PLoS ONE
Articles in this Issue
Editorial Note: Rising food prices and poverty in Pakistan
Bond market opening, monetary policy, and systemic financial risks – An empirical study based on the TVP-SV-VAR model
While the opening of the bond market provides strong support for high-level financial opening, it also accelerates the accumulation of systemic financial risks, thereby affecting the high-quality deve...
Metabolomics and databases driven approach of identification of phytochemicals from seed of Salvia schimperi using high-performance liquid chromatography tandem mass spectrometry
Salvia schimperi is widely used in Ethiopian folk medicine, particularly its raw and roasted seeds for treating ailments such as diarrhea. While numerous reports on its traditional...
A Fragmentation behavior-guided UHPLC-Q-Orbitrap HRMS method for the quantitative analysis of 26 perfluoroalkyl substances and their alternatives in water
Perfluoroalkyl substances (PFASs), including newly introduced alternatives, are of global concern due to their environmental persistence, bioaccumulation, and potential health risks. We developed and...
Naturalistic sleep tracking in a longitudinal cohort: Uncertainty and bias in short duration sampling
Background Despite broad interest in the health implications of sleep duration, traditional measurements via polysomnography or actigraphy are often limited to one or a few nights...
A neural network approach to sarcopenia prediction based on bioelectrical impedance in community-dwelling older adults
This study aimed to apply a neural network to raw bioelectrical impedance analysis data and to test whether sarcopenia could be predicted with high accuracy. The study population comprised 727 communi...
Correction: Diabetes rescue, engagement, and management (D-REM) for hypoglycemia: Clinical trial protocol of a community paramedic program to improve diabetes management among adults with severe hypoglycemia
Stability analysis of heterogeneous oligopoly games of increasing players: A computational approach
In this paper, we study an oligopolistic market endowed with an isoelastic demand function and a quadratic cost function, where heterogeneous firms coexist and produce the same product. We create new...
Diagnosis of colorectal cancer using residual transformer with mixed attention and explainable AI
Colorectal cancer (CRC) is the leading cause of cancer disease and poses a significant threat to global health. Although deep learning models have been utilized to accurately diagnose CRC, they still...
Correction: Evaluating the long-term strength of GGBFS-blended cement across various water-to-binder and superplasticizer ratios under heating/cooling cycles
Correction: Assessing the feasibility of large language models to identify top research priorities in enhanced external counterpulsation
Association between obesity and psychological distress in the Chilean population during the COVID-19 pandemic: Social Wellbeing Survey 2021
The COVID-19 pandemic has exacerbated obesity and mental health problems, particularly anxiety and depression. Both conditions share common risk factors, suggesting a possible bidirectional relationsh...
Resampling methods for class imbalance in clinical prediction models: A scoping review protocol
Introduction Class imbalance—where clinically important “positive” cases make up less than 30% of the dataset—systematically reduces the sensitivity and fairness of medical predict...
Designing interventions to scaffold emotional awareness, beliefs and action tendencies
I demonstrate – via a novel intervention comprising evaluation of emotional contrasting cases and expressive writing – improvements in emotional awareness, beliefs and action tendencies among lower se...
Comparison of volumetric responses to different corticosteroid administration methods in IgG4-related ophthalmic disease
Purpose To analyze the clinical and volumetric responses to different corticosteroid administration methods for IgG4-related ophthalmic disease (IgG4-ROD)....
In silico identification, high yielding isolation and in vitro validation of 6β-cinnamoyl-7β -hydroxyvouacapen – 5α - ol as a Wnt/β-catenin pathway targeted anti-cancer secondary metabolite of Caesalpinia pulcherrima
Wnt/β-catenin signaling pathway is frequently dysregulated in cancer stem cells (CSCs), a sub population of cancer cell mass that drives tumor proliferation, metastasis, recurrence, and chemoresistanc...
Investigation of accessory navicular in local pre-adolescence children: A longitudinal study with 2-year follow-up—KID Locomo Study
Introduction The accessory navicular (AN) is an accessory ossicle located on the medial side of the navicular bone and is often associated with sports-related overuse injuries duri...
Opening up? Exploring motives and needs of students and staff of a Dutch university on disclosing mental health issues to inform decision aid development
Background Decisions about disclosing mental health issues can be difficult, especially in the university setting. For this reason, students and staff of universities might benefit...
Aging influences nucleolar responses to traumatic brain injury in Drosophila
Traumatic brain injury (TBI) affects millions of people globally each year, yet effective treatments remain limited. A major challenge is the complexity of cellular and molecular responses to brain in...
Impact of imperceptible motion delay in avatar head movement away from a target on preference formation
This study investigated the effect of imperceptible motion delay in avatar head movements on preference formation among operators. Despite the growing importance of avatars in various applications, th...
What matters most to older adults in treatment decision making: A discrete choice experiment
Introduction Medical decision making is often guided bydisease-specific outcomes such as life extension or survival. Especially for older adults other outcomes like maintaining ind...
Retraction: The PI3K/AKT/mTOR Signaling Pathway Is Overactivated in Primary Aldosteronism
Investigating multimorbidity patterns and associated risk factors in the fasa adults cohort study (FACS): A latent class analysis
Background Multimorbidity, defined as the co-occurrence of multiple health conditions, is a major global public health concern. This study aimed to identify latent classes of multi...
Combined effect of nutritional inflammation as well as depression on mortality in middle-aged and elderly people with osteoporosis and osteopenia
Background Inflammation, nutritional status, and depression interact complexly, impacting health outcomes. This study investigates their associations with all-cause and cardiovascu...
Reimagining cultural heritage conservation through VR, metaverse, and digital twins: An AI and blockchain-based framework
Recent advances in artificial intelligence (AI), blockchain, virtual reality (VR), and digital twin technologies are transforming approaches to cultural heritage conservation. This study develops an i...