PLoS ONE
Articles in this Issue
Evaluation of the performance of the Influenza-like Illness (ILI) surveillance system in the Okai Koi North District, Greater Accra Region, 2022
Background Influenza-like Illness (ILI) caused by the influenza virus, causes morbidity in Ghana. Records of ILI outbreaks in recent times and the COVID-19 pandemic disrupted surveillance activities,...
The impact of strategic alliances on corporate real investment and its mechanisms from the perspective of organizational learning theory: An empirical analysis based on Chinese listed companies
This study examines how firms enhance resource allocation efficiency and stimulate real investment through strategic alliances. The findings, based on data from Chinese A-share listed companies on the...
Hand hygiene after the COVID-19 pandemic: Is it still at a high level?
Background Hand hygiene (HH) is crucial for preventing healthcare-associated infections (HAIs), with compliance notably increasing during the COVID-19 pandemic. Whether this adherence can be sustained...
Impact of National health insurance on medication adherence among hypertensive patients: A hospital-based cross-sectional study from Kailali, Nepal
Introduction Noncompliance of medication among patients with chronic disease is a major challenge for the health system. Expanding of national health insurance among patients might increase their acce...
Can a noisy venue be bad for comedy?
People hear jokes live and pre-recorded in a variety of settings, from comedy clubs, bars, outdoor venues, cafes, to their own home or car. While a lot of research has analyzed the significance of the...
Perspectives of multidisciplinary healthcare providers in elderly daycare centres: Challenges, opportunities and impacts on geriatric care in Chiangrai Municipality, Thailand
The global surge in the ageing population has intensified pressure on healthcare delivery systems, leading to a heightened demand for elderly daycare services. This demographic shift necessitates inno...
Establishment and application of a dual real-time PCR assay for differential detection of PiAdV-1 and PiAdV-2 among pigeons in China in 2022–2023
Pigeon virus diarrhea is very common in the clinic, which has caused great damage to the pigeon industry. Pigeon adenovirus constitutes a significant pathogen responsible for pigeon viral diarrhea. Am...
Effect of Omega 3 supplementation during pregnancy and lactation on cognitive functions in rat offspring
Aim This study investigates the effects of omega-3 supplementation starting in the preconception period, during the 1st, 2nd, and 3rd weeks of pregnancy, and lactation on the cognitive functions of ra...
Enabling near real time use of wildlife necropsy data: Text-mining approaches to derive interactive dashboard displays
Manual review of necropsy records through close reading and collation is a time-consuming process, leading to delays in knowledge acquisition, communication of findings, and subsequent actions. Text-m...
CD44 as a novel therapeutic target in pulmonary arterial hypertension: Insights from multi-omics integration and molecular docking
Pulmonary arterial hypertension (PAH) is a progressive and often fatal disorder characterized by increased pulmonary vascular resistance and subsequent right heart failure. Inflammation plays a pivota...
Molecular basis for the activation of the bitter taste receptor TAS2R14 by Ritonavir
Ritonavir is a protease inhibitor used in combination with other antiretroviral drugs to treat HIV, especially in children. It enhances the effectiveness of these drugs by inhibiting the cytochrome P4...
Examination of unique volatile organic compound signatures in nasopharyngeal test swab viral transport media using an electronic nose
Rapid point of care tests for respiratory infections are associated with high rates of false negative results which can drive empiric, and potentially inappropriate, antibiotic use. Because infectious...
Study on the compaction characteristics of snow on airport runways under vertical load
Snow accumulation on airport runways reduces friction, affecting aircraft takeoff and landing performance, as well as operational efficiency and safety. Previous studies have primarily focused on the...
Acute radiation exposure in mice reveals traces of oxidation-mediated modifications in serum albumin
High doses of ionizing radiation induce specific oxidation-mediated modifications on the sequence of amino acid that constitutes serum albumin, but the time-dependent response thereafter is unclear. W...
Harambee! 2.0: Community resources and resilience factors to leverage for improving HIV testing behaviors among African immigrant communities in Seattle, Washington
Significant challenges promoting positive HIV testing behaviors among African immigrant communities in the U.S. persist, though existing community resources may be leveraged to improving these behavio...
Thiazole-carboxamide derivatives as potent antioxidant agents with drug-like properties: In vitro, molecular docking, and DFT studies
The search for novel therapeutic agents with potent antioxidant and antidiabetic properties remains a critical area of research in medicinal chemistry. Oxidative stress, caused by an imbalance between...
Low survival in younger adults with Acute Myeloid Leukemia (AML) in Tanzania linked to high disease burden and socioeconomic factors
Background Acute Myeloid Leukemia (AML) accounts for 20–25% of all leukemia diagnosed worldwide. According to Globoccan 2020, leukemia ranked the 15th most prevalent cancer with an estimated 474,519 n...
Production of recombinant human G protein-coupled estrogen receptor (GPER) and establishment of a ligand binding assay using graphene quantum dots (GQDs)
G protein-coupled estrogen receptor (GPER) is a member of the GPCR family and a key mediator of the rapid, nongenomic actions of estrogens as membrane estrogen receptors. In this study, we established...
Evaluation of QIAreach QuantiFERON-TB lateral-flow nanoparticle fluorescence assay for TB infection diagnosis among TB household contacts in three high-burden settings
Background Tuberculosis infection (TBI) testing, and treatment are fundamental to achieve TB elimination. TBI testing among close or household contacts (HHCs) has been limited, in part due to perceive...
Exploratory trajectory inference reveals convergent lineages for CD8 T cells in chronic LCMV infection
Trajectory inference refers to the task of reconstructing state sequences of dynamic processes from single-cell RNA sequencing (scRNAseq) data. This task frequently results in ambiguous results due to...
Can you learn not to respond to irrelevant motion while making fast arm movements?
If the target of a goal-directed arm movement is suddenly displaced, the movement is quickly adjusted in accordance with the target’s new position. Such quick adjustments are even observed if the targ...
Correction: Reconstructions of individual fish trophic geographies using isotopic analysis of eye-lens amino acids
Exploring the prevalence of severe obesity in a large teaching hospital
Background Obesity remains a critical public health issue in the Netherlands, where 50.2% of the population has a body mass index (BMI) over 25 kg/m2, 15.6% exceeds 30 kg/m2, and 3.5% meets the criter...
Risk prediction of all-cause mortality in hospitalized patients with severe acute pancreatitis by serum urea nitrogen/albumin ratio
Background Classification of risk levels in patients with acute pancreatitis remains a difficult task. Although some biomarkers have emerged to predict the prognosis of patients with acute pancreatiti...
Idiopathic hyperprolactinemia-associated hypogonadism in men presenting with normal testosterone levels
Purpose Hypogonadism, presenting with low libido, erectile dysfunction, and gynecomastia, frequently occurs in men with hyperprolactinemia, typically characterized by elevated serum prolactin, suppres...