PLoS ONE
Articles in this Issue
A novel preparation method for monodisperse streptavidin magnetic beads and its application in electrochemiluminescent immunoassay for CEA
The magnetic microspheres coated with streptavidin (PS-SA) were successfully prepared by loading streptavidin onto modified hyperbranched poly(glycerol) (HPG) magnetic microspheres. This material was...
Exploring the development of coach-parent relationships in organized competitive youth team sports
The purpose of this research was to gain a better understanding of coach-parent relationships in organized competitive youth team sports. Two qualitative studies were conducted with distinct samples f...
Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis
Introduction Preterm infants are at increased risk for hypertension due to incomplete organ development. With no established guidelines for treating hypertension in this population...
U.S. politics as a reminder of historical losses in American Indian Adults: Implications for political participation
Historical loss (HL) is a contributor to experiences of historical trauma and its negative impacts on American Indians. The relationship between HL, U.S. politics and political participation among Ame...
A qualitative study of bereavement support volunteers’ views and experiences on an online Acceptance and commitment therapy-based (ACT) training programme
Background Grief is a natural process, and many people will adjust in time with support from family and friends. However, evidence suggests that around 40% of bereaved people may b...
Flight delay prediction: Evaluating machine learning algorithms for enhanced accuracy
Flight delays pose substantial operational and economic challenges for airlines, directly affecting scheduling efficiency, resource allocation, and passenger satisfaction. Accurate prediction of arriv...
3D-MRI evaluation of cartilage thickness changes and their location in the patellofemoral joint after open wedge high tibial osteotomy for knee osteoarthritis: A retrospective cohort study
Background Open wedge high tibial osteotomy (OWHTO) has been widely established as a safe surgical procedure for medial compartmental knee osteoarthritis. However, concerns remain...
Contribution of xpert MTB/RIF assay and Urine LF-LAM for the diagnosis of tuberculosis in children aged 5 – 14 years, at selected health facilities in Ethiopia, 2016 – 2019
Background Childhood tuberculosis (TB) remains under-reported and undiagnosed. A full complement of diagnostic tests is oftentimes unavailable in resource limited country like Ethi...
Judging the unseen: The impact of onset controllability in shaping perceptions of defendants with traumatic brain injury
Traumatic brain injury (TBI) has been associated with increased risk of criminality, yet very little is known about how individuals with TBI may intersect with the adjudication phase of the criminal j...
Phase 1, randomized, crossover study comparing intravenous GTX-104 to oral nimodipine in healthy human subjects
Enterally-administered nimodipine is the only approved drug formulation available in the United States for treatment of patients with aneurysmal subarachnoid hemorrhage. Intravenous nimodipine is avai...
Can participatory budgeting mitigate government debt risk？—An empirical analysis using cross-national panel data
Objectives Participatory budgeting, serving as a complementary mechanism to traditional democratic practices, grants citizens direct involvement in the budgetary decision-making pr...
Hybrid backdoor attacks for deep code models
Deep code models face security vulnerabilities through backdoor attacks. Previous approaches have primarily relied on single-trigger mechanisms, resulting in limited stealth and vulnerability to defen...
Measuring spatial accessibility for wheelchair users: A case study in a Chinese campus
Barrier-free campus environment is essential for students and staffs with mobility impairment. However, few studies have empirically examined the spatial accessibility for wheelchair users within the...
Audition and balance: The impact of echolocation on postural control
The links between the perception of acoustic signals and postural control remain largely unexplored, and the control models proposed to date have yet to assign these sensory inputs a role alongside vi...
Smartphone-supported Positive Adjustment Coping Intervention (PACI) for couples undergoing fertility treatment: A randomised controlled trial
Background Couples undergoing fertility treatment experience emotional stress. Meta-analyses show heterogeneous results regarding the effectiveness of psychosocial interventions on...
High-risk human papillomavirus genotypes among women of hill districts in Bangladesh
Knowledge on the distribution of type specific HPV (Human papillomavirus) genotypes in female cervix is crucial to identify women who are at a higher risk of developing cancer. This study aimed to fin...
Comparing RNA extraction protocols from formalin-fixed paraffin-embedded microcore samples
The ability to analyze intratumoral heterogeneity is of great interest for both diagnostic and basic research purposes. However, currently available dissection techniques are unsuitable for routine us...
Cooperative environmental engineering via biofilm formation can stabilize consumer-resource systems
Cooperation can stabilize consumer-resource dynamics, preventing over-exploitation driven by individual self-interest. The maintenance of cooperation in such systems is often attributed to individual-...
Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients
Objective The association between lactate dehydrogenase (LDH) and clinical outcomes in sepsis was explored based on MIMIC-IV database....
Quality of referral system and associated factors among referred clients referred to dessie comprehensive specialized hospital, Northeast, Ethiopia
Background An effective referral system acts as a connection among the three tiers of healthcare in Ethiopia, ensuring the seamless provision of appropriate health services. The su...
Changes in quality of life over time through the lens of young people aged 18–24 in 2016 in Gauteng Province of South Africa
Young people in South Africa face many challenges that include high unemployment, economic hardships, high rates of crime, alcohol and substance abuse, violence, anxiety, depression, and trauma. Quali...
STF-DKANMixer: Tri-component decomposition with KAN-MLP hybrid architecture for time series forecasting
Long-term time series forecasting is critical for domains such as traffic and energy systems, yet contemporary models often fail to capture complex multiscale patterns and nonlinear dynamics, resultin...
Building extraction from remote sensing imagery using SegFormer with post-processing optimization
Traditional methods for building extraction from remote sensing images rely on feature classification techniques, which often suffer from high usage thresholds, cumbersome data processing, slow recogn...
Stakeholder communication and client understanding of viral load suppression in Blantyre, Malawi—What role did U = U play before the flip the script campaign?
Background Various studies have demonstrated the effectiveness of viral load suppression (VLS) in preventing sexual transmission of the human immunodeficienc...
IconicITA: Iconicity ratings of the Italian affective lexicon
Iconicity, defined as the potential of linguistic signs to resemble properties or features of their referents, is increasingly recognized as a general property of language. One common approach for qua...