PLoS ONE
Articles in this Issue
Magnitude of tuberculosis treatment outcomes and associated factors in public health institutions of Arba Minch town, Southern Ethiopia: A multi-centered retrospective cross-sectional study
Background In Ethiopia, the incidence rate of tuberculosis (TB) has been steadily increasing, from 119 per 100,000 in 2021–126 per 100,000 in 2022 and 146 per 100,000 in 2023. More...
Exploring the immune responses triggered by vaccine formulations containing the recombinant Schistosoma mansoni 14kDa fatty acid-binding protein
Many different Schistosoma antigens have been evaluated as vaccine candidates, including the recombinant form of the Schistosoma mansoni...
Beauty isn’t everything: An agent-based model of imperfect food acceptance and market utility balance
Imperfect or suboptimal foods—cosmetically flawed yet nutritionally sound—are frequently discarded across the food supply chain, contributing significantly to global food waste. Although farmers, reta...
Associations between refugee camp living and duration lived in refugee camps with health outcomes: A cross-sectional analysis of the Annual Survey of Refugees, 2021–2022
Introduction Refugees represent a growing, marginalized population who experience significant health disparities. Approximate 20% of refugees live in refugee camps. Quantitative st...
Hydrogen peroxide fogging of isolation gowns: Disinfection efficacy and VOC emissions
Isolation gowns constitute the majority of the PPE waste generated daily worldwide. Disinfection with reuse that is easily reproducible without the need for expensive equipment or trained personnel is...
Optical tissue clearing and 3D imaging of intact primate testicular tissue: a novel technology development
Classical histology struggles to preserve three-dimensional spatial context, prompting the emergence of optical tissue clearing techniques that enable imaging of intact specimens at cellular or subcel...
An exploratory study on the preparation of metallic rhenium (Re) and ReO3 via non-contact solution plasma electrolysis
Metallic rhenium (Re) and its oxides (e.g., rhenium trioxide ReO 3 ) have been extensively utilized in fields including national defense, aerospace, and electro...
Coaching doctors to improve ethical decision-making in adult hospitalized patients potentially receiving excessive treatment: Process evaluation study of the CODE intervention in doctors and nurses working in ten acute hospital wards
Introduction High quality hospital care for serious ill persons requires exemplary team-based communication and decision-making. However, there is a need for evidence-based interve...
Can nonpartisan primaries boost turnout and lessen demographic disparities?
U.S. congressional general elections are largely uncompetitive, featuring candidates who emerge from low-turnout primaries. Voters in these primaries are unrepresentative of the broader electorate; pr...
Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB
Interferon regulatory factors (IRFs) play key roles during viral and bacterial infections. However, their regulation by inflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor...
Mapping the evidence for patient and public involvement and engagement in statistical methodology research: A scoping review protocol
Objective To identify and map the existing literature on the conduct of patient and public involvement and engagement (PPIE) for statistical methodology....
Forecasting China’s shipping indices based on modal decomposition and optimized deep learning integrated model
This study proposes an innovative hybrid forecasting model, VMD-CPSO-BiLSTM, which significantly enhances the prediction accuracy of shipping indices in China’s maritime sector. The model employs a so...
RETRACTED: In silico investigation of novel Plasmodium Falciparum glycogen synthase kinase (pfGSk3β) inhibitors for the treatment of malaria infection
Malaria, a parasitic disease, remains a major global health concern, with over 260 million cases reported worldwide in 2023. As resistance to current antimalarial drugs increases, the demand for ongoi...
Longitudinal biomarker progression and validation for predicting operational tolerance in a prospective multicenter liver transplantation immunosuppression withdrawal trial
Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, but long-term immunosuppression (IS) is associated with significant side effects. Achieving operational tolerance (OT...
Comparative analysis of AI on human nutrition knowledge: Evaluating large language model-based conversational agents against dietetics students and the general population
Understanding the core principles of nutrition is essential in the contemporary context of abundant and often contradictory dietary advice, to empower individuals to make informed dietary choices and...
Blood draw site and blood matrix influence mineral assessment
Circulating mineral concentrations are used to assess nutritional status or as markers for clinical conditions, but the quality of these measurements depends on the methods used for blood processing....
Co-infections of Schistosoma mansoni and Helicobacter pylori in school-aged populations and implication for management and control practices in Niger State, Nigeria
Helicobacter pylori and Schistosoma mansoni are two important pathogens that infect the gastrointestinal tract, could be acquired earlier in...
Rapid progression and short-term mortality during the January 2023 to July 2024 Cholera outbreaks in Zambia: A retrospective facility-based study
Cholera remains one of the most rapidly fatal infectious diseases globally, with untreated cases leading to death within hours due to severe dehydration. Despite being preventable and treatable, it co...
Dementia is our “biggest expanding caseload”: Core learning for student speech and language therapists
Dementia is a relatively recent addition to the speech and language therapist’s clinical role. Given the increase in prevalence of dementia, a review of current student speech and language therapy tra...
A multi-mineral intervention to improve disease-related and mechanistic biomarkers in ulcerative colitis patients: Results from a randomized trial
Introduction The long-term goal of our ongoing studies is to determine if, and to what extent, a multi-mineral product (Aquamin) could benefit individuals with ulcerative colitis (...
Molecular mechanisms of lipid metabolism abnormalities driving sepsis and atrial fibrillation: A Systematic study based on bioinformatics and machine learning
Background Sepsis and atrial fibrillation are complex, life-threatening medical conditions affecting approximately 49 million individuals globally, characterized by exceptionally h...
Load-bearing mechanism and engineering application of a heavy-duty transfer steel platform supported by basement columns
Heavy lifting operations performed on basement roof slabs often impose concentrated loads that may cause local stress concentrations, cracking, or even structural failure. To address this issue, this...
Childhood abuse and adult cyberbullying victimization in Canada: The role of community belonging
Childhood abuse is linked to a higher risk of experiencing cyberbullying victimization in adolescence and young adulthood, while a sense of belonging is associated with a reduced risk and buffers agai...
DNA methylation-driven gene-based drug response prediction model for liver cancer: The critical role of GLS
Background Aberrant DNA methylation plays a pivotal role in cancer progression by enhancing oncogene activation or silencing tumor suppressor genes, contributing to malignant pheno...
Development and evaluation of a self-generated foam–resin composite sand consolidation system for offshore oil reservoirs
Sand production poses a major challenge in offshore heavy oil development, leading to casing erosion, equipment damage, and wellbore instability, which ultimately results in production decline. Conven...