PLoS ONE
Articles in this Issue
Efficacy of a volatile pyrethroid spatial emanator (SE) in reducing Anopheles host-seeking in outdoor kitchens in Southern Zambia
Introduction In southern Zambia, malaria transmission is low, with outdoor biting Anopheles mosquitoes playing a...
Accuracy assessment of three-dimensional abutment tooth data construction using swept-source optical coherence tomography
A limitation of widely used intraoral scanners (IOSs) is their inability to capture finish lines at the subgingival marginal area, as they only extract surface information. Swept-source optical cohere...
Depressive episode and treatment outcomes in elderly individuals with tuberculosis: A prospective cohort study in Korea
Background Depression is common in the elderly and has been linked with poor tuberculosis treatment outcomes. Methods...
Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes
Background Sodium–glucose cotransporter-2 (SGLT2) inhibitors are increasingly recommended as first-line treatment for type 2 diabetes mellitus (T2DM), but head-to-head data compari...
Associations between remote patient monitoring and uncontrolled blood pressure among patients diagnosed with hypertension: Exploring variations by race/ethnicity
Background Hypertension (HTN) is a critical public health concern that disproportionately impacts racial/ethnic minorities. The recent COVID-19 pandemic spurred rapid adoption of v...
Effect of foliar application of potassium on wheat tolerance to salt stress
Salinity stress severely hampers wheat productivity by impairing growth, photosynthesis, and metabolic balance. Potassium nutrition, however, can mitigate these effects by supporting physiological and...
Association of erythropoietin gene polymorphism (rs1617640 C>T/G) with diabetic retinopathy in Type 2 diabetes mellitus patients of Punjabi population in Pakistan
Diabetic retinopathy (DR) is a leading cause of vision loss in individuals with type 2 diabetes mellitus (T2DM) and is influenced by genetic factors. We investigated the association between the erythr...
Control techniques for creep deformation of surrounding rock in deep underground roadways
As resource extraction extends to greater depths, surrounding rock in deep underground roadways exhibits pronounced creep deformation due to the coupled effects of high in-situ stress and time-depende...
Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia
Cancer cachexia causes severe muscle wasting, and current treatments remain limited. Belt-type electrical muscle stimulation (bEMS) has emerged as a passive rehabilitation tool capable of activating m...
Complex crater formation by low energy impactors
We investigate the formation of complex craters in low-energy laboratory impacts using layered granular beds and a range of impactors, including solid, liquid, and granular types. Shallow granular tar...
Collagen composition in equine exuberant granulation tissue reflects tissue immaturity
Exuberant granulation tissue (EGT) is a second intention wound healing disorder. It commonly occurs in the distal limb of horses. EGT causes significant increase in the duration and cost of treatment,...
Detection and quantification of key dental pathogens through wastewater monitoring
Wastewater-based epidemiology (WBE) has been widely used to track viral pathogens like SARS-CoV-2 and polio, but its potential for monitoring common dental bacterial pathogens that infect the oral cav...
Enhanced random forest with geologically-informed feature optimization for complex volcanic rock lithology identification: A case study in the Wangfu Fault Depression, Songliao Basin
Identifying lithologies within the volcanic reservoirs of the Huoshiling Formation (Wangfu Fault Depression, Songliao Basin) remains challenging due to extreme heterogeneity, limited core control, and...
Identification of potential biomarkers and therapeutic targets for underactive bladder based on bioinformatics analysis and experimental validation
Underactive bladder (UAB) is a common disorder that significantly affects patients’ quality of life, necessitating the exploration of underlying molecular mechanisms for more effective management. Thi...
Broad-spectrum eye disease classification using a deep learning-based tailored software lens
The early and accurate classification of eye diseases is essential for preventing irreversible visual impairment. This task can be performed by deep learning approaches that automatically classify ret...
Bilateral vestibulopathy affects spatial and temporal perception
This study assessed impairments in spatial and temporal perception in individuals with bilateral vestibulopathy (BVP). A total of 30 BVP subjects and 35 healthy controls (CTL) participated in a series...
Safety and efficacy of an iBTA-induced autologous Biotube vascular graft and its preparation device BTM1 in below-the-knee bypass surgery for chronic limb threatening ischemia: A protocol for an open-label, single-arm, multicenter clinical trial
Purpose Chronic limb-threatening ischemia (CLTI) increases the risk of lower limb amputation if revascularization is not performed. The use of autologous venous conduits is the onl...
Moral violations lead to demeaning: Non-disclosure of HIV undermines perceived psychological needs
Dehumanization of stigmatized groups is a pressing social challenge, and to effectively address it, we must understand how it arises. Here, we identify social-cognitive antecedents of a subtle form of...
Effects of Vitamin E on Redox balance in regulating thiol/disulfide homeostasis in sepsis: An antioxidant therapy perspective
Background Sepsis, a life-threatening condition resulting from a dysregulated host response to infection, is associated with high mortality and remains a major global health burden...
Influence of body position on microcirculatory and autonomic responses during arterial occlusion in healthy adults
This study aimed to investigate how body position (supine, seated, and standing) influences post-occlusive reactive hyperemia (PORH) and autonomic nervous system activity, with implications for vascul...
Interpretable machine learning for cardiovascular risk prediction: Insights from NHANES dietary and health data
Background: Cardiovascular diseases (CVD) are one of the leading global causes of death, which requires an accurate early prediction. This study aimed to develop transparent machin...
Is air pollution negatively associated with physical fitness?—A cross-sectional study in 174,246 Chinese students
Objectives Air quality in China has become an increasing concern, its association with physical fitness remains unclear. This study represents one of the largest nationwide investi...
Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β– and α+/γ– transmembrane subunit interfaces of synaptic GABAA receptors
Background General anesthesia induced by etomidate, barbiturates and propofol is associated with positive modulation of synaptic αβγ GABA...
Spatial distribution and relative biomass of bigheaded carps in Lake Balaton, Hungary estimated from an environmental DNA survey
Silver carp ( Hypophthalmichthys nobilis ), bighead carp ( H. molitrix ) and their hybrids, collectively known as bighea...
Enhancing food security sustainability through digital information extension services in rural Uganda: Maize postharvest evidence-based strategies
Background Postharvest losses caused by poor drying and storage practices lead to maize waste, reduced food availability, unsafe food due to aflatoxin contamination, and income los...