A multicenter randomized trial
The learning curve for endoscopic diagnosis varies, and an optimal educational strategy is not available. Working memory (WM) refers to an individual’s ability to store and process information quickly...
Optimization of skeleton structure discrimination standard for SMA-13 mixture based on high-temperature performance
The stone–on–stone contact-interlocked skeleton structure of stone mastic asphalt (SMA) mixtures is crucial for the effective design of the mixture. However, existing skeleton structure discrimination...
A non-destructive evaluation strategy for surface weathering degree of limestone cultural relics in Zhejiang, China
In order to fully assess the protection of Limestone cultural relics from all forms of deterioration in Zhejiang Province, this study explored the relationship between the strength, longitudinal wave...
Development and application of chlorine-free antifreeze and dust suppression agent for transportation pavement of surface coal mines in Alpine areas
Truck transportation pathways in surface coal mining operations are significant sources of dust emissions. Currently, water sprinkling and aqueous dust suppressants are commonly used on haul roads in...
Association of CSF visinin-like protein 1 levels with cerebral glucose metabolism among older adults
Background CSF visinin-like protein 1 (VILIP-1) levels have exhibited potential utility as a marker of neuronal damage and are increased in Alzheimer’s disease (AD). The levels of CSF VILIP-1 have bee...
Correction: Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: A systematic review and meta-analysis
Canada’s 2025 AMR priority pathogens: Evidence-based ranking and public health implications
Background Antimicrobial resistance (AMR) is a growing global health threat that undermines the effectiveness of treatments and the sustainability of health systems. In 2015, Canada published its firs...
Correction: Epidemiological factors associated with Turtle fraservirus 1 (TFV1) in freshwater turtles in Florida, USA
Correction: Systemic immune-inflammation index is associated with clinical outcome of acute ischemic stroke patients after intravenous thrombolysis treatment
The timing of the Castelnovisation of southwestern Europe: A Bayesian modelling insight from the Romagnano Loc III rock shelter sequence (Trento, Italy)
This paper provides a review of the Mesolithic sequence at the Romagnano loc III site through Bayesian modelling, combining the radiocarbon dates obtained in the 1970s with more recent 14C dates. The...
A single PCR-sequencing method to establish the frequency of kdr alleles in the stable fly, Stomoxys calcitrans: application to seven livestock farms from south of France
The stable fly, Stomoxys calcitrans, is a cosmopolite pest causing direct and indirect nuisances on livestock, due to painful bite, harassment, blood despoliation and biological or mechanical transmis...
Exploring the implementation of an evidence-based health promotion intervention for women experiencing intimate partner violence (iHEAL) in diverse contexts: Study Protocol
Objectives This participatory, mixed methods study will explore how iHEAL, a woman-led, nurse-delivered health promotion intervention for women who have experienced intimate partner violence (IPV), ca...
Osmolality as a strong predictor of COVID-19 mortality and its possible links to other biomarkers
Osmolality, concentration of solute particles, was rarely used for prognosis for COVID-19. By analyzing blood samples of more than 1300 COVID-19 patients from Tokat, Turkey (including 100 surviving an...
Alternative splicing and residual function potentially expand the therapeutic landscape of the CFTRdele2ins182 variant
This study investigates the molecular and functional consequences of rare CFTR variants, particularly focusing on the complex allele [186-13C > G; 1898 + 3A > G] and the CFTRdele2ins182 rearrang...
Uncorrected refractive errors, visual impairment and need for spectacles among children and adolescents in eastern, China
Background Uncorrected refractive errors (URE) are the leading preventable cause of visual impairment (VI) in children globally, with China facing a critical dual challenge of high myopia prevalence a...
Optimized processing of Gardenia Fruits with ginger juice: Unveiling therapeutic mechanisms for cholestatic liver injury through TLR4/NF-κB, FXR/PPAR-α, and PI3K/AKT/GSK-3β
The study aimed to optimize the processing conditions of Gardeniae Fructus with ginger juice (GFPG) and confirm its therapeutic effects and pharmacological mechanisms on cholestatic liver injury. Proc...
Red cell distribution width (RDW) is independently associated with all-cause mortality in adult patients with osteomyelitis admitted to the intensive care unit
Objective This study aims to investigate the correlation between red cell distribution width (RDW) and overall mortality in adults diagnosed with osteomyelitis. Methods In this retrospective study,...
Effect of intermittent extracellular low-pH environment on human umbilical vein endothelial cell activity
Transcutaneous CO2 application promotes fracture healing and osteogenesis via angiogenesis. However, its molecular mechanism remains unclear. This therapy transiently decreases intra-tissue pH in the...
Experiences of adult children caring for parents aging in place
The rapid rise of the older adult population has increased the need for family caregiving. Adult children caring for their aging parents are exposed to a range of stressors, and their experiences shap...