PLoS ONE
Articles in this Issue
Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells
Understanding the mechanisms that regulate cell identity acquisition and cell proliferation is crucial, not only for elucidating cellular functions but also for clarifying the pathogenesis of various...
Facing distortion: Impact of spatial distortions on upright and inverted face identification
Face identification is a critical activity of daily living that may be impaired by blur or distortions caused by vision loss or prosopometamorphopsia. In this study, we examine the face inversion effe...
Agro-morphological and molecular characterization of Amaranthus genotypes
Amaranth is a climate-resilient indigenous leafy vegetable that has the potential to contribute to global food security. Owing to its high protein, essential amino acid, mineral and vitamin contents,...
Experimental characterization and machine learning modeling of leakage-induced soil fluidization in water distribution systems
Leakage in water distribution systems poses a global challenge, not only due to resource loss but also through soil erosion and sinkhole formation, which risk infrastructure collapse. This study inves...
Morphological differences in populations of Jacobaea erucifolia: Genetic differentiation, phenotypic plasticity or ecotypes?
Accurate taxonomic classification is essential for effective conservation strategies, especially for rare and endangered species. Traditionally based on morphology, such classifications may be challen...
Correction: Vitamin D status in post-medieval Northern England: Insights from dental histology and enamel peptide analysis at Coach Lane, North Shields (AD 1711–1857)
How to achieve high-quality participation in voluntary environmental regulation: Influencing factors and decision mechanism
This paper aims to explore the influencing factors and their decision mechanism of high-quality participation in voluntary environmental regulation, so as to present an ideal situation of synergistic...
Genomic discovery of EF-24 targets unveils antitumorigenic mechanisms in leukemia cells
Curcumin, a polyphenolic compound derived from the plant Curcuma longa L., has demonstrated a wide range of therapeutic properties, including potential anticancer effects. However, its clinical effica...
Anaemia and associated factors in people living with HIV on ART in Southern Province of Zambia
Background Anaemia remains a significant comorbidity among people living with HIV (PLHIV) on antiretroviral therapy (ART) in Sub-Saharan Africa (SSA), exacerbated by biological, sociocultural, and cli...
Effectiveness of the capability approach in rehabilitation for persons with neuromuscular diseases: A controlled before-after study
Background Rehabilitation of persons with neuromuscular diseases (NMD) requires a personalised approach that focuses on achieving and maintaining a level of functioning that enables them to be in a st...
Influence of age and sex on the relative biological effectiveness of 13-keV/μm carbon ions for lifespan shortening of B6C3F1 Mice
Epidemiological studies of Japanese atomic bomb survivors indicate that the risk of cancer from radiation exposure is higher in individuals who are relatively young at the time of exposure, with women...
Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model
Age-related dysfunction in neuroendocrine signaling, which influences adipose tissue homeostasis, has been implicated in numerous diseases, including breast cancer. Caloric restriction has been shown...
Assessment of environmental risk factors for blastomycosis during a large outbreak at a Michigan paper mill
Background Blastomycosis is a rare, potentially fatal fungal infection caused by inhalation of Blastomyces spores, typically acquired outdoors in the midwestern and eastern United States. In 2023, the...
A protocol for an assessment of the health information system in Khomas region, Namibia
Introduction A robust and well-functioning Health Information System (HIS) is crucial for managing patient care, monitoring health system performance, and informing public health decisions. However, N...
Dual efficacy-toxicity of Chelidonii Herba in chronic obstructive pulmonary disease: Integrated network pharmacology, immune profiling and molecular docking
Objective To investigate the pharmacodynamic material basis, multi-target mechanisms of Chelidonii Herba in treating chronic obstructive pulmonary disease (COPD), and its hepatotoxicity pathways using...
Correction: Risk factors for, metrics of, and consequences of access to veterinary care for companion animals: A scoping review
Online assessment of medical students’ communication competence in patient encounters: Validation of the VA-MeCo situational judgement test
Background Medical communication is a core task of physicians, and its quality affects both patients and physicians. Hence, the teaching and measurement of medical communication competence (MCC) are c...
Motivation matters: How enrollment motives shape doctoral experiences and career aspirations
This study examines the motivational profiles of Russian doctoral students and their implications for academic success, satisfaction, and career aspirations. We employ data from a nationwide survey of...
An automated skeleton extraction method for 3D point-cloud phenotyping of Schima Superba seedlings
Aiming to address the issues of low efficiency and large errors in the manual measurement process of phenotypic parameters in Schima Superba seedlings, an automated non-destructive method for acquirin...
Loneliness is not associated with attention interference of negative social information: Evidence from four studies
Extended experiences of loneliness, defined as perceived social isolation, are associated with lasting impacts on health outcomes. One proposed mechanism through which loneliness contributes to health...
Sentiment analysis of classical Chinese literature: An unsupervised deep learning model with BERT and graph attention networks
Sentiment analysis has become a transformative technology in various contexts, particularly in Natural Language Processing (NLP), social media analytics, and literary analysis, as it can extract infor...
Multimodal data driven deep learning based seismic impedance inversion optimization
Seismic impedance inversion is a geophysical technique that transforms seismic data into quantitative subsurface properties, primarily acoustic impedance. This process enables the identification of ro...
Three-year outcomes of cystotomy for cystoid macular edema secondary to retinal vein occlusion
This retrospective observational study evaluated the three-year clinical outcomes of cystotomy for managing refractory cystoid macular edema (CME) secondary to retinal vein occlusion (RVO). A total of...
Volume kinetics of crystalloid and colloid solutions administered to healthy anesthetized cats
This prospective experimental study evaluated the disposition of a crystalloid and a colloid solution in 10 healthy cats under general anesthesia. Each cat was randomly assigned to receive either 20 m...
Caregiver mind-mindedness training as an early intervention for social anxiety in children: A protocol for a randomised controlled trial
Background This paper describes a randomised controlled trial (RCT) protocol aimed at investigating the efficacy of caregivers’ Mind-Mindedness training as an early intervention for preschoolers with...