PLoS ONE
Articles in this Issue
KerSpecGen: Co-piloting formal Kernel specification synthesis with refined knowledge graphs and large language models
Formal verification ensures software correctness but faces challenges in kernel specification writing, which is labor-intensive, expertise-dependent, and limited to specific targets. For complex micro...
Impacts of continuing education for health professionals in primary health care: A scoping review
Introduction Continuing Health Education (CHE) is an essential strategy for the continuous qualification of Primary Health Care (PHC) professionals, promoting knowledge updating an...
Extraction of driving behavior primitives considering driver expectation and vehicle dynamics
Extracting meaningful driving behavior primitives is crucial for fine-grained behavior analysis. To develop primitives that more closely mirror the hierarchical nature of human driving, this paper int...
Using Sentinel-1 satellite imagery to quantify oil palm cultivation: A case study from Cameroon
Tropical deforestation is increasing globally, putting forest ecosystems and the ecosystem services they provide at risk. The widespread use of palm oil in fast food, cosmetics, household cleaners, an...
Analysis of bearing mechanism of large-diameter under-reamed piles based on model tests
Given the insufficient understanding of the bearing mechanism and failure modes of large-diameter under-reamed piles in complex strata, this study conducted scaled laboratory model tests based on simi...
Robust deepfake detector against deep image watermarking
Deepfake technology poses a significant threat to information security,rendering deepfake detection research crucial. However, current detection methods experience a marked performance degradation in...
Determination of the P-T conditions and depths of magma storage zones for two distinct quaternary lava flows in the Southeast of Mount Ağrı (Eastern Anatolia, Turkey)
This study aims to determine the pressure (P)-temperature (T) conditions and depths of magma storage zones for two distinct lava flows located to the southeast of Mount Ağrı (5137 m), the highest stra...
The impact of Pasifikas in Medicine on Pacific Islander medical student experiences
Background Pacific Islanders experience significant health disparities. One contributing aspect to these disparities is the lack of racial concordance as Pacific Islanders are unde...
Systematic analysis of spontaneous tandem genome amplification events in Yersinia pestis
Tandem amplification of genomic fragments is quite common in bacteria growing under stress conditions, while spontaneous genome amplification events are rare, unstable and generally poorly described....
Food insecurity, food assistance, and physical and cognitive functioning among older Americans
Introduction Food insecurity is associated with adverse late-life health outcomes, including disability, dementia, and mortality. But its role in changes in physical and cognitive...
Trigonometric function transformation and its application in software reliability modeling
Context: Many models based on S-shaped functions demonstrate their advantages in non-homogeneous Poisson process software reliability modeling. However, three well-known types have...
A pilot study for decellularizing porcine cornea for future use in corneal regeneration
Porcine corneas were decellularized for future use in corneal regeneration by using various washing steps with 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS) detergent, Benzonase,...
Impact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA)
Aims Angiotensinogen plays an essential role in maintaining circulatory homeostasis. AGT rs5050(T > G) has bee...
Reconstruction of a genome-scale metabolic model for Streptococcus zooepidemicus: Comparison with Corynebacterium glutamicum to study hyaluronic acid production
Comparison of Streptococcus zooepidemicus ( S. zooepidemicus ) as a natural strain for hyaluronic acid (HA) production w...
Impact of injection scheduling on CO2 migration and trapping efficiency in the Johansen formation
Injection scheduling is increasingly considered as an operational lever for optimizing carbon dioxide (CO 2 ) storage in saline aquifers, yet its long-term impa...
Evaluation of the reliability and risks of ChatGPT-4o in answering pediatric cough questions: A comparative analysis between pediatricians and pediatric pulmonologists
Introduction Artificial intelligence tools such as ChatGPT are increasingly used by patients and healthcare professionals, yet their reliability in pediatric respiratory conditions...
Clinical and social determinants of cardiovascular risk in a population with chronic noncommunicable diseases in Maicao, La Guajira, Colombia: 2024
Aim To determine the independent association and quantify the magnitude of influence of clinical and social determinants on the ten-year cardiovascular disease risk (estimated usin...
Transparent comparisons of Emergency-Department prioritization policies: integrating tail risk, target attainment, and utility analysis
Studies comparing emergency department (ED) patient prioritization rules often use single averages, which can hide important clinical trade-offs. This paper presents and demonstrates a three-part eval...
Candidate orphan genes: Reassessing uniqueness
Orphan genes lack recognizable homologues outside a given taxonomic unit; thus, they have uncertain evolutionary origins. This presents a profound challenge to traditional models of gene evolution. Th...
Whole-genome sequencing of Burkholderia glumae strains from Thailand reveals potential horizontal gene transfer with Burkholderia pseudomallei
Burkholderia glumae is an emerging phytopathogen that causes bacterial panicle blight in rice and has been implicated in rare human infections. In Thailand, B....
Evaluating milk quality indicators in the era of antimicrobial stewardship: A study of tennessee dairy farms (2011–2023)
This study evaluated temporal and seasonal trends in milk quality parameters: somatic cell count (SCC), fat, and protein content among Tennessee dairy farms from 2011 to 2023, with reference to the 20...
Phenology of nesting marine turtles in the Cayman Islands
Climate-driven shifts in the phenology of species are altering ecosystems worldwide and have been documented in many species, including marine turtles. We present a 26 year analysis of population tren...
Fourth-order kinematic analysis: Advanced decomposition methods for particle motion in modified orthogonal frame
The analysis of higher-order derivatives of position, particularly the snap (fourth derivative), provides critical insights into complex motion dynamics in fields such as robotics, aerospace, and biom...
Care needs of patients with chronic wounds for implementing a virtual care program: A qualitative study
Introduction Chronic and complex wounds are serious public health problems worldwide. Given the time-consuming nature of chronic wound healing and the need for long-term follow-up,...
Digital health determinants & divide in the Arab world: A cross-sectional study
Background Digital determinants of health include key technological factors such as internet access, digital literacy, and the quality of online health information. These elements...