PLoS ONE
Articles in this Issue
Multi-scale dynamic graph neural network for PM2.5 concentration prediction in regional station cluster
Accurate prediction of PM2.5 concentrations is crucial for public health and environmental management. However, effectively capturing complex spatiotemporal dependencies across multiple time scales re...
Establishment and culture of mouse oviductal organoids and isolation and characterization of their secreted extracellular vesicles
Oviductal (fallopian tube) cell cultures are widely used to improve understanding of oviductal pathophysiology and to improve sperm and embryo quality via co-culture. One type of oviductal cell cultur...
Seasonal climatic niche-switching migration in the Nearctic-Neotropical Rufous Hummingbird (Selasphorus rufus)
Migratory birds inhabit diverse geographic regions during their reproductive and wintering periods; however, information regarding the climatic conditions that enable migratory birds, particularly hum...
Personal identification via matching of curved multiplanar computed tomography reconstructions and panoramic radiographs
Computer vision (CV)-based personal identification enables automated matching of recent radiological images with clinical databases to identify unknown individuals. This study aimed to assess whether...
Risk of cardiovascular disease and death in patients with breast cancer receiving anthracycline-based therapy: A retrospective cohort study
Background With the increasing survival rate and overall lifespan of patients with breast cancer, increased mortality due to cardiovascular causes is a notable concern. Anthracycli...
Perspectives of racially minoritized youth with disabilities on addressing ableism and other forms of discrimination
Background Racially minoritized youth with disabilities often encounter more extensive forms of discrimination. However, little is known about youth perspectives for addressing dis...
Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways
Background Hypercholesterolemia remains a key risk factor for atherosclerotic cardiovascular disease (CVD). The clearance of low-density lipoprotein (LDL) particles from plasma, pr...
Development and validation of the healthcare provider and family bidirectional digital communication scale
Introduction Effective communication between healthcare providers and families is critical in ICUs, yet existing assessment scales predominantly focus on unidirectional, face-to-fa...
Measuring geographic proximity and continuity with family medicine at end-of-life: Protocol for a population-level retrospective cohort study using Canadian Health Administrative Data
Background Family physicians play an important role in coordinating care for medically complex patients, especially during the end-of-life (EOL) period. While continuity of care (C...
Design and experimental study of a precision fluid hill-drop planter for maize
The study presents the design of a precision maize hill-drop dibbler based on fluid control and zero-speed seeding theory, developed to overcome challenges of poor planting precision, seed damage, lim...
Proinflammatory gene and protein expression alterations in human limbal aniridia fibroblasts
Aniridia-associated keratopathy (AAK) results from the paired box 6 (PAX6) gene haploinsufficiency, leading to depletion of limbal epithelial stem cells, persistent inflammation and a gradual loss of...
Experimental study on water-heat-salt migration and deformation characteristics of subgrade filler during freeze-thaw cycles in Northwestern China
The seasonal freeze-thaw action of saline soils in Northwestern China deteriorates embankment material properties, thereby adversely affecting train ride comfort and increasing railway maintenance exp...
Determination of appropriate time for establishing a model of postmenopausal osteoporosis induced by bilateral oophorectomy: From bibliometric analysis to animal experiment
Objective This study aimed to investigate the optimal age for developing a model of postmenopausal osteoporosis via bilateral oophorectomy. Moreover, the timing and effectiveness o...
Sugar-sweetened beverage/snack consumption and its determinants among infant and young children aged 6–23 months in twelve Sub-Saharan African countries: Evidence from 2019–2023 Demographic Health Survey data
Background Sugar-sweetened beverages or snacks are limited in nutritional value. Excess consumption of sugar-sweetened beverages or snacks in early childhood is associated with ina...
Multi-locus phylogenetic network analysis of Ampelomyces mycoparasites isolated from diverse powdery mildews in Australia and the generation of two de novo genome assemblies
The interactions between powdery mildews ( Ascomycota , Erysiphaceae ), obligate biotrophic pathogens of many plants, an...
Correction: Anti-staphylococcal activity, antibiotic-resistance modulation effects and action of Harungana madagascariensis (Hypericaceae) fruit extracts on the antioxidant system of multidrug-resistant Staphylococcus aureus
Identification and validation of palmitoylation-related signature genes based on machine learning for prostate cancer
Prostate cancer (PCa) remains a leading cause of cancer-related mortality in men, with challenges in diagnosis and treatment due to tumor heterogeneity. This study identifies palmitoylation-related si...
Elevated blood urea nitrogen-to-creatinine ratio predicts short-term mortality in intensive care unit patients with ischemic stroke: Evidence from a multicenter cohort
Background The blood urea nitrogen-to-creatinine ratio (BUCR) has emerged as a potential biomarker for predicting the prognosis of Intensive Care Unit (ICU) patients. However, its...
The association between the C-reactive protein-triglyceride-glucose index and cardiovascular diseases: A cohort study using data from the China Health and Retirement Longitudinal Study 2011–2020
Background Inflammation and insulin resistance (IR) are both risk factors for cardiovascular disease (CVD). The C-reactive protein-triglyceride-glucose index (CTI) is a novel bioma...
The ex vivo effects of ethanolic extractions of black cumin seed, turmeric root, and Ceylon cinnamon bark on the human gut microbiota
Black cumin, turmeric root, and Ceylon cinnamon bark are spices that have been used for both culinary purposes and in traditional medicine practices. These spices are frequently connected with providi...
Depressive symptoms and healthcare utilization among older adults in China: A cross-sectional examination of the national CHARLS data guided by Andersen behavioral model
Background With global population ageing, the mental health of older adults is a significant public health concern. Depression and depressive symptoms are increasingly prevalent an...
Analysis of the distraction impact on driving performance across driving styles: A driving simulator study in various speed conditions
Distracted driving is a mounting global issue, prompting numerous naturalistic and simulator-based investigations. This study investigates the impact of hands-free (HF) conversation and texting distra...
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda
Mutations in rpoB , a gene that encodes the bacterial RNA polymerase (RNAP) beta-subunit, can cause high-level resistance to rifampicin. Approximately 95% of ri...
Effect of zinc oxide nanoparticles (nZnO) on antioxidant defense, lignin metabolism and cadmium subcellular distribution in lettuce (Lactuca sativa L) under low-dose cadmium stress (hormesis)
Most studies on cadmium (Cd) have focused on its toxicity at high concentrations, while its hormetic effects at low doses remain underexplored. Lettuce ( Lactuca sativa...
Advances in deep reinforcement learning enable better predictions of human behavior in time-continuous tasks
Humans have to respond to everyday tasks with goal-directed actions in complex and time-continuous environments. However, modeling human behavior in such environments has been challenging. Deep Q-netw...