PLoS ONE
Articles in this Issue
Banana 0.9: An open-source, reproducible medical imaging system for low-resource gastric cancer screening
Background Gastric cancer remains a major global health burden, particularly in East Asia, yet early-detection programs are often limited by computational constraints, variable ima...
Cost-effective DNA extraction method optimized for high yield and long fragments from coastal sediments
Efficient DNA extraction from coastal sediments is a critical step for studying microbial communities, especially when targeting high-molecular-weight DNA for long-read sequencing. Here, we compare a...
Gendered perspectives of yoga in the Key Stage 1 classroom: Qualitative content analysis indicates contrasting views of teachers and pupils
The gendering of physical activities is ubiquitous, with those involving strength, endurance, and physical contact considered masculine, and those involving concentration, presentation, and flexibilit...
Automatic segmentation of coronary plaques in coronary CT angiography using neural networks
Rapid and accurate detection of coronary plaques on CCTA is critical for timely CAD diagnosis but is limited by reader workload and interobserver variability. Our objective was to evaluate the effecti...
Hayman’s diallel analysis for yield-related traits in F1 and F2 durum wheat (Triticum durum Desf.) progenies
This study employed Hayman’s diallel analysis to investigate the inheritance patterns of eight agronomic traits in durum wheat ( Triticum durum Desf.) using a 4...
A deep learning framework for gait-based frailty classification using inertial measurement units
Frailty in older adults leads to heightened vulnerability to adverse health outcomes, significantly burdening individuals and society by increasing healthcare costs and dependency. To address this iss...
A fuzzy ZE-number group decision-making framework using BWM and MABAC for risk assessment in medicinal plant extraction
The extraction of bioactive compounds from medicinal plants is a crucial process in pharmaceutical and herbal medicine industries, yet it presents numerous challenges that can compromise quality, effi...
Development of DHODH inhibitors incorporating virtual screening, pharmacophore modeling, fragment-based optimization methods, ADMET, molecular docking, molecular dynamics, PCA analysis, and free energy landscape
The overexpression of dihydroorotate dehydrogenase (DHODH) in various malignant tumor cells is significantly associated with ferroptosis, making DHODH inhibition a promising strategy for cancer therap...
Targeted near-infrared imaging utilizing a cathepsin-activated fluorophore for the intraoperative detection of canine insulinoma
Objectives The aim of this study was to evaluate the use of cathepsin-activated intraoperative near-infrared (NIR) imaging to detect insulinomas in dogs, a spontaneous large animal...
Integrated bioinformatics-based identification of proliferative diabetic retinopathy and idiopathic pulmonary fibrosis: Focus on fibrosis and immune infiltration
Proliferative diabetic retinopathy (PDR) and idiopathic pulmonary fibrosis (IPF) share the common pathological feature of fibrosis, but the connecting mechanisms are not well – understood. This study...
Incorporating topical stance into signed bipartite networks for user retweet prediction
Social networks accelerate information dissemination, and retweet behavior is an important way of user interaction. User retweet prediction analyzes user characteristics to predict retweet behavior an...
Mask - Region-based Convolutional Neural Networks (R-CNN) with Radiomics Integration and Gray Level Co-occurrence Matrix (GLCM) for brain tumor detection and segmentation
Early diagnosis of brain tumors is important for successful treatment and better patient consequences in industrial information systems. This research employs Mask Region-based Convolutional Neural Ne...
Drug-induced upper gastrointestinal bleeding: A real-world pharmacovigilance study
Background Drug-induced upper gastrointestinal bleeding (UGIB) is a serious adverse event that deserves close attention. This study conducted a real-world pharmacovigilance researc...
Dissecting the shared genetic architecture of bipolar disorder, major depressive disorder, and attention-deficit hyperactivity disorder
Major depressive disorder (MDD), bipolar disorder (BPD), and attention-deficit hyperactivity disorder (ADHD) are prevalent, highly heritable psychiatric disorders with significant degrees of genetic o...
Malaria and malnutrition in children under the Seasonal Malaria Chemoprevention (SMC) coverage in the health district of Nanoro, Burkina Faso
Introduction Malaria and malnutrition are major causes of childhood morbidity and mortality. Most of children receiving Seasonal malaria chemoprevention (SMC) are also generally ma...
Changes in leisure time physical activity, obesity-related morbidities, fatal and non-fatal CVD events and total mortality: Over 20-year follow-up in the opera study
Background The impact of changes in leisure time physical activity (LTPA) is not well-documented, especially when considering occupational physical activity (OPA). This study exami...
Retraction: Fischer’s ratio and DNA damage in hypoxemia-induced brain injury in rat model: Prophylactic role of quercetin and mexamine supplementation
Anemia and its associated factors among women of reproductive Age in Zambia: A multilevel mixed-effects analysis
Background Anemia remains a major global health crisis, affecting over 500 million women of reproductive age, with high burdens in resource-limited regions like Sub-Saharan Africa....
International consensus on sports, exercise, and physical activity participation during post-operative interventions for Adolescent Idiopathic Scoliosis: An e-Delphi study
Introduction Physiotherapists and surgeons have a significant role in promoting participation and offering a graded return to sports, exercise, and physical activity following spin...
Factors associated with psychological wellbeing, is education one of them?
Many factors, such as health, marital status, social relationships, and job status, influence psychological wellbeing. Previous research has suggested that educational attainment is also a key contrib...
Holding the line: Provider and patient perspectives on Medications for Opioid Use Disorder continuity during the war in Ukraine
Background Ukraine has one of the highest rates of opioid use in Eastern Europe, with an estimated 346,900 people who inject drugs (PWID). Medications for opioid use disorder (MOUD...
Association between different metabolic obesity phenotypes and colorectal adenoma
Background Obesity and metabolic abnormalities are independently and interactively associated with colorectal adenoma (CRA). This study aimed to investigate the association between...
The involvement of attentional biases in endogenous pain inhibition and autonomic reactivity
Background Attention is a key factor in shaping pain perception and modulation, yet its role in explaining individual differences in endogenous pain inhibition—commonly assessed in...
Hyperspectral imaging for intraoperative brain tumor identification through fusion of spectral, textural, and spectral index features
Brain tumor is a common neurological surgical disease, where surgical resection is the primary treatment method. Neurosurgeons need to accurately determine the location of the tumor during tumor resec...
Survival study of cytoreductive prostatectomy for prostate cancer with lung metastasis: A propensity score matching study based on the SEER database
Objective To investigate the specific tumor survival situation of cytoreductive prostatectomy for prostate cancer with lung metastasis....