PLoS ONE
Articles in this Issue
Nutrient film technique systems for coriander production: A comparison of aquaponics and hydroponics in UAE
As global populations rise, the need for sustainable agricultural practices becomes increasingly urgent, especially in regions facing water scarcity and harsh environmental conditions. Traditional far...
Patient preferences for incentives in Contingency Management interventions in methadone treatment: A best-worst scale analysis
Background Contingency management (CM) effectively enhances adherence and retention in methadone maintenance treatment (MMT). But implementing CM in resource-limited settings is ch...
Oxyphenbutazone improves memory and learning impairments in LPS-induced neurotoxicity via modulating TGF-β/NF-κB/IκB-α pathways: In silico and in vivo study
Objective Neuroinflammation and oxidative stress play key roles in cognitive decline and memory impairments. This study employed a lipopolysaccharide (LPS)-induced neurotoxicity mo...
Integrated reconstruction of January and July temperature series in the Sanjiangyuan region during the Holocene
The Sanjiangyuan region, located in the hinterland of the Qinghai-Tibet Plateau(QTP), is highly sensitive to global climate change. Reconstructing its Holocene January and July temperatures is crucial...
Dynamic response analysis of concrete box subgrade under double-line heavy-haul railway
The concrete box subgrade, a novel structural form constructed from reinforced concrete to replace conventional fill subgrades, effectively addresses challenges associated with land scarcity and mater...
Digital inclusion and urban-rural integration: Mechanisms and regional heterogeneity in China
Although digital inclusion is globally recognized as a key pathway to equitable development, rigorous empirical evidence on its specific mechanisms and regionally varying effects in driving urban-rura...
The effect of different borehole spacing and detonation time difference on crack propagation in double-hole shaped charge blasting
Achieving precise through-crack between shaped charge blasting holes depends critically on the design parameters of the blasting operation. This study investigated the influence of borehole spacing an...
Pregnancy and epileptic seizures in the emergency department setting: A retrospective analysis
Background This study evaluated the clinical features, management, and outcomes of pregnant women with generalized tonic-clonic seizures presenting to the emergency department (ED)...
FetCAT: Cross-attention fusion of transformer-CNN architecture for fetal brain plane classification with explainability using motion-degraded MRI
Fetal brain magnetic resonance imaging (MRI) has been recognized as a vital diagnostic tool for identifying neurological anomalies during pregnancy. Accurate classification of fetal MRI planes is esse...
Pneumonia and pneumothorax detection: A multi-factor evaluation of chest X-rays
The research creates a Vision Transformer (ViT) diagnostic system which identifies pneumonia and pneumothorax from chest radiographs through analysis of the NIH ChestX-ray14 dataset. The research meth...
Folding and unfolding: A topological framework for understanding intangible cultural heritage tourism in urban villages - The case of chebei dragon boat scenery, Guangzhou, China
Background Rapid urbanization poses unprecedented challenges to intangible cultural heritage (ICH) preservation, particularly within urban villages where traditional practices face...
Combination of ultrasonography and MRI for preoperative prediction of lymph node metastasis in tongue squamous cell carcinoma: An exploratory study
Preoperative depth of invasion (DOI) is a critical predictor of cervical lymph node metastasis (CLNM) in tongue squamous cell carcinoma (TSCC). Ultrasonography (US) offers high accuracy for shallow tu...
Blockchain adoption in remanufacturing under carbon tax policies: A game theory analysis of industry dynamics and consumer impact
Within the context of China’s “dual carbon” goals, remanufacturing of waste products has garnered significant government interest due to its potential to reduce carbon emissions during production and...
In their own words: A qualitative examination of student experiences with high-impact practices during the second-year transition
Researchers and practitioners have called for the use of high-impact practices to support student engagement and development in higher education institutions in the United States. Many studies have us...
Self-esteem in crisis: Psychosocial adaptation and masculine identity among Chinese men with azoospermia
Background Azoospermia affects 1% of men and 10–20% of infertile males, yet the psychosocial mechanisms underlying self-esteem impairment remain poorly characterized. Guided by Con...
Bacterial community associated with the surface and inside of centipede forcipules: Identification and characterization
Background In tropical to subtropical regions, centipede bites may prompt medical attention, with manifestations largely reflecting venom-related discomfort, although infections, i...
Adaptive and migration-enhanced tree seed algorithm for multi-threshold CT image segmentation and lung cancer recognition
The Tree-Seed Algorithm (TSA) is a swarm intelligence algorithm inspired by the propagation relationship between trees and seeds. However, the original TSA is prone to premature convergence and become...
Predicting grain growth kinetic in steels using machine learning and XAI for mechanical properties
Understanding and controlling grain growth kinetics in steels is crucial for optimizing mechanical properties during thermomechanical processing. However, traditional empirical models often fail to ac...
An immunofluorescence microscopy assay to discriminate distinct expression patterns of HIV-1 Gag and Nef proteins in HIV-1 provirus-harboring cells
Over 95% of HIV-1 proviruses are defective and were once considered clinically irrelevant. However, growing evidence shows that these defective proviruses can still be transcribed and translated into...
DC-STAMP activates the PI3K/AKT/mTOR signaling pathway to regulate PANoptosis in acute myeloid leukemia
Background PANoptosis is a newly defined form of programmed cell death that integrates features of apoptosis, pyroptosis and necroptosis, playing a critical role in immune regulati...
The quality and safety of Rhodiola rosea supplements on the U.S. market: An analysis of biomarkers, heavy metals, and pesticide residues
Rhodiola rosea supplements have become popular in the U.S., with a $3.4 billion market and an annual growth of about 10% in sales in the past few years. While the health benefits o...
Determinants and strategies for environmental compliance in municipalities: Perspectives from KwaZulu-Natal Province, South Africa
Background A commitment to local environmental compliance is essential for ensuring a sustainable environment for future generations. Despite South Africa’s extensive environmental...
Radiomics profiling combined with clinical risk factors for preoperative Lymphatic Metastasis prediction in Colorectal cancer: A multicenter study
Purpose Accurate preoperative assessment of regional lymphatic metastases (LNM) is essential for effective surgical selection of patients with colorectal cancer (CRC). This study a...
Towards practical AI for agriculture: A self-supervised attention framework for Spinach leaf disease detection
Malabar spinach is a nutrient-dense leafy vegetable widely cultivated and consumed in Bangladesh. Its productivity is often compromised by Alternaria leaf spot and straw mite infestations. This work p...
The global burden of age-related hearing loss among individuals aged 60 years and older: An analysis for the global burden of disease study 2021 and predictions to 2050
Objectives Age-related hearing loss (ARHL) impacts communication, cognitive function, and mental health, with regional prevalence variation. We analyzed global spatial and temporal...