PLoS ONE
Articles in this Issue
Exploring healthcare staff experiences with a hybrid paper/digital health management information system and their perspectives on digitalization as an alternative – A Tanzanian qualitative case study on perinatal data
Quality health data is essential to improve delivery and outcomes of healthcare. This study explores the experiences of healthcare staff in Kilimanjaro, Tanzania, using a hybrid paper and digital Heal...
Methodological approach to optimize a step-by-step deterministic linkage of SNDS data with a clinical database (FREGAT) of gastric/gastroesophageal junction adenocarcinoma in France: Pitfalls and learnings
Purpose Survival rates in the European population with gastric and gastroesophageal junction (G/GEJ) adenocarcinoma remain low. Epidemiologic research is warranted to understand th...
Enzymatic properties of a L-asparaginase without secondary glutaminase activity from Streptomyces scabrisporus
Acute lymphocytic leukemia (ALL) is characterized by the uncontrolled proliferation of lymphocyte precursor cells within the bone marrow, blood and extramedullary sites. L-asparaginase has become a st...
Assessing the Longitudinal outcomes of Piperacillin/tazobactam versus ceftriAxone and metronidazole for Children with perforated Appendicitis (ALPACA): A protocol for a pilot randomized controlled trial
Background Acute appendicitis is the most common indication for emergency surgery in children. In cases of perforation, patients require post-operative intravenous antibiotics in h...
Enhanced surface plasmon resonance biosensor with graphene-black phosphorus heterostructure for ultra-high sensitivity refractive index detection with machine learning for behaviour prediction
This study reports a five-layer surface plasmon resonance biosensor architecture comprising a BK7 glass substrate, silver plasmonic film, monolayer graphene, black phosphorus dielectric, and analyte r...
Smoking cessation counseling practices in Jordan: Using the trans-theoretical model
The trans-theoretical model of behavior change (TTM) is widely used to assess an individual’s readiness to perform the new behavior and categorizes the behavior change into five stages: “pre-contempla...
Reduced mortality but elevated venous thromboembolism risk following knee and hip arthroplasty in patients with rheumatoid arthritis: A general population-based cohort study
Arthroplasty is indicated for patients with rheumatoid arthritis (RA) who experience significant joint damage, including bone erosions, cartilage degradation and joint deformities. However, studies on...
Graph neural networks for integrated information and major complex estimation
This study investigates the potential of graph neural networks (GNNs) for estimating system-level integrated information and major complex in integrated information theory (IIT) 3.0. Owing to the hier...
Impact of outer width of the metacarpal diaphysis on the identification of low bone mass in children
Developing a strong skeleton during growth is critical for minimizing fractures later in life. Prior work showed that bone mass varied with external bone size, a measure of the outer bone width. We te...
Enhancing pragmatic competence in Kurdish EFL learners: The impact of a learner-centered approach
The study investigates how a learner-centered learning approach (LCL) can help raise pragmatic competence in Kurdish learners of English as a foreign language (EFL). Pragmatic competence in using lang...
Effects of exercise modalities on heart rate recovery and its association with cardiometabolic risk in adolescents with overweight or obesity
Objective Attenuated heart rate recovery (HRR) immediately after exercise is an independent predictor of cardiovascular disease and mortality in adults. We examined the effects of...
Relation between motor competence and academic achievement: The mediating role of fitness and cognition in boys and girls
Introduction Gross motor competence is positively associated with academic achievement in schoolchildren, potentially mediated by fitness and cognition. However, the extent to whic...
Efficient subcarrier allocation for smart grid communications in neighborhood area networks
This paper introduces the Adaptive Hierarchical Multi-Objective Resource Optimizer (AH-MORO), a ground-breaking framework for subcarrier allocation in Smart Grid Neighborhood Area Networks (NANs), add...
Relationship of the metabolic score for insulin resistance and the new-onset hypertension: Evidence from CHARLS
Background Hypertension (HTN) progression is linked to insulin resistance (IR), yet the association between Metabolic Score for Insulin Resistance (METS-IR) and HTN remains underex...
Testing a bat fatality detection system at wind turbines
To understand conditions associated with bat fatalities at wind turbines for informing reduction strategies, researchers began using thermal camera video monitoring with a field of view (FOV) focused...
Teachers’ experiences of delivering youth vaping prevention materials in schools in England and Scotland: A cross-sectional online survey
INTENT is an evidence-based smoking prevention programme for secondary school pupils in Great Britain (GB) that was recently expanded to include vaping information. Little research has evaluated GB-sp...
Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology
Any strategy that can selectively and persistently lower the brain levels of the cellular prion protein (PrP C ) is expected to extend survival in prion disease...
Mechanistic insights into excitonic and electrostatic stimulation of cells by photovoltaic substrates/nanocrystals and through light polarization modulation
Photoelectrical stimulation of cells and neural modulation via the separation of photo-induced electrical charges in photocapacitor structures have proven effective and biocompatible for therapeutic a...
Geometric modelling of 3D pore space using curve skeleton: Application to computational microbiology of soil organic matter mineralization
Recent advances in 3D X-ray Computed Tomography (CT) sensors have stimulated research efforts to unveil the extremely complex micro-scale processes that control the activity of soil microorganisms. Cl...
Sleep deprivation disrupts diurnal rhythmicity of gut microbiota and blood inflammatory cytokines in mice
Background Disruption of diurnal rhythms can lead to various diseases in humans and animals. There is an interaction between the diurnal rhythms of host and gut microbiota. This st...
Study on fracture of coal samples with different fracture angles under microbial environment
To investigate the permeability enhancement effect of microorganisms (Methanogens) on anthracite and their impact on coal strength, static fracture tests were conducted on semi-circular SCB specimens...
Variant patterns and influence of inter-regional travel during the SARS-CoV-2 expansion in South Africa
We evaluated the dynamic impacts of three types of human mobilities—provincial inflows, cross-district flows, and within-district flows—on daily reported COVID-19 cases for 2020. Using a structural eq...
Feasibility and acceptability of gamified cycling exercise for residents in a long-term care home: A qualitative study
Gamification can motivate older adults to exercise by transforming physical activities into enjoyable experiences. Incorporating gaming elements in cycling exercises can foster a sense of interest and...
Psychosocial and cognitive predictors of academic achievement among higher education students in Southern Ethiopia
Introduction Academic achievement is influenced by a combination of personal cognitive abilities, psycho-social resources, and educational context. Core cognitive functions such as...
From acute injury to chronic comorbidity: Interrupted time series modeling of traumatic brain injury impact among post-9/11 veterans
Traumatic brain injury (TBI) is associated with a variety of adverse health outcomes that display complex behavior over time. The objective of this study was to investigate both the early and late hea...