PLoS ONE
Articles in this Issue
Dietary inflammatory index in relation to incident CKD: A prospective study of UK Biobank participants
Background and objectives The relationship between increased inflammatory diet patterns and chronic kidney disease (CKD) remains unknown and has not been investigated in large coho...
Rosuvastatin protects against oxLDL-induced endothelial cell oxidative stress and attenuates atherosclerotic plaque formation in ApoE-/- mice through the NF-κB pathway
Cardiovascular disease is one of the diseases with the highest global incidence and mortality rates, and atherosclerosis is its basic cause. Endothelial dysfunction induced by risk factors such as lip...
Prediction of COVID-19 hospitalisation, ICU admission or death following ChAdOx1 vaccination using artificial intelligence: A clinical predictive model from the English RAVEN study
Objectives This study identifies predictors of severe COVID-19 following completion of two-dose primary series of the AZD1222 COVID-19 vaccine, employing eXtreme Gradient Boosting...
Psychological and lifestyle correlates of eating behavior and adiposity: Structural and latent profile modeling
Background Psychological vulnerabilities, including early maladaptive schemas (EMS) and difficulties in emotion regulation, are associated with dysregulated eating and adiposity. H...
Declining laser peripheral iridotomy for angle closure alongside rising cataract surgeries: A nationwide cohort study in South Korea
Purpose To examine recent nationwide trends in cataract surgeries and laser peripheral iridotomy (LPI) in Korea, and to assess their temporal association and patient-level characte...
Developing a safe culturally competent framework in a multicultural hospital through participatory action research: Study protocol
Background Healthcare settings are becoming increasingly multicultural. As a result, cultural factors play a bigger role in patient care. This raises an important question: are hea...
Coral spawning patterns in the Gulf of Thailand reveal synchronised annual daytime spawning, with a review of spawning patterns in Pavona corals across the Indo-Pacific
Global documentation of coral spawning has been increasing, yet remains restricted to corals and reefs for which established patterns have largely been identified, being overwhelmingly associated with...
Parental behavior, adult attachment, and DNA methylation of the MT2 oxytocin receptor gene region – The moderating role of neuroticism
Parental behavior, especially in childhood, affects the child’s development in numerous ways. Over the last decade, the aim to get a deeper understanding of how early experiences influence behavior la...
Role of ethics, meritocracy, and professionalism in public sector reforms: A Q methodology study
Public sector reforms are crucial for improving governance efficiency, accountability, and service delivery. Their success, however, hinges on key factors such as ethics, meritocracy, and professional...
Scarcity mindset’s positive association with using alternative financial services
The scarcity mindset, where people do not have what they feel that they need, can help consumers address the area of scarcity, but on the other hand can lead to neglect and mistakes elsewhere. This st...
Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-infections: Therapeutic implications
CMV/HIV coinfection markedly exacerbates disease progression, elevates treatment failure risk, and worsens patient outcomes, yet the underlying molecular mechanisms remain incompletely understood—crea...
The potential value of thromboelastography and conventional coagulation detection in guiding the management of venous thrombosis after traumatic brain injury
Background Coagulation disorders are serious complications of traumatic brain injury (TBI), yet the predictive value of thromboelastography (TEG) for deep vein thrombosis (DVT) in...
Diabetic kidney disease in northwest Ethiopia: Prevalence and determinants among adults with type 2 diabetes
Background Diabetic kidney disease (DKD), mainly due to type 2 diabetes (T2DM) is the leading cause of end-stage kidney disease globally. However, DKD prevalence in sub-Saharan Afr...
Integrating phytochemical analysis and experimental validation of Ziziphus jujuba seed powder and oil to ameliorate CCl4-induced liver fibrosis in sprague dawley rats
Liver fibrosis, a consequence of chronic liver injury, is characterized by excessive accumulation of the extracellular matrix, oxidative stress, and activation of hepatic stellate cells. This study ev...
Walk and listen: A multidimensional study on the soundscape of a University District
Human perception of a surrounding environment comes from our senses. Among these, vision has been considered the most important but, nowadays, the hearing perception features are attracting even more...
When algorithmic managers fail to fulfill their promises: The role of anthropomorphism in shaping justice perceptions
This study explored how employees perceive distributive justice (i.e., perceived fairness of an outcome) when algorithmic managers fail to fulfill their promises. Moreover, drawing on anthropomorphism...
Intention to emigrate after graduation among medical students from two universities in Lima, Peru
Objective To determine the prevalence of the intention to emigrate among third- to seventh-year medical students from two private universities in Lima, Peru....
Comprehensive in silico analysis of genetic landscape and pathways involved in Stickler syndrome
Stickler syndrome is a collection of hereditary conditions that impact connective tissue, mainly collagen, and can cause a variety of symptoms, such as joint and bone abnormalities, hearing loss, and...
Research on the mechanism how consumer expected regret affects market access for pirated information products
In the past, traditional supervision of pirated information products mostly adopted a post incident disposal model. Under the supervision of government departments and the continuous improvement of ma...
An update on posterior-approach blepharoptosis surgery: Influence of clinical factors on surgical outcomes
Purpose To assess how preoperative clinical factors influence surgical outcomes following posterior-approach blepharoptosis repair....
Medication adherence trajectories and association with risk factors and clinical outcomes in type 2 diabetes treatment
Background Monitoring medication adherence and main clinical outcomes changes in type 2 diabetes (T2D) is essential for optimal patient management. This study aimed to compute and...
Enhanced medical image segmentation using optimized bidirectional LSTM and dolphin partner optimizer
Medical imaging has become a standard in diagnosing and treating how organs and tissues operate. In earlier systems, machine learning approaches were used for segmentation over a long period. Thus, pr...
An analysis of WHO FluNet and FluID influenza surveillance data for South East Asia Region, 2015–2023
Background Influenza is known to cause seasonal epidemics and recurrent pandemics and demands robust surveillance systems for strain detection and trend monitoring. There are globa...
Projecting spatiotemporal changes in Soil Organic Carbon stocks in Mexico under coupled socioeconomic and climate scenarios
Soil organic carbon (SOC) sequestration is a pivotal strategy for achieving global climate goals, yet current projections often rely on static landscape assumptions that fail to capture the complex in...
Development of a multiplex ddPCR assay for simultaneous absolute quantification of bacterial, fungal, and human DNA
Molecular methods in clinical and research applications frequently encounter complex mixtures of human and microbial DNA, sometimes alongside environmental or reagent contaminants. In metagenomic stud...