PLoS ONE
Articles in this Issue
Gestational diabetes mellitus and its associated factors among women of advanced maternal age in Malaysia: Findings from a national survey
Gestational diabetes mellitus (GDM) is a growing public health concern, particularly among women with advanced maternal age. Understanding the prevalence and associated sociodemographic factors is cru...
Post-marketing safety of solriamfetol: A retrospective pharmacovigilance study based on the us food and drug administration adverse event reporting system
Purpose Excessive daytime sleepiness (EDS) seriously affects quality of life and may increase the risk of life-threatening situations, such as motor vehicle accidents. Solriamfetol is a novel medicati...
Investigating the coupling relationships of railway safety risks using the N-K model and complex network theory
To quantitatively analyze the coupling relationships between railway safety risk factors, identify key factors contributing to railway accidents, and develop scientific strategies for accident prevent...
The effect of a six-month programme of intradialytic cycling on survival and hospitalisations in people requiring haemodialysis: 5-year follow-up of the CYCLE-HD randomised controlled trial
We have previously shown that a six-month programme of intradialytic cycling (IDC) improved cardiovascular structure and function, it is unclear whether these changes are associated with long-term ben...
A machine learning framework for estimating the probability of blacklegged tick population establishment in eastern Canada using Earth observation data
Ixodes scapularis ticks are the primary vector of Lyme disease (LD) in North America, and their range has expanded into southeastern and southcentral Canada with climate change. This study presents a...
Harnessing interpretable novel combination of GloVe embedding with deep CNN-BiLSTM neural network for fake news detection
The important issue of fake news to society is how it affects how society runs in terms of decision-making and public perception. Hence, this study is a comparative analysis of innovative hybrid deep...
Recurrent venous thromboembolism and clot distribution in COVID-19 infection: A review by variant type
Research question Do PE distribution and rates of recurrent VTE differ between COVID-19 (CAPE) and non-COVID-19 (NCAPE) patients and among COVID-19 variants? Study design and methods A single-center...
Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture
Synthetic lethality describes a genetic relationship where the loss of two genes results in cell death, but the loss of one of those genes does not. Drugs used for precision oncology can exploit synth...
Speech-in-noise discriminability after noise exposure: Insights from a gerbil model of acoustic trauma
Speech comprehension, especially in the presence of background sounds, allegedly declines as a consequence of noise-induced hearing loss. However, the connection between noise overexposure and deterio...
Editorial Note: Incidence and predictors of HIV related opportunistic infections after initiation of highly active antiretroviral therapy at Ayder Referral Hospital, Mekelle, Ethiopia: A retrospective single centered cohort study
Comparative analysis of AI and expert evaluations in engineering design pedagogy
Background Integrating engineering design processes into science education has become a significant priority in STEM instruction. However, many science teachers face difficulties incorporating these p...
Retraction: Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX
Study on spray combustion characteristics of liquid ammonia/dimethyl ether dual fuel based on different injection strategies
Ammonia is a green zero-carbon fuel, yet its low reactivity poses challenges, including difficult ignition and slow combustion rates. Compared to diesel or biodiesel, dimethyl ether (DME) has no C-C b...
A fusion safety and security analysis framework for intelligent and connected vehicles
Driven by advancements in emerging technologies and data-driven innovations, the global automotive industry is focusing on intelligent and connected vehicles (ICVs), which involve complex electronic s...
Are videos uploaded by dental professionals on lip repositioning surgery of higher quality? A youtube video analysis
Lip repositioning surgery is a minimally invasive procedure used in the treatment of gummy smile. With the increasing demand for aesthetic dental procedures, platforms like YouTube™ have become popula...
Impact of middle leaders’ competencies on teachers’ technology acceptance in Malaysian TS25 schools
This study examines how middle leaders’ competencies influence teachers’ technology acceptance in Malaysian TS25 primary schools. The research combines the Middle Leaders’ Competency Model for Educati...
PDK1, associated with glycolytic metabolism, is a potential prognostic biomarker in osteosarcoma
The study explores the prognostic significance and therapeutic potential of 3-phosphoinositide dependent protein kinase-1 (PDK1) in osteosarcoma. Using bioinformatics analysis and experimental validat...
The influence of somatostatin analogues on the incidence of pancreatic fistulas and postoperative morbidity in patients undergoing pancreatic resection: A Bayesian network meta-analysis
Background Pancreatic resection is a critical treatment for pancreatic cancer and other pancreatic diseases. Somatostatin analogs are commonly used to prevent complications following pancreatic resect...
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial
Background Tasimelteon is a dual melatonin 1 and melatonin 2 receptor agonist. Tasimelteon is the first and only approved medicine to treat a circadian rhythm disorder. In this Phase III trial, the e...
Can flavoprotein monooxygenases functionalize long-chain n-alkanes?
Long-chain n-alkane functionalization is relevant for industrial and environmental applications, but it remains a significant challenge due to the inherent stability of their covalent bonds. Biocataly...
Magnitude of workplace violence and associated factors among healthcare professionals in East Africa: A systematic review and meta-analysis
Introduction Workplace violence refers to violent acts that occur in the workplace against employees while they are delivering services to consumers. This phenomenon is an invasive and alarming issue...
IFN-β therapy rescues dysregulated IFN-stimulated proteins, serum cytokines, and neurotrophic factors in multiple sclerosis: Multiplex analysis of short-term and long-term IFN responses
Introduction Dysfunctional regulatory T cells and subnormal responses to interferon-β disrupt the immune system in multiple sclerosis. We probed dysregulated type I IFN pathways in vitro and in vivo I...
Comparing efficacy and adherence of smartphone-guided exercises to conventional self-directed exercises for neck pain in office workers: A randomized controlled trial protocol
Background Self-exercises focusing on strength and endurance training, as well as self-mobilization, are effective in neck pain (NP). This study aims to investigate the differences in self-management...
End user experiences of an electronic health records platform in a tertiary hospital system in Kenya
Background Electronic Health Record (EHR) systems allow health care facilities to provide better care to patients and improve overall provider efficiency. They are vital for low-and middle-income coun...
Patient demographics, medical factors, treatment modalities and satisfaction at five traditional Chinese medicine practices in Switzerland: A cross-sectional study
Background Traditional Chinese Medicine (TCM) is increasingly integrated into healthcare and insurance systems, therefore, it is essential to understand its current status and patients’ perspectives....