PLoS ONE
Articles in this Issue
Alterations in the CTRB2 gene and response to chemotherapy in pancreatic cancer
Background Pancreatic ductal adenocarcinoma (PDAC) remains a highly fatal malignancy due partly to treatment resistance in many patients. We previously ident...
Habitat associations of Chihuahua Chub (Gila nigrescens) and Rio Grande Sucker (Pantosteus plebeius) in the Mimbres River, New Mexico
Fish species in arid regions have suffered from disproportionate declines due to anthropogenic activity. Therefore, many arid-region fishes are species of conservation concern and a primary focus of m...
Application of NMRK immobilized enzymes in the synthesis of NMN
The purpose of the study is to provide a method for mass production of nicotinamide mononucleotide (NMN) using an immobilized nicotinamide riboside kinase (NMRK). We synthesized a gene sequence compri...
Expression of Concern: Creating a novel algorithm for studying the strong convergence to a sequence with applications
Retraction: Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2
The effect of self-concealment on post-traumatic stress symptoms in breast cancer patients: The mediating role of experiential avoidance
Background Breast cancer is a major global health issue. It brings death threats or serious physical injuries to patients, and is a traumatic event that can seriously affect their...
Current status and influencing factors of telehealth readiness among nurses: A multicenter cross-sectional study in Ningxia, China
Background Telehealth has become an increasingly important approach in healthcare delivery, particularly in improving accessibility, continuity, and efficiency of nursing services....
Early psychometric characteristics of the NUrsing Behavioral Engagement (NuBE) Scale in cancer settings: A three-phases validation study
Background Patient engagement in cancer care is increasingly recognized as essential for improving clinical outcomes. Nurses play a crucial role in fostering patient engagement, ye...
Effect of virtual group counseling based on health literacy on the empowerment and self-care of pregnant women: A randomized controlled trial
Introduction Pregnancy presents a valuable opportunity for education and counseling aimed at enhancing the health outcomes of both mothers and newborns. This study was conducted to...
Assessment of immunogenicity and protection induced by COBRA HA vaccines formulated with Infectimune in young and elderly ferrets
Influenza viruses cause seasonal epidemics resulting in substantial morbidity and mortality, particularly in the elderly population. Although annual high-dose or adjuvanted influenza vaccines help mai...
Open-source framework for detecting bias and overfitting for large pathology images
Even foundational models trained on large-scale datasets may learn to rely on non-relevant artifacts such as background color or color intensity, leading to overfitting and/or bias. To ensure the robu...
Genomic diversity of Ligularia revealed by complete plastid genomes and nuclear ribosomal DNAs from 16 collections in Korean Peninsula and Mt. Hallasan
Plastid genome (plastome) and nuclear ribosomal DNA (nrDNA) sequences were assembled from 16 Ligularia accessions, including L. fischeri...
Acute kidney injury and hyponatremia in hospitalized patients with rotavirus infection
Introduction Rotavirus is a common cause of infectious gastroenteritis in infants and children. The role of rotavirus infections in adults has potentially been underappreciated and...
Restoring degraded soils: The transformative impact of Fanya Juu terraces on soil characteristics in the erosion-prone Magera watershed, Southern Ethiopia
Excess runoff-induced soil erosion significantly degrades farmland fertility, quality, agricultural productivity, and long-term sustainability. Although Fanya Juu terraces are widely implemented for m...
Estimating post-operative complication rates in patients with primary brain tumours from routine administrative data: A national cohort study
Introduction Neurosurgery is an important element of brain tumour treatment but carries with it the risk of complications. Previous work has defined a narrow set of general post-op...
A video intervention reduces racial bias in a representative sample of US adults: A brain as predictor study
Biased attitudes and behaviors towards racial minorities in the US are pervasive, enduring, and detrimental. We tested whether a video illustrating the negative effects of racial bias towards African-...
GUI test case minimization using sequence mining
Graphical User Interface (GUI) testing is a crucial aspect of software quality assurance, ensuring that the user-facing components correctly reflect the underlying business logic. Regression testing v...
Synergistic effects of antibiotics and fucoidan on dual-species Staphylococcus aureus and Acinetobacter baumannii biofilm in diabetic rat wound models
Background Chronic diabetic wounds are often complicated by biofilm-forming, antibiotic-resistant pathogens such as Staphylococcus aure...
Total mercury contamination in fish species of Northwestern Ecuador and potential human health risks
Gold mining activities are often suspected to increase mercury pollution-associated with human health and ecological risks in aquatic ecosystems. The objective of this study was to quantify total merc...
Chondroitin sulfate alleviates osteoarthritis by upregulating HSPA8 to inhibit chondrocyte ferroptosis
Osteoarthritis (OA) is a prevalent degenerative joint disease with no curative treatment currently available. Recent evidence suggests that chondrocyte ferroptosis contributes to OA progression. Chond...
Evaluation of dentists’ awareness, knowledge, and clinical practices regarding early-stage oral cancer lesions in Türkiye: A cross-sectional study
This cross-sectional study aimed to evaluate dentists’ awareness, knowledge, and clinical practices regarding early-stage oral cancer lesions, with an emphasis on diagnostic behavior, patient educatio...
Correction: Prevalence and factors influencing drug-resistant tuberculosis in four regions of Ghana
Investigating the predictive power of seismic statistical features using ensemble learning
Earthquake prediction is an extremely challenging problem, one that has been in the past (and sometimes still is) claimed to be impossible. Given this undisputed high level of difficulty, work that re...
Iran is falling behind WHO cervical cancer elimination targets: HPV vaccination coverage and cervical cancer screening participation in 2021
Objective This study aimed to assess HPV vaccination coverage and cervical cancer screening participation among Iranian females under 46 years old, comparing Iran’s situation to he...
Rapid bacteriophage quantification with a particle size analyzer combined with polarization intensity differential scattering (PIDS) detector
The study of bacteriophages (phages) and effects on their microenvironments expanded exponentially within the last decade. While there are multiple described methods for phage quantitation, there is s...