PLoS ONE
Articles in this Issue
Development and validation of a machine learning-based predictive model for clinical remission in Crohn’s disease patients receiving Adalimumab therapy
Crohn’s disease (CD), a chronic inflammatory bowel disease, is witnessing a rising global incidence. Adalimumab (ADA), a biological agent, is widely used in its treatment. However, patients exhibit si...
Adaptive TreeHive: Ensemble of trees for enhancing imbalanced intrusion classification
Imbalanced intrusion classification is a complex and challenging task as there are few number of instances/intrusions generally considered as minority instances/intrusions in the imbalanced intrusion...
Defining a need for rapid response and practical guidance for recurrent and metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) management in France: A Delphi consensus
Background Recurrent and metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) presents substantial treatment challenges due to its aggressive and heterogeneous nature. While evidence-ba...
Healthcare providers’ perspectives of barriers and facilitators to highly active antiretroviral therapy adherence among HIV-positive women in Southern Ethiopia: A qualitative study
Background Following a strict regimen of highly active antiretroviral therapy (HAART) is the fundamental factor in achieving successful treatment outcomes for HIV/AIDS. Poor adherence to HAART not onl...
Luminance and thresholding limitations of virtual reality headsets for visual field testing
Purpose To investigate the luminance capacity and achievable threshold levels of commercially employed virtual reality (VR) devices for visual field testing. Methods This two-part study included (1)...
Comparative microfluidic and enzymatic analyses reveal multifaceted snake venom resistance and novel VWF behavior in the opossum Monodelphis domestica
Interactions between predators and prey are often characterized by strong selection pressures that shape extreme physiological adaptations. Venom resistance in large-bodied South American opossums (Cl...
The folklore of the “Swift” effect – lessons for medical research and clinical practice
Taylor Swift’s presence at National Football League (NFL) games was reported to have a causal effect on the performance of Travis Kelce and the Kansas City Chiefs. Critical examination of the supposed...
Religious values and confidence in science: Perceived tensions and common ground
While confidence in science is high compared to other institutions, many Americans question whether scientists share their values, including religious ones. Narratives surrounding science and religion...
Differences in access to water, sanitation, and hygiene facilities among residents of Korail Slum, Bangladesh, during normal vs. water-logging situations
Background Slum areas in Dhaka, Bangladesh, experience frequent water-logging after heavy rain. However, the extent to which access to water, sanitation, and hygiene (WASH) varies between normal vs. w...
What does it mean to have experienced the death of a relative in a context of social and funeral restrictions? Lessons from the pandemic for bereavement research and clinical practice
The circumstances of the Covid-19 pandemic raised concerns about their impact on people who were bereaved in this period. Numerous studies have attempted to quantify this impact. However, they have of...
S2DB-mmWave YOLOv8n: Multi-object detection for millimeter-wave radar using YOLOv8n with optimized multi-scale features
Millimeter-wave (mmWave) radar has become an important research direction in the field of object detection because of its characteristics of all-time, low cost, strong privacy and not affected by hars...
Exploring the relationship between built environment and multidimensional street market vitality: Insights from urban villages in Shenzhen using multi-source data
Street markets play a vital role in revitalizing cities, especially within urban villages, which are unique neighborhoods characterized by dense migrant populations and complex social dynamics. This s...
Mortality prediction for ICU patients with mental disorders using large language models ensemble and unstructured medical notes
Assessing mortality risk in the intensive care unit (ICU) is crucial for improving clinical outcomes and management strategies. Conventional artificial intelligence studies often neglect vital clinica...
Perinatal colonization with extended-spectrum beta-lactamase-producing and carbapenem-resistant gram-negative bacteria among home births in Bangladesh
Background Neonatal infections are increasingly caused by antibiotic-resistant bacteria. It is unknown to what extent home-based births, which account for nearly a third of deliveries in Bangladesh, m...
Unraveling the genomic complexity of secretion systems in the most virulent Xanthomonas arboricola pathovars
Xanthomonas arboricola pathovars pruni (Xap), juglandis (Xaj), and corylina (Xac) are phytopathogenic bacteria that infect Prunus spp., walnut, and hazelnut trees, respectively. In this study, the und...
The density of Braun’s Lipoprotein determines vesicle production in E. coli
Production of extracellular vesicles by Gram-negative bacteria is known to be associated with blebbing of the outer membrane. Several proteins within Gram-negative bacteria crosslink the outer membran...
Effects of alcohol consumption on the prevalence and incidence of non-alcoholic fatty liver disease: A systematic review and meta-analysis
Background and aims Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent diseases worldwide, with its prevalence and incidence continually increasing. However, the impact of alcohol c...
Support needs and adaptive behavior surveys: Services prediction and relationship
The Inventory for Client and Agency Planning (ICAP) and the Supports Intensity Scale (SIS) have been used to determine Medicaid eligibility for individuals with disabilities but are designed to captur...
Correction: Political participation among deaf youth in Great Britain
Anticholinergic burden and clinical outcomes among older adults admitted in a tertiary hospital: a prospective cohort study
Background Anticholinergic medication use is associated with adverse clinical outcomes, especially in older adults. However, few studies have assessed the anticholinergic burden in the Thai geriatric...
Knowledge, attitudes, and practice about protective ventilation among physical therapists
Objectives To measure knowledge, attitudes and practice (KAP) towards protective ventilation and identify factors associated with KAP among physical therapists in a country-wide survey. Methods We c...
Prevalence of dural puncture headache after caesarean section at a tertiary hospital in the Gambia
Background Following a caesarean section performed under spinal anaesthesia, a common complication is post-dural puncture headache (PDPH). Spinal anaesthesia has become the most common anaesthetic pro...
Efficacy and neural mechanism of acupuncture for essential hypertension: Study protocol for a randomized clinical trial
Background Hypertension is a major risk factor for cardiovascular diseases. Acupuncture has been used to control blood pressure in clinical, however, the high-quality clinical evidence is insufficient...
Relationship between diagnostic accuracy and self-confidence among medical students when using Google search: A mixed-method study
Background With the growing volume of medical information, proficiency in utilizing clinical decision support systems (CDSSs) is increasingly important for physicians. Further, research has primarily...
Exploring differences among serial, portfolio, and novice entrepreneurs: A study of demographic and psychological factors in micro and small enterprises
The aim of this study was to empirically validate selected demographic and psychological factors from Shane’s model in the context of serial and portfolio entrepreneurship. The analysis involved 326 e...