PLoS ONE
Articles in this Issue
Multi-omics analysis identifies PPARα as a key inhibitor of hepatocyte ferroptosis in sepsis-associated liver injury
Background Sepsis-associated liver injury (SLI) increases the risk of death in septic patients, and a primary pathological alteration in sepsis is ferroptosis in the liver. However...
Development and validation of the Physical Capacity Score (PiC) to overcome the lack of correlation among traditional physical tests in detecting age-related decline
We developed the Physical Capacity Score, a set of validated and commonly used physical tests for adults, administered through a custom-built hardware and software platform that enables automated data...
A study of consumer-generated advertising—An experimental analysis based on purchase experiences, information channels, and privacy costs
Taking consumer-generated advertising as the research object, hypotheses are proposed on the influential relationship between purchase experiences, information channels and privacy costs and consumer-...
Situational influences on officiating performance: An analysis of foul calls in the Chinese basketball association league (CBA)
The growing emphasis on situational variables has significantly advanced research in sports performance analysis, yet studies focusing on referees from this perspective remain limited. This study exam...
Uncovering the hidden yeast diversity in fermented coffee: Insights from a shotgun metagenomic approach
Yeasts play a pivotal role in coffee fermentation, shaping microbial succession and contributing to the development of final flavor profiles. Despite their importance, yeast taxonomy in this context r...
Socioeconomic determinants of virtual care use among people living with HIV in a clinical cohort in Ontario, Canada: A cross-sectional study
Background Retention in HIV care is essential for achieving optimal health outcomes and extending life expectancy among people living with HIV. However, socioeconomic challenges fr...
Correction: Poor reporting quality of randomized controlled trials comparing treatments of COVID-19–A retrospective cross-sectional study on the first year of publications
The equity implications of exposure to industrial livestock operations
Concentrated animal feeding operations, particularly hog and poultry farms, have expanded rapidly in North Carolina in recent decades. The air and water pollution they generate cause many environmenta...
Protocol for the ‘exploration of mental well-being, health-related quality of life, and psychosocial outcomes in youths on dialysis in New Zealand: A cross-sectional methods study’
Introduction It is well accepted that young individuals on dialysis have poor clinical outcomes, although it is increasing apparent that they have similarly poor patient-centred on...
On the Gaussian distribution of the Mann-Kendall tau in the case of autocorrelated data
Non-parametric Mann-Kendall tests for autocorrelated data rely on the assumption that the distribution of the normalized Mann-Kendall tau is Gaussian. While this assumption holds asymptotically for st...
Contrastive learning-driven spatiotemporal dynamically adaptive framework for stylized 3D human motion generation
Most existing methods for 3D human motion generation focus primarily on global style statistics in the temporal dimension, which limits their ability to capture local stylistic variations in dynamic m...
Mirror-gazing-induced dissociation impairs self-reported and implicit sense of agency: A causal investigation of dissociation and agency under controlled laboratory conditions
Dissociation and sense of agency disruptions are related, but the causal pattern between them is unknown. This two-phase study explored whether laboratory-induced dissociative experiences impair the s...
Beyond the baby schema: Objects being touched are perceived to be cute
Research on cuteness has traditionally focused on the baby schema, which is used to describe the physical characteristics of an individual. Recent research, however, has shown that the characteristics...
Scenario-based portfolio optimization via bootstrapping and machine learning methods: Theory development and empirical evidence from the Tehran Stock Market
Predicting future returns and modeling return uncertainty are essential yet challenging tasks in portfolio optimization. To address these issues, this study proposes a hybrid approach combining machin...
TL1A serves as a positive regulator to promote adipocyte differentiation
Adipogenesis, the intricate process of differentiation from preadipocytes or mesenchymal stem cells into mature adipocytes, is crucial for the formation and metabolic function of adipose tissues in ma...
Supporting the creative industries through the AI turn: A comparative analysis of Scottish policy and the needs of Scotland’s creative practitioners
In the creative industries (one of the largest UK sectors, which operates at the juncture of business, technology and the arts) creative practitioners are not only consumers of Artificial Intelligence...
Application of functional regression in biomechanical assessment of neck disability: Selection of clinically relevant variables
Background : The Neck Disability Index (NDI) is widely used to assess neck pain-related disability. It is commonly combined with objective measures, particularly range of motion an...
Sources of individual variability in a pragmatic reference game: Effects of logical reasoning and Theory of Mind
While in theory people are expected to adhere to rational communicative principles, a growing body of work shows that people vary widely in their tendency to draw pragmatic inferences. It has been sug...
Incorporation of lipids improves cryo-tolerance of vitrified gorgonian coral oocytes
Coral reefs, which are crucial to the health and diversity of the global marine ecosystem, have experienced substantial declines due to climate change and human activities. Cryopreservation, the long-...
Exploring the views and experiences of frailty and resilience among people experiencing homelessness in Ireland: A qualitative study
Background People experiencing homelessness (PEH) have high levels of frailty. However, their views on frailty, resilience, and the broader contextual factors that shape these expe...
Public-private mix in health systems and repercussions for health inequalities in Latin American countries: A scoping review protocol
Introduction Health system models in Latin American countries express differences in the state’s role in regulating, financing and providing health services, as well as in the coex...
Higher education student engagement in learning activities: Clarifying concepts and introducing a short-scale
Student engagement plays a vital role in higher education due to its significant influence on academic outcomes, such as academic achievement and course completion. However, the concept of student eng...
Prevalence and associated factors of skin disease among school-age children of rural district of eastern zone of Tigray, Ethiopia, 2024
Background Skin diseases are conditions that affect the skin. Skin diseases encompass various conditions, including infections, allergies, inflammatory disorders, and infestation....
Serum Amyloid A (SAA) induces transcription affecting inflammation
The 104 aa protein Serum Amyloid A (SAA) is a prominent member of the acute phase response (APR) a remarkably conserved and stereotyped set of serum protein changes associated with inflammation and ot...
Assessment of practices and barriers toward nasogastric tube rehydration for moderate and severe dehydration due to diarrheal disease in under-five children among health centers in Gamo Zone, Ethiopia
Introduction Dehydration from diarrheal diseases remains a common cause of morbidity and mortality in developing countries. Nasogastric tube is an easy, efficient, and cost-effecti...