PLoS ONE
Articles in this Issue
Motion analysis and structural parameter optimization for nested multi-link transplanting mechanism of variable plant spacing transplanting machine
The nested multi-link transplanting mechanism features a compact structure suitable for transplanting machines and enables zero-speed transplanting, which is crucial for high-quality seedling establis...
Evaluation of umbilical cord blood serum eye drops for severe dry eye in two distinct populations—Sjögren’s syndrome and mustard gas–induced ocular injury: Protocol for a pilot randomized clinical trial
Background Human umbilical cord blood (HUCB) serum eye drops contain growth factors, neurotrophic agents, and antimicrobial compounds that may promote ocular surface healing and re...
Association between average triglyceride glucose-body mass index and risk of hypertension in middle-aged and elderly Chinese: A study based on Chinese CHARLS cohort data
Objective This study aimed to investigate the relationship between cumulative average triglyceride glucose-body mass index (TyG-BMI) and the risk of developing hypertension among m...
Exosomes from bone marrow mesenchymal stem cells protect melanocytes under vitiligo-related conditions through induction of NRF2/HO1 expression
Background Vitiligo, a chronic autoimmune disease linked to excess oxidative stress, can be temporarily improved. Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSCs...
Comparative effectiveness of adjuvant treatment for hepatocellular carcinoma with high risk of recurrence: A systematic review and network meta-analysis
Objective To identify the most effective postoperative intervention regimen for persons with hepatocellular carcinoma (HCC) at high risk of recurrence....
Implementation and staff perceptions of a quality assurance system in a Finnish private hospital during the COVID-19 Pandemic: A qualitative study
Background Implementing quality assurance systems in healthcare settings is a growing trend globally. However, the impact of such systems on staff well-being and patient safety, pa...
Who gets included? A scoping review protocol of digital health interventions for older adults with heart failure through an equity lens
Introduction Heart failure is a common and progressive condition that significantly impacts older adults, leading to increased morbidity, reduced quality of life, and healthcare ut...
Effects of music intervention on golf-specific skill performance of golfers under mental fatigue: Protocol for a randomized controlled trial
Given that golf tournaments last approximately five hours without an intermission, mental fatigue has become a critical factor affecting performance. Although research has shown that music interventio...
Housing environment bilaterally alters transcriptomic profile in the rat hippocampal CA1 region
Brain asymmetry is a fundamental feature of neural organization. However, the molecular basis of hippocampal lateralization in response to environmental stimuli remains poorly understood. Here, we exa...
The impossible confounder: Quantifying the limits of alternative explanations for COVID-19 vaccine effectiveness
Background Observational studies have consistently reported large reductions in COVID-19 risk among vaccinated individuals. However, critics have raised concerns that unmeasured co...
SARS-CoV-2 detection is independent of microbiome composition on surfaces in a major Ontario hospital
The SARS-CoV-2 pandemic has resulted in considerable mortality in hospital settings. Built environment surveillance can provide a non-invasive indicator of SARS-CoV-2 status in hospitals, but we have...
Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids
Background Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with limited therapeutic advancements and rapid development of treatment resistance. Fatty acid...
The moderating role of father involvement in the association between maternal depression and child nutrition: A cross-sectional study in rural Malawi
This study highlights the critical role of fathers in improving child dietary diversity in low-resource setting, particularly in the context of maternal mental health challenges. Using cross-sectional...
Forage preference in two geographically co-occurring fungus gardening ants: A dietary DNA approach
Traditional methods of forage identification are impractical with non-leafcutting fungus gardening ants, making diet-related ecological and life history questions difficult to study. To address this l...
Thyroarytenoid muscle fiber orientation regulates the ability to modulate vocal fold vertical thickness
While all speakers modulate their voice quality, some speakers do so more easily than others. Previous studies suggest that the ability to modulate voice quality depends on the ability to control voca...
Rootstock effects on floral induction in commercial Iranian almond cultivars: Insights from morphophysiological, biochemical, and molecular analyses
Orchard productivity in almond trees is strongly influenced by rootstock selection, which plays a key role in floral induction and yield optimization. Although several rootstocks are commonly used in...
Brain tumour segmentation in fused MRI-PET images with permutate U-Net framework
Brain tumor segmentation from MRI’s and PET has always been a challenging and time-consuming phase for radiologists, due to low sensitivity boundary region pixels in this image modality. Deep learning...
Dung beetle assemblage changes along a chronosequence in a recovering tropical dry forest
Tropical dry forests are among the most threatened ecosystems globally, facing extensive degradation from land-use change. Understanding how biodiversity responds during forest regeneration is critica...
microRNA-184 distribution and consequences on glial septate junctions and the blood-brain barrier
Cellular permeability barriers restrict the diffusion of solutes, pathogens, and cells across tissues. In Drosophila melanogaster , septate and tricellular junc...
Preeclampsia, prevalence and associated factors
Background Preeclampsia (PE) is a significant obstetric complication associated with adverse maternal and fetal outcomes. Zambia, like several Sub-Saharan African nations, experien...
Genome-wide identification and comparative analysis of strigolactone biosynthetic genes in major solanaceous crops
Strigolactones (SLs) are a class of important plant hormones that not only regulate plant growth and development but also mediate responses to biotic and abiotic stresses. Functioning as signaling mol...
Hydration product phase evolution and mortar strength development in alkali-activated slag and fly ash systems
Alkali-activated geopolymer materials, derived predominantly from industrial byproducts such as fly ash and slag, represent a sustainable alternative to Portland cement for applications including anti...
Correction: Effect of a loss of the mda5/ifih1 gene on the antiviral resistance in a Chinook salmon Oncorhynchus tshawytscha cell line
LA-ICP-MS Zircon U-Pb Ages, geochemical characteristics, and geological significance of the early cretaceous volcanic rocks in Haitangwan Town, Southern Hainan Island, China
The Lumuwang Formation in Hainan Island is a key stratum for analyzing Mesozoic tectonic evolution. However, its depositional age relies only on sporopollen evidence, lacks high-precision dating, and...
Capsule-based federated reinforcement learning adaptive sliding mode for anomaly detection and control of floating wind turbines
Floating wind turbines (FWTs) are now recognized as one of the most effective and affordable renewable energy sources. However, their performance is strongly influenced by dynamic environmental condit...