PLoS ONE
Articles in this Issue
Assessing the national essential medicines list selection processes: Instrument development and testing
Background National Medicines Policies use the National Essential Medicines Lists (NEML) to improve equitable access to medications. An effective list selection process should addr...
Retraction: ω3-PUFAs Exert Anti-Inflammatory Activity in Visceral Adipocytes from Colorectal Cancer Patients
Burnout among disability activists in England: Insights from the Oldenburg Burnout Inventory
Objectives To contribute to the understanding of burnout among Disabled activists in the disability movement - ‘disability activists’ - in England using the Oldenburg Burnout Inven...
The effects of prophylactic use of paracetamol on body temperature and blood pressure in elderly patients with acute stroke: Data from the PRECIOUS trial
Background and aims Prophylactic administration of paracetamol (acetaminophen) has been reported to reduce body temperature in the first day after stroke and to reduce blood pressu...
Fetal yawning and mouth openings: Frequency, developmental trends, and association with birth weight
During the last 15 years, the brain cooling hypothesis has shown unparalleled explanatory and predictive power among the several attempts aimed at elucidating the phylogenetic origins of yawning. Howe...
TaqMan qPCR quantification of the Cytb gene for precise determination of camel milk in dairy products
Camel milk often faces quality control problems because it is vulnerable to adulteration with inferior dairy sources or plant-derived additives. Many existing DNA-based detection methods rely on suita...
Yield and nutrient augmentations in wheat: Application of plasma processed zinc
Billions of people worldwide suffer from hidden hunger caused by deficiencies in essential micronutrients, particularly zinc (Zn). Conventionally, Zn deficiency in humans has been addressed through di...
Co-modulation of clinical courses of hypertension and depression in public health facilities in Ethiopia: A six-month follow-up study protocol
Background The co-occurrence of hypertension and depression is increasing both in magnitude and complexity, negatively impacting treatment outcomes of both conditions. Given that b...
Based on single-cell and transcriptome analysis of inflammatory pathway biomarkers and their molecular mechanisms in chronic obstructive pulmonary disease
Background Systemic inflammation in chronic obstructive pulmonary disease (COPD) presents significant therapeutic challenges. Our study employs integrated transcriptomic and single...
Democracy, transparency, economic development, religion, and women on boards of national Olympic committees: Evidence from 89 countries
The authors investigate the connection between a country’s level of democracy, transparency, economic development, religion, and the representation of women on the national Olympic committees’ (NOC) b...
The associations of dietary exposure to selected food additives with dietary patterns and overweight
Background The global rise in obesity correlates with increased consumption of ultra-processed foods, which often contain various food additives. The impact of these additives on o...
A novel mRNA-based multiepitope vaccine candidate against Cryptosporidium hominis and Cryptosporidium parvum employing reverse-vaccinology and immunoinformatics approaches
Introduction The parasite Cryptosporidium spp. causes cryptosporidiosis, a diarrheal disease in humans and animal...
Multi-site bone marrow core biopsy improves diagnostic accuracy in dogs with hematologic disease
Background Spatial heterogeneity within bone marrow significantly affects diagnostic accuracy in human and veterinary medicine, where single-site sampling may fail to detect focal...
Physiology-driven reversible dynamic synthetic tissue model for responsive moulage in infected wound training
Misidentification of dermatologic manifestations of systemic infection can lead to life-threatening developments including sepsis. Training medical providers to accurately identify and respond to infe...
Is preoperative emergency department utilization associated with postoperative healthcare utilization after total joint arthroplasty? A social vulnerability index based analysis
Background As the need for total joint replacement increases with an aging population, there is increased attention to perioperative healthcare utilization. Efforts to mitigate com...
Penalty kick or not? Differences in the interpretation of handball incidents in professional association football
Handball decisions in the penalty area remain one of the most controversial topics in professional association football, yet they are underexplored in sports science. The purpose of this research was...
Distinct DNA methylation signatures in maternal blood reveal unique immune cell shifts in preeclampsia and the pregnancy-postpartum transition
Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by immune dysregulation and significant risks to maternal and fetal health. While current management relies on high-risk patient...
Research on the influence mechanism of structural separation on the damage excitation of bridge piers under seismic motion
This study builds a special numerical model based on the OpenSees platform, aiming to explore the influence of structural separation on the damage of bridge piers under excitation. The key parameters...
Enhancing gait training with anti-gravity treadmill ‘Alter-G’ in patients with Parkinson’s disease
Background Freezing of Gait (FoG) is a debilitating motor symptom affecting nearly half of individuals with Parkinson’s disease (PD), increasing fall risk and reducing independence...
Mapping the evidence on outcomes of childhood out-of-home care: A scoping review of reviews
Background Children placed in out-of-home care in high-income countries face complex challenges due to exposure to adverse childhood experiences and systemic disadvantages. While r...
Protocol for testing global neuronal workspace and integrated information theories of consciousness in non-human primates and mice
Identifying the neural correlates of consciousness (NCC) is widely regarded as imperative to our understanding of consciousness. Although several scientific theories of consciousness make predictions...
Intervening and reducing sharing of false cancer treatments on social media: Online experiment
Background Cancer treatment misinformation (e.g., false cures) is shared widely on social media and harmful. Cancer treatment misinformation is potentially shared because people wa...
Unequal by the gun: Four decades of the Black-White firearm homicide gap
Background: Firearm homicide is a leading cause of death in the United States, with substantial racial disparities documented over time. Black Americans experience disproportionate...
ANCHOLIK-NER: A benchmark dataset for Bangla regional named entity recognition
Named Entity Recognition (NER) in regional dialects is a critical yet underexplored area in Natural Language Processing (NLP), especially for low-resource languages like Bangla. While NER systems for...
Synergistic effects of physical-mental mixed fatigue on badminton forehand smash performance
Purpose Badminton’s forehand jump smash is critical for offensive success, yet its performance often declines under fatigue. Previous studies have separately examined physical or m...